Sign up now for the EMBO Workshop "#MolecularBiology of #Archaea: Life Through the Prism of Archaea" in Cambridge, UK, 6–10 July 2026. Deadline: 15 April https://meetings.embo.org/event/26-archaea#MolecularBiology#Archaea#EMBOArchaeaBiology #EMBOevents #CellBiology #StructuralBiology #ecology #evolution #biophysics 🧪

We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance. tiny.cc/vilw001 #PhD #CancerResearch #GenomeStability #Chromatin

Born #OnThisDay in 1922, Esther Lederberg was the first to isolate the lambda phage in 1951. She characterised the lysogenic phase, whereby the phage are able to integrate into the bacterial genome, staying dormant. This discovery made them a model tool of study, leading to many more breakthroughs.

💥 alert article 💥 New preprint from the lab !!! 🥳 In this work, we explore the 3D genome architecture of the virulent phage PAK_P3 during its infection cycle in P. Aeruginosa. We unveil a highly dynamic structuration as well as specific interactions patterns. www.biorxiv.org/content/bior...

Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious? Either way, we have good news. We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July. Sign up: meetings.embo.org/event/26-arc... We look forward to seeing you in Cambridge, UK Please repost!!

Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts. www.biorxiv.org/content/10.6...

Delighted to share our new preprint: www.biorxiv.org/content/10.6... We address a longstanding question about the role of the topoisomerase reverse gyrase in hyperthermophiles. Great collaboration with Baranello and @tobiaswarnecke.bsky.social groups. #Archaeasky #Microsky

Treat yourself this Christmas to a registration for the #Shigella2026 meeting in Paris!

Must read!

DAY 182 SPECIES 182 - Pyrolobus fumarii STAGE: Archaea MEDIUM: Arches Paper. Chromatek & HWC Watercolor. Tombow pencil. Sakura pen P. fumarii is a species of archaea known for living and reproducing at extremely high temperatures that kill most organisms. #sciart #watercolor #archaea #art #paint

Our study of the evolution of the ParB NTP binding domain across the Tree of Life is now published! An awesome collaboration with @tunglejic.bsky.social led by @jovanakaljevic.bsky.social at the John Ines Center. Thanks to editors and reviewers. www.pnas.org/doi/10.1073/...

Everybody ready for #EMBOevoChromo25 ? I, for one, cannot wait. It's like scientific Christmas come early :)

gene names are great but really making sure a unique ID (genbank or consort) is mentioned somewhere in a paper is essential, future us will be thankful

So much fun! Catch up at 9pm tonight or on BBC Sounds at your leisure www.bbc.co.uk/programmes/m...

✨ A study in nature.com from our Faculty at @unikarlova.cuni.cz reveals Solarion arienae, a rare #protist forming a newly identified eukaryotic supersroup Disparia. A unique window into early #eukaryotic cell #evolution. 🌍🔬👏 www.nature.com/articles/s41...

Chromosome segregation in the highly polyploid archeon Haloferax volcanii was long thought to be random. Turns out a ParA family protein coupled with a non parB protein does the job. Is that one of the few examples of active segregaton of multi copy identical replicons?

Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1

1/6 PhD /PostDoc positions available. Exploration of physiological functions of the cell fusogen Fusexin1 in Archaea. In a collaborative project between the Albers lab (Freiburg) and the Podbilewicz lab (Technion) starting in January 2026.

Did someone say Asgard? www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

At this rate of (amazing) papers/preprint, Asgard archaea will have an opposable thumb within next month 😂

Excited to share our new preprint on BioRxiv! A collaborative effort spanning many years and several labs to uncover what the germline chromosomes of Paramecium really look like. 🔗 www.biorxiv.org/content/10.1... 1/5

End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon. 🌐 evedesign.bio

Now published: EnVhogDB, a large database of viral protein family HMM profiles to help functional annotation of new phage genomes - peercommunityjournal.org/articles/10....

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...

« A key event in any cell’s life is division, when one cell becomes two » best opening, congrats to the team!

