Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

RFK Jr critic Paul Offit removed from FDA vaccine advisory committee. Paul remains one of the most thoughtful scientists I know to articulate the importance of vaccine safety and proper clinical trials!

In @elife.bsky.social: IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion doi.org/10.7554/eLif...

Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

It's #MucosalMonday! Catch the latest Mucosal Immunology podcast, "Timing Exposure to Microbes," featuring Dr. Michael Silverman, from Children's Hospital of Philadelphia - brought to you by SMI and the Mucosal Immunology Journal. Listen here -> bit.ly/4lxNC7F

#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production! www.nature.com/articles/s41...

Yes plague still exists in many parts of the world including the western US: What to Know About Plague After a New Case in California www.nytimes.com/2025/08/22/h...

"If Joe Biden federalizes the National Guard, that would be a direct attack on states' rights." - Kristi Noem, Feb 6, 2024

We’re pleased to share our new study, led by @jezieldamasceno.bsky.social, that used long-read, single molecule sequencing to reveal the full (?) picture of Leishmania DNA replication. Thanks, Mike Boemo and helpful reviewers @uofgsii.bsky.social www.sciencedirect.com/science/arti...

Experts condemn NIH director’s defense of cut to vaccine research

Expanding the cytokine receptor alphabet reprograms T cells into diverse states @natmicrobiol.nature.com #GarciaLab @xrtcell.bsky.social www.nature.com/articles/s41...

Looks like one of our ‘imprinting’ papers was cited in the HHS data package, despite our conclusion that people receiving an ancestral mRNA vaccine were better at producing antibodies against variants compared to unvaccinated people.

This has a ice response to a lack of critical thinking www.statnews.com/2025/08/11/m... via @statnews.com

Co-authors when you ask them to go over a draft in August

For those with an interest in enteric infections (or if you have had Beaver Fever): this commentary summarizes recent studies on the potential benefits of Giardia. Public offering of shares in ParasitesAreUs to come.... rdcu.be/ew8nk

Messenger RNA vaccines aren’t just saving human lives—they are protecting elephants as well. Juvenile elephants Sanjay and Kabir at the Cincinnati Zoo received the first messenger RNA vaccine designed to protect elephants from a deadly virus. cen.acs.org/pharmaceutic... 🧪

Trump team axes contracts with publishing giant Springer Nature At first, NIH told me its contracts with SN were active and that they help “advance scientific discovery”. Hours later, HHS said the opposite: "Precious taxpayer dollars should not be used on unused subscriptions to junk science.”

Improving T-cell responses to vaccines ft. @emilyaunins.bsky.social (@cambupenn.bsky.social), @kingofpathogens.bsky.social, A. Phan (@PennVet), S. Domchek (@PennCancer), @drewweissmanlab.bsky.social (Penn Med) @MgAlameh (@PennPathLabMed) & @scottehensley.bsky.social (@PennMicro) tinyurl.com/2p8xztbz

Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!

New in #Science #Immunology: Researchers at Sun Yat-Sen University in Guangzhou report that #BloodCancers expressing PSGL-1 can prevent the #integrin signaling #macrophages need for #phagocytosis. Targeting PSGL-1 improved survival in mouse models of #leukemia, #lymphoma, & #MultipleMyeloma!

Last week was big for IL-12 engineering @cytokinesociety.bsky.social : Membrane-IL12 adjuvant mRNA vaccine polarizes pre-effector T cells for optimized tumor control url:https://rupress.org/jem/article-abstract/222/9/e20241454/278038/Membrane-IL12-adjuvant-mRNA-vaccine-polarizes-pre

Ha - big week for IL-12... De-coupling immune parameters and toxicity associated with IL-12 agonism: Cell Reports www.cell.com/cell-reports...

De-coupling immune parameters and toxicity associated with IL-12 agonism @cp-cellreports.bsky.social @kingofpathogens.bsky.social www.cell.com/cell-reports...

#WeekendRead! #BeyondPatternRecognitionReceptor! Witt, Russel Vance &co show @nature.com that SP140 at the same time inhibits DNA viruses but also represses RESIST destabilizing interferon-b RNA, linking antiviral effector triggered immunity to multiple sclerosis & B cell tumors!

"Two of HHS Secretary Robert F. Kennedy Jr.’s new appointees to the CDC’s vaccine advisory board have previously served as paid expert witnesses for plaintiffs suing Merck over its HPV and MMR shots." endpoints.news/two-new-acip...

Bluesky Microbial Path community - this ones for you. Time to break out those high risk high reward projects..... Its just a one pager to get going. www.bwfund.org/funding-oppo...

IFN-γ–resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models | Science Translational Medicine @cytokinesociety.bsky.social www.science.org/doi/10.1126/...

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

NIH staff and biomedical community sound alarm about agency politicization, funding slowdown | Science | AAAS www.science.org/content/arti...

We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below: www.science.org/doi/10.1126/... @cytokinesociety.bsky.social

🌟 Calling all women leaders in immunology! The EJI Ita Askonas Prize 2025 offers €20,000 + ECI 2027 travel to outstanding female group leaders who have run an independent lab. Apply or nominate a colleague via BSI by 20 June! Find out how to apply: https://bit.ly/4kzbwzu

The astounding contribution of US academic science to new medicines www.statnews.com/2025/06/06/u...

Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source | Science Immunology www.science.org/doi/10.1126/...

How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social www.science.org/doi/10.1126/...

mRNAs encoding adjuvant proteins boost immunity. A fantastic study from Hunter et al shows the value of IL12. Study validates original work on this concept, ref below. Kudos to the authors on this exciting discovery! www.science.org/doi/10.1126/...

An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses @sciimmunology.bsky.social @kingofpathogens.bsky.social www.science.org/doi/10.1126/...

Happy to be part of @kingofpathogens.bsky.social study showing mRNAs encoding IL-12 enhance CD8 T cell responses to co-administered HA mRNA vaccines. Study led by Emily Aunins and Anthony Phan from the Hunter lab @upenn.edu www.science.org/doi/10.1126/...

The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost! New content every week! Check it out! www.science.org/toc/sciimmun...

In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)? In collaboration with @herassr.bsky.social and @heick.bsky.social labs www.biorxiv.org/content/10.1...

I mean I knew American universities were an expensive business, but…

This week in #Science #Immunology: Boisson-Dupuis, @casanovalab.bsky.social, & colleagues identify in 3 unrelated individuals w/ #tuberculosis a rare autosomal recessive complete deficiency in #LY9 linked to impaired #IFNg production by CCR4−CCR6+CXCR3+T-bet+RORγT+ TH1* cells (aka TH1/17 cells)!

The Last of Us may be over for now, but fungus pandemic news endures. Here's my story on how white-nose disease, which has battered North American bats, may have more devastation in store. 🧪 Gift link: nyti.ms/4mGRyV8

Chris Hunter @kingofpathogens.bsky.social and colleagues review parasite and host immune factors that impact the development of a mucosal vaccine for #Cryptosporidium : www.mucosalimmunology.org/article/S193...

ICYMI, a short 🧵

In the latest #Science #Immunology: researchers @ Tsinghua U report that #ILC3 augment group #ILC2 #anthelmintic immune responses in 🐁! Upon N. braziliensis infection, ILC3-derived #RANKL synergizes w/ #IL13 to facilitate intestinal #TuftCell expansion, which amplifies ILC2 responses!

More than half of the National Science Foundation grants terminated since April fund programs that would help students train in science, engineering and math. Story by @katrinamillerphd.bsky.social Gift link: nyti.ms/3Shu4rt