Hoda Kooshapour
@kooshapour.bsky.social
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reposted by
Hoda Kooshapour
Helmholtz Institute Würzburg
21 days ago
Check out the latest paper by
@carmen-aguilar.bsky.social
, which also involved our
#HIRI
group leader
@emmanuel-saliba.bsky.social
and his lab. It was recently published in
@natmicrobiol.nature.com
:
doi.org/10.1038/s415...
Congratulations to all authors! 👏🎉
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reposted by
Hoda Kooshapour
Osman Lab
20 days ago
Our new paper is out 🎉 in
@narjournal.bsky.social
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls
#mtDNA
copy number by regulating Lon-dependent substrate turnover in
#yeast
. Congrats to
@simonrecyclable.bsky.social
, all co-authors and collaborators!
academic.oup.com/nar/article/...
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Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Abstract. Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces c
https://academic.oup.com/nar/article/54/2/gkaf1390/8425365
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reposted by
Hoda Kooshapour
Westermann Lab
about 1 month ago
RIL-seq boosts the study of sRNAs. Here comes its first application to intracellular bacteria. Plus, 10 years after its characterization, we now present an RNA sponge of Salmonella PinT. Congrats to
@kooshapour.bsky.social
& great collaboration w/
@jorg-vogel-lab.bsky.social
!
doi.org/10.1093/nar/...
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Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT
Abstract. Salmonella virulence chiefly relies upon two major pathogenicity islands, SPI-1 and SPI-2, which enable host cell invasion and intracellular surv
https://doi.org/10.1093/nar/gkaf1364
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reposted by
Hoda Kooshapour
Jörg Vogel
5 months ago
Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today.
nature.com/articles/s4158…
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reposted by
Hoda Kooshapour
Westermann Lab
4 months ago
Congrats to Ann-Sophie Rüttiger who successfully defended her PhD this week! 🎓 She focused on global RNA-binding proteins in Bacteroides—bacteria lacking Hfq, ProQ, CsrA, Khp—culminating in the discovery of a post-transcriptional network governed by RbpB (
www.nature.com/articles/s41467-024-55383-8
).
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reposted by
Hoda Kooshapour
Westermann Lab
5 months ago
New preprint from the lab, in collaboration with Wenhan Zhu (U Vanderbilt): using dual RNA-seq during B. theta colonization of the host mucous layer, we identify IroR--an iron-response sRNA that tunes capsule expression and facilitates adaptation to iron limitation.
doi.org/10.1101/2025.09.08.672848
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An RNA regulates iron homeostasis and host mucus colonization in Bacteroides thetaiotaomicron
Symbiotic bacteria in the human intestinal microbiota provide many pivotal functions to human health and occupy distinct biogeographic niches within the gut. Yet the molecular basis underlying niche-s...
https://doi.org/10.1101/2025.09.08.672848
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reposted by
Hoda Kooshapour
James Connolly
6 months ago
Absolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.
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Convergent evolution of distinct D-ribulose utilisation pathways in attaching and effacing pathogens - Nature Communications
Cottam et al. identify distinct pathways for D-ribulose utilisation in pathogenic Escherichia coli and Citrobacter rodentium, providing mechanistic details and suggesting convergent evolution towards ...
https://www.nature.com/articles/s41467-025-62476-5
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reposted by
Hoda Kooshapour
Westermann Lab
6 months ago
Latest preprint from the lab:
doi.org/10.1101/2025...
In this study lead by
@lenaamend.bsky.social
from the group, we explore carbon cross-feeding between a gut commensal and an enteropathogen. Can we counter infection by cutting sugar supply to pathogens?
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Ablation of polysaccharide breakdown in Bacteroides thetaiotaomicron prevents cross-feeding and growth of Salmonella Typhimurium in the mouse gut
Pathogens invading the intestine compete for nutrients with the resident microbiota. However, there is evidence that commensal members of the gut also provide nutritional resources to enteropathogens ...
https://doi.org/10.1101/2025.08.08.669261
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reposted by
Hoda Kooshapour
Emma Dunne
8 months ago
Bullying is rife in academia. But in Germany, structural and legal systems enable and embolden a few bad eggs who choose to abuse their power. Shining a light on these problems is painful for those affected, but is an important step on the long road to reform 🧪
www.nature.com/articles/d41...
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Can Germany rein in its academic bullying problem?
Researchers and administrators are exploring ways to restructure a rigid hierarchy that can breed power abuses.
https://www.nature.com/articles/d41586-025-01207-8
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reposted by
Hoda Kooshapour
Westermann Lab
10 months ago
Some say, important sRNAs can be recognized by having their own “sponge” 🧽. Well, here comes InvS: a sponge of PinT (and vice versa). Congrats to
@kooshapour.bsky.social
and
@ginlaca.bsky.social
on their great work!
doi.org/10.1101/2025...
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Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT
Salmonella virulence chiefly relies upon two major pathogenicity islands, SPI-1 and SPI-2, which enable host cell invasion and intracellular survival, respectively. There has been increasing evidence ...
https://doi.org/10.1101/2025.04.07.647523
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reposted by
Hoda Kooshapour
Jonathan Jagodnik
10 months ago
A new RIL-seq experiment, now to study host-pathigen interactions! Congrats to the
@westermannlab.bsky.social
and colleagues!
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reposted by
Hoda Kooshapour
Jonathan Jagodnik
10 months ago
I am thrilled to share this new preprint from our lab! We find (>800!) 30S binding sites in hundreds of 5'UTRs, but also new dynamic steps of translation initiation.
www.biorxiv.org/content/10.1...
Congrats to all co-authors at the RNA control of gene expression lab, IBPC CNRS (Thread, 1/6)
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30S-seq redefines the bacterial Ribosome Binding Site
The translation initiation step is rate limiting for the efficiency of gene expression in all organisms. However, the mechanism of ribosome recruitment to mRNA start sites strikingly differs between e...
https://www.biorxiv.org/content/10.1101/2025.04.04.647229v1
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reposted by
Hoda Kooshapour
Mona Alzheimer
10 months ago
New preprint from
@westermannlab.bsky.social
about a pair of antagonistic
#Salmonella
sRNAs. Check it out 👇🏻
add a skeleton here at some point
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reposted by
Hoda Kooshapour
Jörg Vogel
10 months ago
If you want to do single-cell RNA-seq on your favourite bacterium, here‘s our detailed Nature Protocol for microbial MATQ-seq. It profiles up to 600 genes in a single bacterial cell!
www.nature.com/articles/s41...
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Transcriptomic profiling of individual bacteria by MATQ-seq - Nature Protocols
Bacterial single-cell sequencing via MATQ-seq combines index sorting, random priming and rRNA depletion, and offers high cell retention and transcript capture rates, making it ideal for experiments wi...
https://www.nature.com/articles/s41596-025-01157-5
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reposted by
Hoda Kooshapour
bioRxiv Microbiology
10 months ago
Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT
https://www.biorxiv.org/content/10.1101/2025.04.07.647523v1
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