Our paper on chromosome segregation in the archaeon Sulfolobus Acidocaldarius has been published in PNAS! This has been a great collaboration with @joeparham19.bsky.social and the rest of @buzzbaum.bsky.social's team. Stay tuned for more to come!😉 @istaresearch.bsky.social doi.org/10.1073/pnas...

Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out: www.nature.com/articles/s41... Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social

I'm preparing a lecture on prokaryotic chromosomes, which will include some discussion on ploidy. I was curious to know if some of the ASGARD archaea are polyploid so I googled it. This is Gemini's results 😅😅😑

I hope that genophore will one day make a come back instead of nucleoid for prokaryotic chromosomes

Thrilled to see this work in its preprint form! A great collaboration with Jovana and Tung to explore the evolution and properties of the surprisingly versatile nucleotide binding domain of ParB.

Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!

SEPTEMBER's EDITOR's CHOICE: Intergenic, repetitive motifs that act as nucleosome repleted regions in the budding yeast genome, have evolved de novo into novel protein-coding genes: doi.org/10.1093/jeb/... @vakirlis.bsky.social @timothyfuqua.bsky.social

The lab github is here: github.com/mol-evol/ so you can get an idea of what we have been working on recently (several projects are private at the moment, so this will be bigger soon) and the job ad is here: www.jobs.ac.uk/job/DOU184/p...

📝New preprint! #MicroSky 🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy. 🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation. www.biorxiv.org/content/10.1...

Only single cell sequencing of the all these post docs will reveal why

You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range. @rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social www.nature.com/articles/s41...

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

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Please re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September

Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...

Feeling mitochondrially challenged lately? Here are two classic reviews on #mitochondria that should help. www.cell.com/current-biol... www.cell.com/current-biol...

Good, and about time too. A shameful example of eugenics in recent European history. Denmark issues first apology over forced contraception of Greenlandic women www.theguardian.com/world/2025/a...

Third Era of Phylogenetics! 1️⃣ Era 1: Morphology 🦴 2️⃣ Era 2: Sequences 🧬 3️⃣ Era 3: 3D Structures ⚛️ Solving deep evolutionary puzzles like never before. Our new review in GBE explores what's next in #phylogenetics academic.oup.com/gbe/article/... #structuralbiology #evolution #AlphaFold #SciSky

This first-author publication is my… first! Archaea kill bacteria by targeting their Achilles’ heel: peptidoglycan. Big shoutout to @ahocher.bsky.social‬, @valeriesoo.bsky.social‬, Pauline Misson, @tobiaswarnecke.bsky.social‬ and MRC LMS Proteomics. A thread 🔽 journals.plos.org/plosbiology/...

@romainstrock.bsky.social work is out! Why should you care? Because it helps shift our view of archaea — from rare extremophiles to not-so-passive bystanders. Some archaea can also fend off bacteria. Glad to be part of this cool project from @tobiaswarnecke.bsky.social. Opens lots of Questions.

Archaea are often surrounded by bacteria. But is there ever active conflict between the two? Can archaea kill bacteria? If so, how do they do it? Work by @romainstrock.bsky.social shows that some archaea can kill bacteria by secreting peptidoglycan hydrolases. journals.plos.org/plosbiology/...

Happy to share our new paper out today in @cp-cellreports.bsky.social in collaboration with @tobiaswarnecke.bsky.social @akihisaosakabe.bsky.social about how evolution can do big things with small changes. www.sciencedirect.com/science/arti...

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

Excited to share our latest work with @jamesbriscoe.bsky.social . A global #cis-regulatory temporal program guides how spatial cues are interpreted in neural progenitors. We show how #space and #time can be integrated to generate cell type diversity in the #spinalcord. Congrats to all authors.

Can genetics grow a better garden? 🌻🪴 In this Naked Scientists episode, @aylwyn-scally.bsky.social digs into the roots of genetics and how it could help gardens face climate threats like drought and pests. www.thenakedscientists.com/podcasts/naked-scientists-podcast/can-genetics-grow-better-garden