🚨 𝗕𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝗻 𝗖𝗔𝗥 𝗧-𝗰𝗲𝗹𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝘆! Roswell Park researchers have developed IL-36 gamma “armored” CAR T cells that reprogram neutrophils to attack solid tumors. 🔗Read the full press release here: roswellpark.org/newsroom/202... #CARTCells #RoswellPark

2025 Albert Lasker Basic Medical Research Award winner Steven McKnight describes discoveries that exposed the structures and functions of low-complexity domains within protein sequences. ja.ma/4hoxpRg

“I believe he has ideas about becoming a scientist; on his present showing, this is quite ridiculous.” A privilege to have known John. He always listened to what one had to say with great intent. If you knew him, you know what I mean. 🧪 www.nature.com/articles/d41...

I wrote a really cool grant this week.

Wise cartoon posted outside a @princetonneuro.bsky.social PhD student office. Let’s all remember to enjoy the journey today (and all days).

new out in Nature www.nature.com/articles/s41...

📣 CRISPR had its day... meet Bridge RNA recombinases from the brilliant Patrick Hsu lab - 3rd Generation Gene Editing is HERE! 🔥🔥🔥🔥🔥🔥🔥 www.science.org/doi/10.1126/...

new out in Nature www.nature.com/articles/d41...

Look at this cute little guy! #lakelife

If you think a golden ballroom is more important than childhood cancer research… I have nothing left to say to you. Please unfollow me. #pediatriccancer #cancermom

🧬🧪 @science.org RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/... @puckknipscheer.bsky.social @simonelsasser.bsky.social + al. @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social #DNA #RNA #genome #G-quadruplex #G-loop

I learned this week that my MPI prostate cancer disparities R01 will be terminated this September at the end of year 1. Sounds like they are killing the whole disparities NOFO it was awarded under. Sigh… I am not surprised. I just hate all of this.

Wow, 7% depressing. In other news, please check your compiled grants in ERA Commons. 129 pages of our P50 missing going between the final preview of submitted Grant in ASSIST to the compiled grant in Commons. No errors. Put in ticket. Fixed. Still 2 pages missing. The NIH is not alright. 🙁

Out @nature.com: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations doi.org/10.1038/s415... 🧵

Epic review on all things cell surface-ome, great resource for the community 🙏

Just had the pleasure of sitting in front of a dental hygienist dispensing medical advice to their seat mate with the confidence of a heart surgeon, pharmacist, and neurologist all rolled into one. Thank God it was only a 1 hour flight. ✈️

The cognitive dissonance required to do (and enjoy) regular fun Friday night things things in the world today is mind boggling. And necessary. Alcohol helps.

For those who want to help. gofund.me/4abf93f0

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

@mikefeigin.bsky.social you have no idea the power you have on this site. I like one pizza week post from you and now I have an entire feed of pizza photos from around the world. In other news, now I want pizza for breakfast.

Hello Buffalo friends! It’s rally for science time! March 7, 2-6PM, Niagara Square! Sign up below and please spread the word! www.eventbrite.com/e/stand-up-f...

Does anyone know if conversion from K99 to R00 requires council approval and/or evidence for likelihood of this going forward in current climate at #nih? Trying to figure out how to advise post-docs RE: conversion timing and to keep our faculty search moving forward. @jeremymberg.bsky.social?

American science is under attack Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪 “Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling” www.nytimes.com/2025/02/14/o...

🚨 New paper alert! 🚨 Excited to share our latest work in Nature Communications spearheaded by brilliant @omaiques.bsky.social and thanks to all our collaborators—we show how matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory that supports metastasis! 🧵⬇️

Really enjoying my required protecting PHI and avoiding conflict of interest ethics training today.

Proud to share: "Ensemble docking for intrinsically disordered proteins" from Dartmouth undergrad Anjali Dhar 24' and grad student Tommy Sisk. We present ensemble docking strategies for IDPs that, remarkably, seem to work! www.biorxiv.org/content/10.1... Code: github.com/paulrobustel...

