[PUBLICATION] The @membramics-lab.bsky.social shows how Influenza A virus rewires ER lipid metabolism to promote vRNP egress. 👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social journals.plos.org/plosbiology/... w/ @institutpasteur.bsky.social & IPNP @plosbiology.org

[PUBLICATION] NEW in @cp-cellreports.bsky.social @julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation. 📖 www.cell.com/cell-reports... @membramics-lab.bsky.social

👏🏼 Proud to see @julianedagraca.bsky.social, former PhD student at INEM, honored with the 2025 Beth Levine Thesis Prize for her outstanding work on autophagy, supervised by Etienne Morel @membramics-lab.bsky.social.

[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA. 📨 Apply by Sept 1. 🟢 Start Nov–Dec 2025. www.institut-necker-enfants-malades.fr/offre-demplo...

🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links. 🗓 Apply by Sept 20, 2025 🔗 More info: institut-necker-enfants-malades.fr/careers

[PUBLICATION] New study with the Bharat lab @cellbiol-mrclmb.bsky.social reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. 🦠 Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis. @mathieucoureuil.bsky.social @pnas.org www.pnas.org/doi/10.1073/...

[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key. | Canaud Lab @pnas.org 🔗https://www.pnas.org/doi/10.1073/pnas.2424867122

[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙 A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org 👉 www.science.org/doi/10.1126/...

🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at @iocbprague.bsky.social. Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social

[PUBLICATION] mTORC1 coordinates ependymal cell differentiation by regulating an alternative cell cycle and centrosomal proteins. A new collaboration between the Pende and Spassky labs! 🔗 www.embopress.org/doi/full/10.... @mario-pende.bsky.social @ibensens.bsky.social ‪@emboreports.org

[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum. ➡️Fertility preserved ➡️No embryotoxicity ➡️Disease remained responsive after treatment pause 📖 Read more: www.nature.com/articles/s41... @ejhg-journal.bsky.social‬

🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!

🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at @pasteur.fr. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! @mario-pende.bsky.social

✨ Calling all postdocs! The 2025-2026 #ParisPostdocs Seminars are now accepting applications. Present your work, connect across 13 top Paris institutes — including INEM — and boost your visibility 🚀.

🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at LIMES Institute @unibonn.bsky.social. ‬ Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it! @venteclefn.bsky.social

Join #ParisPostdocsSeminar this month to hear from our very own Laura Salavessa (@laurasalavessa.bsky.social) as she shares new insights on melanin transfer and uptake in keratinocytes. 📅 Tuesday, 27 May 🕚 11:00–12:00 CET 📍 Institut Pasteur – Amphitheatre Agnès Ullmann

🚨 We're hiring! The IMMEDIAB team is looking for: 🧪 1 Postdoc 🧬 1 Research Assistant / Bioinfo/ Tech 📍 Paris | Start Sept 2025 📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers @drfalzaid.bsky.social

[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement. A promising step toward targeted therapy in PIK3R1-related disorders. 📄Read more: www.embopress.org/doi/full/10.... Canaud Lab @emboreports.org

🗓️ Join us on Friday, May 16, for a #seminar with Chantal Desdouets, Head of the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at @crcordeliers.bsky.social. Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social

🗓️ Join us for a special #seminar with Bing Su, Director of the Shanghai Institute of Immunology & Chair at Shanghai JiaoTong Univ. School of Medicine. Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social

🗓️ Join us on Monday, Apr 28, for a #seminar with Christopher Goodnow, Head of the Immunogenomics Lab at @garvaninstitute.bsky.social. Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social

🎉 Congrats to Khaled Tighanimine, former PhD student at INEM (supervised by @mario-pende.bsky.social & Stefano Fumagalli), awarded a @fondationarc.bsky.social Oberling-Haguenau Thesis Prize! Proud to see his work recognised among this year’s #ARCTrophies winners 👏

🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health. He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social

🚨 Postdoc Opportunity Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis. 🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo... @mathieucoureuil.bsky.social

🗓️ Join us on Friday, April 11, for a #seminar with Prof. Philippe Sansonetti @pasteur.fr on Gut dysbiosis and colorectal cancer. Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.

🏆 Congrats to @julianedagraca.bsky.social! Former PhD student at INEM, Juliane has been awarded the 2025 Thesis Prize of the @clubexo-endo.bsky.social for her work on ER-endosome contact sites & autophagy regulation. 👏 Well done, Juliane! @membramics-lab.bsky.social

🗓️ Join us on Friday, April 4, for a #seminar with Dr. Meryem Baghdadi, new team leader at INEM (StemNest Lab), on "Stem cell regulation in homeostasis and disease." Don't miss this talk exploring how stem cells maintain tissue balance — and what happens when this goes wrong!

🚨 New: Spleen-resident macrophages (MMMs) can directly activate CD8+ T cells to fight tumors – independently of dendritic cells. They use a vacuolar MHC-I pathway & need Batf3 for this antitumor response. 🧠 A game-changer for immunotherapy? 🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social

🗓️ Join us on Friday, March 28, for a #seminar with Dr. @goetzjacky.bsky.social (Centre de recherche en biomédecine de Strasbourg) on "Multi-modal tracking of metastasis: from priming to inhibitory targets." 🔍 A great chance to dive into new insights on cancer metastasis. @membramics-lab.bsky.social

🗓️ Join us on Friday, March 21, for a #seminar with Dr. Olivier Tabary on "ANO1: A new approach for cystic fibrosis — from basic science to translational studies." Don't miss this opportunity to learn more about new therapeutic avenues in #CysticFibrosis research!

