Happy to share that the last first-author paper from my doctoral research was featured on the cover of @narjournal.bsky.social academic.oup.com/nar/issue/54/2 It was exciting to paint the cover artwork, reflecting how our research combined wet-lab experiments with inputs from structural predictions.

Our new paper is out 🎉 in @narjournal.bsky.social A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast. Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators! academic.oup.com/nar/article/...

Our study on the molecular function of translational activators for mitochondrial protein synthesis is published: rdcu.be/eSWxT A great collaboration with @stirlingchurchman.bsky.social and @sshaolab.bsky.social with structural work from our @pelleeas.bsky.social Funded by @kawresearch.bsky.social

I found these immune cells just finished mitosis but their midbody is still yet to be resolved. How cool? If you zoom in to the midbody, you can see its classical shape just like in the textbooks. I love these little details.

Online now - the Review "Interconnectivity of mitochondrial protein biogenesis and quality control" from @mitolab.bsky.social et al. #ProteinImport #Proteaes #Proteolysis #Proteostasis Read it here: authors.elsevier.com/sd/article/S...

🏅We congratulate 🌟Nils Bertram🌟 @lmumuenchen.bsky.social, on winning a FEBS Letters #PosterPrize at the #EMBOFEBSproteostasis meeting, held in Espoo, Finland! 🎉👏👏👏 📸 Photo: Nils with our Managing Editor, Dr. Duncan Wright

I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

Excited to share our new preprint on Mrx6, who binds the Lon protease Pim1 N-terminal domain through a bipartite motif to confer selective substrate specificity and regulate mtDNA copy number! Looking forward to all your feedback and follow-ups! A huge thank you to everyone who contributed!

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1

Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance. www.embopress.org/doi/full/10....

Mitochondria (top) and microtubules (bottom) in a cell videoed through a microscope. #Science #Biology #CellBiology #microscopy

Something you don't see every day! Digitizing the human proteome in >53,000 individuals with 15-year follow-up and, with machine learning, unraveling nearly 500 disease-causing proteins www.cell.com/cell/fulltex... open-access

NEW: 2024 has just been confirmed as the warmest year on record, and the first to breach the 1.5C threshold. We used a ridgeline (Joy Division inspired) chart to visualise daily temperature anomalies since 1940. 2024 clearly stands out with 100% of its days above 1.3C and 75% above 1.5C.

Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @jcellbiol.bsky.social! A wonderful early present to see this now online! rupress.org/jcb/article/...

One big advantage of laser induction is you can cause pearling whenever you want, in just the mitochondrial tube that you want, so it is very precise and controllable. Combined with STED imaging it has been possible to get some beautiful images of cristae and nucleoids during pearling

The transient nature of pearling makes it hard to detect - in normal cells you might need to sit and watch one spot for a long time and then, if you blink, you'll miss it

He found that pearling was ubiquitous, occurring in every cell type that he has looked at, including: U2OS, Hek293, COS7, RPE1, Jurkat, primary human fibroblasts primary CD8 T-cells, iPSC derived neurons, and budding yeast (shown here).

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

Pearling Drives Mitochondrial DNA Nucleoid Distribution https://www.biorxiv.org/content/10.1101/2024.12.21.629917v1

EXTRA! EXTRA! Read all about it! Latest SGD newsletter! www.yeastgenome.org/blog/sgd-new... - AlphaFold - YeastMine - Community wiki - SGD’s new GENETICS publication - New yeast microPublications - Alliance of Genome Resources 7.4 - Give a Gift/Support SGD - Upcoming conferences - Happy Holidays!

Delighted to share our new preprint on the cell biology and genome of Stentor pyriformis, a giant ciliate that maintains Chlorella endosymbionts in surface-associated microtubule baskets. www.biorxiv.org/content/10.1...

Membrane blebs forming from the plasma membrane of a cell videoed through a microscope. If the bleb gets big enough, mitochondria, enter and explore. The cell is at the bottom where many mitochondria (bright signal) surround the nucleus (lack of signal). #Science #Biology #CellBiology #microscopy

How to improve memory and cognitive function in aged mice Fix the mitochondrial EC (excitation-coupling) @science.org representing a new potential path for replenishing neuronal energy reserves to counter brain aging www.science.org/doi/10.1126/...

Think mitochondria are networks of cylindrical tubes? not always! Check out poster by @gavsturm.bsky.social "Mitochondrial Pearling: an emerging class of organelle dynamics explained by a biophysical pearling instability" tomorrow Sunday Dec 15 11:45-12:45 B145

Justyne Odgahl successfully defended! Her paper was also just accepted at JBC, check it out to learn about allostery and DNA binding in the Lon protease! #microsky www.jbc.org/article/S002...

Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans 🧪 www.cell.com/cell-metabol...

High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...

DNA sequence and lesion-dependent mitochondrial transcription factor A (TFAM)-DNA-binding modulates DNA repair activities and products academic.oup.com/nar/advance-...

We just published a study on the first endogenous cysteine-free interactor of the mitochondrial disulfide relay - HAX1. HAX1 relies on MIA40 for folding and stability and does not require the redox fxn of MIA40. Nice collaboration w/ #ulrichlab. doi.org/10.1111/febs...

Again, glutathione comes to the rescue. In yeast, Tsa1 oxidizes glutathione at moderate H2O2 concentrations when the TRX system becomes inactivated by oxidation. A study together with the Morganlab and the Depontelab. doi.org/10.1016/j.fr...

Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance www.nature.com/articles/s41...

A community consensus paper about a contentious subject like the Last Eukaryotic Common Ancestor does feel very bluesky in late 2024 doesn't it? It was pretty fun to write. Hopefully you'll have fun reading it:) Kudos to @Tom Richards for his writing and cat herding abilities! plos.io/4g0alq4

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀 @chrisfrank662.bsky.social , Dominik Schiwietz, Lara Fuss, Hendrik Dietz www.biorxiv.org/content/10.1...

Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice | preprint from the Nils Göran Larsson group www.biorxiv.org/content/10.1...

Cytoplasmic mtDNA clearance suppresses inflammatory immune responses www.cell.com/trends/cell-...

MagLOV! MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social. We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!). bsky.app/profile/addg...

Happy #FluorescenceFriday ! Let's celebrate with a colorful image of a developing ventral spinal cord of a 🐣 embryo. #neuroscience #microscopy

Interesting paper from the Lackner Lab on the connection between mitochondrial dynamics and mtDNA. doi.org/10.1091/mbc....

AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact https://www.biorxiv.org/content/10.1101/2024.11.20.624606v1

Did you know that orchids have a big chunk of fungal mtDNA stuck in their own mitochondrial genomes?? In this new preprint, we found that fungal-derived tRNAs are functional in the orchid mitochondria. www.biorxiv.org/content/10.1... 1/4

How do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography www.biorxiv.org/content/10.1...

PhD Opportunity Alert!🚨Please share! Our lab is hiring a #PhD student! Join us in investigating #MitochondrialProteostasis and its role in #Ageing. More Information here 👉 kohler-mitolab.com/join #PhDPosition #Mitochondria #Science #JobOpportunity