Getting there.. #everydayimwaffling

Ready for some heavy lifting 🪡

3dem madness 😅

Through proteomic profiling of our proprietary compound library, our team identified a selective, fast, and potent molecular glue degrader that induces cereblon degradation via a novel mechanism. Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk

Every day I’m wafflin’ 🎶

Carboxylases are the best 🥰

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬 The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

What is the weight of an EM grid? 🤔

New toy installed 💥🧊

Amazing, I wonder how many people are now sprinting back to some of their old data sets of small particles that they could never successfully process.. err, i have to go 🏃‍♂️💨

Yes great, new grid boxes that have no space to write on. With lids that no standard tool can open. 👍

Received program for amazing cryo-EM symposium 👍 It’s on a Saturday, 9-5 🤦🏻‍♂️

Indulged in the popular German New Years Eve tradition of watching Dinner for One - you may wish to indulge, or not youtu.be/2pbJlHMpUlU?...

Woohoo congrats!

My UBR4, despite being very active, always looked like garbage on the grids. Need to dig in here to find the secret sauce! Congrats to @micharapelab.bsky.social lab et al

Nice 🥳

New #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky. www.biorxiv.org/content/10.1...

When are there too many starter packs? 🤔

Hello @subAngstrom, where art thou?

No answer on the other platform, so I ask here again: Is the 3DFSC server working for anybody?

Over 4 years in the making, I am extremely happy to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells: www.biorxiv.org/content/10.1...

Stuff’s glowing..

Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksC

Did I miss something?

Opening for an awesome group leader to join our community on the 5th/6th floor of the @biozentrum. We're looking for someone who brings an exiting biological program using a combo of structural biology, cellular imaging, and biophysics. Come join us!!🧪🧶🧬🔬👩‍🔬 www.biozentrum.unibas.ch/open-positio...

Interesting 👍🏻

Read tomorrow's Nature to find out what we think 7 years of solving #cryoEM structures of brain-derived #amyloids has taught us about neurodegeneration, and where to go from here. With Michel Goedert and Ben Ryskeldi-Falcon, and very grateful to present and past group members. rdcu.be/dnaXd

Hello 🫡

So how does this work?