📖 [NEW] PI3K-driven leukemias exploit glutamine metabolism for survival. @guillaumeandrieu.bsky.social et al. show that mTOR inhibition + glutamine degradation induces potent cytotoxicity— a novel strategy to target metabolic adaptation in PI3K-driven cancers. 🔗 nature.com/articles/s41...

🦠 Shigella flexneri exploits a human-specific miRNA to spread! New study shows that miR-6762-5p activates RhoA GTPase, enhancing cytoskeleton remodeling & boosting bacterial dissemination. Host-pathogen interplay at the molecular level! 📖 Read more: onlinelibrary.wiley.com/doi/full/10....

🗓️ Join us on Friday, March 14, for a #seminar with Prof. Aurélien Roux (Biochemistry Dept, University of Geneva) on ESCRT-III membrane remodelling insights from Asgard archaea. Don't miss this opportunity to learn more about membrane dynamics! @membramics-lab.bsky.social

🗓️ Join us on Friday, March 3, for a #seminar with Prof. Peter Sebo (Institute of Microbiology, @czechacademy.bsky.social) on the resurgence of whooping cough and how it works. Don't miss this opportunity to learn more about this pressing issue!

🧠 How do blood-borne factors support cognitive resilience? New study in @natureaging.bsky.social reveals a primary cilium–autophagy axis in hippocampal neurons, mediating the effects of osteocalcin on neuronal plasticity & aging. 🔗 Read here: www.nature.com/articles/s43...

🧫 New #Review - Porin modifications shape carbapenem resistance, fitness & virulence in Enterobacteriaceae & P. aeruginosa. How do bacteria adapt under antibiotic pressure? Find out in @plos.org Pathogens. 📑Read here: journals.plos.org/plospathogen...

🎓 PhD Positions in mTOR Signaling & Disease We’re recruiting 2 PhD candidates as part of the @mentor-program.bsky.social coordinated by @mario-pende.bsky.social. 🔗 Details & application here: www.institut-necker-enfants-malades.fr/index.php/en...

📢 Paris Postdocs Seminars at INEM On Feb 27, we are hosting Huiqiong Wu (@ijmonod.bsky.social) for a talk on "The regulation of epithelial tissue homeostasis by active trans-epithelial transport", as part of the #ParisPostdocsSeminars series! Join us!

➡️ Great to see INEM's Nathaniel Hennman presenting at the Paris Postdocs Seminar! Don’t miss his talk on nuclear functions of nutrient sensing for metabolic adaptation at Institut Jacques Monod on Feb 25. #ParisPostdocSeminar

🔬 [RECRUTEMENT] L’équipe Épigénétique et Développement @marco-pontoglio.bsky.social cherche un⸱e ingénieur⸱e d’étude pour un projet visant à identifier de nouvelles cibles thérapeutiques dans les maladies rénales. 📩Pour postuler : www.institut-necker-enfants-malades.fr/offre-demplo...

🗓️ Join us on Friday, Feb 14, for a #seminar with Jean-Philippe Herbeuval, Research Director @cnrs.bsky.social and CBMIT Group leader. Dr. Herbeuval will discuss how CXCR4 minor pocket agonists (MiPAs) regulate type I interferon, from HIV transmission to new therapies. @fabiolaterzi.bsky.social

📖 "La fatalité de la mucoviscidose sera-t-elle vaincue ?", a new book, by Aleksander Edelman, Isabelle Sermet and Georges Travert, explores the history of cystic fibrosis and the breakthroughs that have transformed the management of this genetic disease. www.editions-harmattan.fr/catalogue/li...

🚨 Postdoc opportunity in kidney disease research! The @fabiolaterzi.bsky.social Lab is hiring a postdoctoral fellow to study CKD progression using mouse models, CRISPRi/a & molecular biosensors. 📩Apply now: www.institut-necker-enfants-malades.fr/index.php/of...

📢PhD opportunity! The @mentor-program.bsky.social coordinated by @mario-pende.bsky.social is recruiting PhD candidates to explore mTOR signaling in health & disease. Join this MSCA-DN program at the forefront of metabolism & rare diseases research! @upcite.bsky.social 🔗Apply now: mentor-program.eu

🗓️ Join us on Friday, Feb 7, for a #seminar with Prof. Laurence Zitvogel, immunologist, oncologist and leader of the "Tumour immunology and immunotherapy" group at Institut Gustave Roussy 🔬 Prof. Zitvogel will unveil the secrets of cancer immunotherapy. Don’t miss it!

🗓️ Join us on Friday, Jan 31, for a #seminar with Philippe Pierre, leader of the "Dendritic Cell Biology" team and former Director of @ciml.bsky.social. Dr. Pierre will discuss the functional consequences of endo-lysosomes mispositioning in phagocytes.🔬Don’t miss it! @fabiolaterzi.bsky.social

📃 New preprint! Keratin filaments position melanin pigments to shield DNA from UV damage. A collaboration between @inem-necker.bsky.social @institutcurie.bsky.social & L'Oréal. Cedric Delevoye, Laura Salavessa, @membramics-lab.bsky.social Read here: www.biorxiv.org/content/10.1...

🗓️ Join us on Friday, Jan 24, for a #seminar with Wilbert Zwart @zwartlab.bsky.social, Professor of Functional Genomics in Oncology at TU Eindhoven and Group leader at The Netherlands Cancer Institute. Prof. Zwart will explore Hormones, Epigenetics and Cancer. 🧬Don’t miss it! @goffinlab.bsky.social

Welcome to the official Bluesky account of Institut Necker Enfants Malades (INEM)! 🧬✨ We’re dedicated to advancing research in molecular & cellular metabolism, immunology, and beyond. 🦋 Follow us for updates on our discoveries, events, and collaborations. #Science #Research #HealthInnovation