Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!

Day 24 of making proteins for #ArtAdventCalendar The nuclear pore complex is a huge pore made of hundreds of proteins, that allows the flow of nucleic acids and proteins between the nucleus and cytoplasm. It also looks like a wreath! Merry Christmas! More projects: e-nox.net/portfolio/ #SciArt

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

My "News & views" was published today @natmethods.nature.com Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left... www.nature.com/articles/s41...

I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...

How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work! www.nature.com/articles/s41... www.nature.com/articles/s41...

Day 6 of making proteins for #ArtAdventCalendar This is a "nanodisc", which is a tiny section of lipid membrane, just big enough to hold a single membrane-bound protein, and holds the structure stable enough to probe its structure More projects: e-nox.net/portfolio/ #SciArt

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II: www.biorxiv.org/content/10.6...

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments? Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation doi.org/10.64898/202...

The EMBO Gold Medal 2025 was awarded to Tanmay Bharat and David Bikard: https://www.embo.org/press-releases/embo-gold-medal-2025-awarded-to-tanmay-bharat-and-david-bikard/ 🧪 At #CellBio2025, the EMBO Gold Medal was handed over to David Bikard in recognition of his pioneering work on #GeneEditing.

Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science. The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7

Day 5 of making proteins for #ArtAdventCalendar Today it's HLA-A2, which is critical for the immune system. They present fragments of intra-cellular proteins to CD8+ T cells, which can initiate a targeted immune response. More projects: e-nox.net/portfolio/ #SciArt

BBC News - Top UK scientist says research visa restrictions endanger economy www.bbc.com/news/article...

Check out the latest paper from Leo James and William McEwan which explains the science behind LMB spin out TRIMTECH Therapeutic's TRIMTAC® degraders ⤵️

🧬 CRN Team De Camilli found that BLTP3A/UHRF1BP1 binds VAMP7 vesicles to lysosomes and activates the CASM pathway after lysosome damage. This drives mATG8 recruitment and helps restore lysosome integrity. 🔗 Check out the full #publication to read more about their findings: bit.ly/4o27nF0

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

Happy to share our newest preprint on antigen presentation of Mtb-derived peptides on MHC-I: www.biorxiv.org/cgi/content/... This is a follow up to our previous paper where we applied immunopeptidomics to understand MHC-I presentation by Mtb-infected cells: elifesciences.org/articles/84070

GPR34 is a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells @jem.org rupress.org/jem/article/...

An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense. @cedarssinai.bsky.social rdcu.be/eNIFY

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

Delighted that our latest paper is out @jem.org. An intriguing study led by Ana Cardoso exploring the role of DNGR-1 in mouse dendritic cell precursors.

Looking forward to meeting PFP enthusiasts at the Prato conference on Pore Forming Proteins in June! ⏰ Early Bird Registration deadline - May 16th ⏰ www.pratopores.org/speakers #PFPsky

At last, direct demonstration that tapasin dependent MHC-I molecules experience greater tapasin filtering, resulting in less diverse MHC-I immunopeptidomes that are enriched in high affinity peptide-MHC-I complexes. Well done Andy and Rachel! links.email.frontiersin.org/ls/click?upn...

Wow! Amazing response in the first few days of registration opening for www.emds2025.com Be sure to register early to avoid disappointment. 🚨 Abstract deadline is FRIDAY 30th MAY (Sneak peak of @profandrewmac.bsky.social rehearsing for the 'Scotland Experience' social.)

👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social www.cell.com/immunity/abs...

Thank you to organisers Philippe Bousso, Gillian Griffiths @griffithslab.bsky.social , Milka Sarris & Michael Sixt, and everyone who joined us for our 'Immune Cell Interactions in Development, Homeostasis and Immunity' Workshop. biologists.com/workshops

Our work on K63-polyubiquitin in membrane trafficking is out! Check out how we use a high affinity and specific sensor for K63-polyUb to identify K63-polyubiquitylated plasma membrane proteins in clusters of vesicles containing ATG9A. Link: www.molbiolcell.org/doi/10.1091/...

How to explain cross-presentation in a pub? #DendriticCells #APCsky #MHCsky

The LMB Rising Talent Fellowship for Black heritage scientists is open for applicants! With this 3 year postdoc position we want to enable scientists of Black heritage to learn & grow their experience. To apply and for full details check here: www2.mrc-lmb.cam.ac.uk/recruitment/...  Please share!

Our latest ‘Cell Scientist to Watch’ interview is with Kelly Nguyen @kellythd-nguyen.bsky.social @mrclmb.bsky.social. We learn about Kelly’s career, her advice on collaborative research and her passion for martial arts. journals.biologists.com/jcs/article/...

It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find! www.nature.com/articles/s41...

Interested in cellular cross-talks between dendritic cells and T lymphocytes in lung cancer? Our team is recruiting a postdoctoral associate in immunology at Institut Pasteur Paris! research.pasteur.fr/fr/job/post-...

Melero&Co discuss the crucial role of conventional type 1 dendritic cells in cross-presenting antigens to prime CD8+ T cells to mount anti-tumour immunity and highlight how this can be exploited for #CancerImmunotherapy @unav.edu#CancerImmunotherapy 📖 ⬇️

There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested: #immunosky #virology 🧪 www.jobs.cam.ac.uk/job/50254/

WDFY4-dependent cross-presentation of immune complexes by cDC1 and cDC2 @jem.org doi.org/10.1084/jem....

Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology! You will be supported by core funding, excellent facilities & enthusiastic colleagues. Apply by 18 MAR www.nature.com/naturecareer...

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky

📆ny resolution #immunosky: REGISTER NOW #phagocytes25 phagocytes2025.com 20 🔝speakers 28 short talks + posters 📌Madrid @CNIC_CARDIO 📆26-28 March '25 Organized by www.inmunologia.org Support by #TRR332 #TRR359 #inmunotek #EMBOevents Bursaries by @efis-immunology.bsky.social @eurjimmunol.bsky.social

A cellular Christmas tree made from molten copper drops. Splats of copper sometimes happen when welding and they often take the shape of different cell types. I collect these off my shop floor because they look cool…….and yes, they make my sciency senses tingle! Merry Christmas! #SciArt

MERRY CHRISTMAS!!! I'm not sure if this is how the gold, frankincense and myrrh were delivered, but perforin-2 is excellent at transporting gifts... Made in #Modo for @patrycja-kozik.bsky.social Lab #ArtAdventCalendar #SciArt More projects: e-nox.net/portfolio/

Just a little reminder on the important role of perforin-2 in transport... 🎁🎁🎁 🎄 Happy Christmas everyone! 🎄 Image credits: @e-nox.net #KozikLabScience #PFPsky

Calling all those talented researchers of black heritage! 📢📣🤩 Seek which research programmes call to you across the @mrclmb.bsky.social divisions, get in touch & keep an eye open for when the application process opens in Jan/Feb 2025! www2.mrc-lmb.cam.ac.uk/recruitment/...

News from the lab: we went skating and we all survived! Thank you to @immunoah.bsky.social for organising a joint Christmas lunch 🎄 #KozikLabMembers #KozikLabUpdates

It is great to see a lot of familiar faces at #UKMT2024 in London! A big thank you to Chris Stefan and @jezcarlton.bsky.social for organising and putting together an exciting programme for the day. #KozikLabUpdates

Ok, I made a starter pack for membrane trafficking and organelles (broadly defined). Feel free to self-nominate! go.bsky.app/RbtJjt7

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪 go.bsky.app/PY5tCas go.bsky.app/FmERUoD go.bsky.app/6aT6qDS go.bsky.app/QSEPDoj

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4