Marleen Bérouti
@marleenberouti.bsky.social
📤 65
📥 97
📝 2
PhD student in Veit Hornung's lab in Munich.
pinned post!
I am very excited to share the second paper of my PhD published in
@cp-cell.bsky.social
. Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor
@v-hornung.bsky.social
for their great support and collaboration!
www.cell.com/cell/fulltex...
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Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900619-1
3 months ago
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reposted by
Marleen Bérouti
Pavel Kielkowski
10 days ago
The final version of our article about PLD3 AMPylation is now out
shorturl.at/iTxWx
. One protein, many proteoforms. Congratulations to Laura and thanks to
@marleenberouti.bsky.social
@v-hornung.bsky.social
@jaelab.bsky.social
@hellmichgroup.bsky.social
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reposted by
Marleen Bérouti
Ivan Zanoni
about 1 month ago
#InterferonPower
! Thrilled for our latest work
@cp-cell.bsky.social
! With
@danielboehmer.bsky.social
, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉)
#interferons
! Free👉
authors.elsevier.com/a/1leKGL7PXu...
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reposted by
Marleen Bérouti
Tobias Komar
about 2 months ago
Excited to share the first paper of my PhD, published in the Journal of Biological Chemistry. Huge thanks to all authors, especially to co-first author Stefan Bauernfried, Alex Horswill‘s lab and
@mannlab.bsky.social
, and my supervisor
@v-hornung.bsky.social
.
www.jbc.org/article/S002...
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Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus
Interleukin-1β (IL-1β) is a pivotal mediator of innate immunity, essential for orchestrating the acute inflammatory response. While the canonical activation of IL-1β involves cleavage of its inactive ...
https://www.jbc.org/article/S0021-9258%2825%2902425-1/fulltext
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reposted by
Marleen Bérouti
Gene Center Munich @LMU Munich
3 months ago
🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner!
www.cell.com/cell/fulltex...
@v-hornung.bsky.social
@m-berouti.bsky.social
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Innate immune system: How modified RNA tricks the immune system
Researchers at LMU have elucidated why certain RNA modifications do not trigger an immune response—a key mechanism for RNA therapeutics.
https://www.lmu.de/en/newsroom/news-overview/news/innate-immune-system-how-modified-rna-tricks-the-immune-system.html
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I am very excited to share the second paper of my PhD published in
@cp-cell.bsky.social
. Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor
@v-hornung.bsky.social
for their great support and collaboration!
www.cell.com/cell/fulltex...
loading . . .
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900619-1
3 months ago
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26
11
reposted by
Marleen Bérouti
Cell - a Cell Press journal
3 months ago
Now online! Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
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Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds that poor nuclease processing and selective TLR avoidance drive this evasion, offering insight into the molecular basis of immune tolerance to pseudouridine-containing RNA.
http://dlvr.it/TLbY2b
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reposted by
Marleen Bérouti
Gene Center Munich @LMU Munich
4 months ago
Wow, so cool!🌟 Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy 🥂🥳🤩
www.lmu.de/en/newsroom/...
@v-hornung.bsky.social
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NUCLEATE Cluster of Excellence: beacon of nucleic acid research
The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.
https://www.lmu.de/en/newsroom/news-overview/news/nucleate-cluster-of-excellence-beacon-of-nucleic-acid-research.html
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reposted by
Marleen Bérouti
Louis-Jeantet Foundation
6 months ago
Sneak preview: watch the teaser of VEIT HORNUNG
@v-hornung.bsky.social
@genecenter-lmu.bsky.social
🎞️
youtu.be/Q_YCcZj6h8o
Join us next week for the
#LJFPrizes
Lectures: 📆9th April 16h30 📍Auditoire Alex Müller (A250), Centre Médical Universitaire, Genève
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Teaser Veit Hornung
YouTube video by Fondation Louis-Jeantet
https://youtu.be/Q_YCcZj6h8o
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reposted by
Marleen Bérouti
Journal of Experimental Medicine
8 months ago
Gomez-Diaz,
@v-hornung.bsky.social
et al. show that mice lacking RNase T2 display an inflammatory phenotype in a TLR13-dependent manner, even under germ-free conditions, suggesting that RNase T2 plays an important role in limiting self-RNA recognition
https://buff.ly/4jG49Gy
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reposted by
Marleen Bérouti
Journal of Experimental Medicine
8 months ago
New: Sato, Miyake @UTokyo_News_en and colleagues report that the lack of RNase T2 activates TLR13, the sensor of bacterial 23S ribosomal RNAs, leading to the accumulation of tissue-protective Kupffer cells.
https://buff.ly/4hw6kL0
Companion study by
@v-hornung.bsky.social
https://buff.ly/4jG49Gy
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reposted by
Marleen Bérouti
Rebsamen Lab @UNIL
8 months ago
Excited to share our latest paper out today in
@naturecomms.bsky.social
! Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.
#ImmunoSky
#InterferoSky
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The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications
TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...
https://www.nature.com/articles/s41467-024-55692-y
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reposted by
Marleen Bérouti
Louis-Jeantet Foundation
9 months ago
VEIT HORNUNG
@v-hornung.bsky.social
@genecenter-lmu.bsky.social
is awarded the 2025 Collen-Jeantet Prize for Translational Medicine for his important contributions to our understanding of how foreign nucleic acids and other non-self signals trigger the innate immune system.
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