Happy to share our study published in @bloodjournal.bsky.social 🧬✂️🛑 We report that intragenic deletions of LEF1 generate a dominant-negative isoform and confer a targetable dependence on the Wnt/β-catenin pathway in T-ALL Full story 👉: doi.org/10.1182/bloo...

A fantastic program, insightful discussions, and exciting perspectives coming from the @helloeacr.bsky.social EACR Conference ‘Persister Cells’ on how to better identify, characterize and target drug-tolerant persister cells to leverage the treatment of bacterial infections and cancers.

📣Thrilled to share our recent study presenting a clinical-grade targeted therapy to exploit a metabolic vulnerability of PI3K-driven leukemia published in @naturecomms.bsky.social 🧵Key insights detailed below. www.nature.com/articles/s41...