@jeffreybode.bsky.social
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It's finally out – actually out and in print! Many thanks to
@jcornlab.bsky.social
@matthiasmuhar.bsky.social
@jakobfarnung.bsky.social
and all the fantastic collaborators. What started as pure curiosity lead to an amazing find!
www.nature.com/articles/s41...
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C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
https://www.nature.com/articles/s41586-024-08475-w
9 months ago
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reposted by
Micha Rapé Lab
10 months ago
Very excited to highlight @jcornlab's beautiful work on the E3 ligase SCF-FBXO31, which recognizes chemically damaged proteins. Mutations in FBXO31 cause disease by substrate-rewiring, really cool. Congratulations to all authors!
rdcu.be/d7WGc
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Signs of damage that drive protein degradation | Nature
Many environmental toxins damage proteins, which then must be removed to avoid dangerous protein aggregation and disease. How cells dispose of chemically modified proteins has been unclear, but a discovery offers some clues. How the stress-response machinery eliminates damaged proteins.
https://rdcu.be/d7WGc
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reposted by
Clausen Lab
10 months ago
scary but fascinating - cells have a degradation pathway that hunts down C-terminal scars (amides!) on damaged proteins. just wow. chemical biology plus CRISPR at its best. big congrats to all authors!
www.nature.com/articles/s41...
loading . . .
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
https://www.nature.com/articles/s41586-024-08475-w
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