@xlahaye.bsky.social
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reposted by
Nicolas Manel Lab
9 months ago
Thrilled to share our latest
@cp-cell.bsky.social
. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
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Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...
https://www.cell.com/cell/abstract/S0092-8674(25)00556-2
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Excited to share our latest update on
@cp-cell.bsky.social
! We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses.
www.cell.com/cell/abstrac...
loading . . .
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...
https://www.cell.com/cell/abstract/S0092-8674(25)00556-2
9 months ago
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