I love my students! And they know I need coffee. These were my two favorite holiday gifts this year. Just pausing for a minute in all the madness to refocus on why we all do this.

Thrilled to share our latest study on how mechanical forces drive cell competition! Congratulations to @andreasschoenit.bsky.social, S. Monfared, and L. Anger. Curious about active boundaries, stress fluctuations, and intercellular forces in cell competition? 👇 www.biorxiv.org/content/10.1...

One of the articles that will be remembered as key evidence linking the systemic metabolism and epigenetic regulation of T cell function - methionine transporter activity controls H3K79M2 levels www.nature.com/articles/s41...

It’s been 20 years today since my first paper on intrinsically disordered proteins Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations doi.org/10.1021/ja04... and I thought I would tell the somewhat random path that led to this paper. 1/n

Our paper out in eLife. Full-length direct RNA #nanopore sequencing uncovers 5' #RNA shortening upon cellular #stress that depends on ✅ stress-granules and #XRN1 but ❌ not poly(A) or cap removal elifesciences.org/articles/96284 🤔 useful to further reduce translational load during #ISR? #RNAbiology

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing Huge work from the @brunetlab.bsky.social www.nature.com/articles/s41...

First act of self-care for 2025: I just blocked off December 15th to January 2nd on my calendar next year. No more people trying to cram in meetings before the end of the year. Never again.

Sharing this so I can buy all of these for my lab!

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain) www.science.org/doi/10.1126/...

An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung www.science.org/doi/10.1126/... @science.org @morriseylab.bsky.social

New NCI K32. Up to $80K for salary. $30K/yr research development. US citizenship NOT required. 🧪 grants.nih.gov/grants/guide...

Relevant to many here — As of Dec 10, NCI is discontinuing the F32 and encouraging postdocs to apply for a K32 ACE award instead. grants.nih.gov/grants/guide... grants.nih.gov/grants/guide...

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏 academic.oup.com/nar/advance-...

Are you a senior PhD student or postdoc? Do you have a cool science story to tell? Do you want to visit Buffalo when the weather is perfect? Then apply for the Emerging Leaders Seminar Series at Roswell Park! DM or email me with questions. (RT please!) www.roswellpark.org/education/pr...

Wow!!! This looks fantastic! Congrats @ettwiller.bsky.social and NEB. Look forward to this going to market

Day 2 of #ASH24 (12/8) is officially behind us, and we’re gearing up for one more exciting day to wrap up this incredible event! Don’t miss your chance to connect with us at booth 3147 one last time today—we can’t wait to see you!

Years ago, when my fiancé moved in, this adorable little guy went around peeing on his clothes to attempt to assert his dominance. It was messy and accomplished nothing. Dealing with a collaborator who is behaving similarly (metaphorically, of course). So sad, during what should be a happy time. 🙁

Have had some good chats recently about pivoting to non-profit and society journals. A point to share/underline is that such options exist across the "prestige" spectrum. Some examples in the image. All heavily subjective of course; would love to hear thoughts from others!

Feeling grateful that I don’t belong to any societies that hold a December annual meeting. How are you all managing this in addition to the mad end of year rush?

Statistical and computational methods for enabling the clinical and translational application of spatial transcriptomics 🧬🖥️ 🧪 onlinelibrary.wiley.com/doi/10.1002/...

Just recently I wrote an opinion piece with Shingo Kajimura, based around the idea that adipocytes, besides having energy storage/endocrine function, also act as immune hubs #Immunosky 🧪 1/🧵 febs.onlinelibrary.wiley.com/doi/10.1111/...

Congrats to a very talented post-doc in my lab, Mohamed, on submitting his first F32 application today! Here’s to hoping reviewer #2 is in a good mood a few months from now.

🧪 Mayo Clinic integrated genetic test insights into EHRs for 100,000+ patients, identifying 2,000 with risk variants. A new genetic data repository aims to drive research and innovation. 🧬🖥️