loading . . . Light-responsive DNA nanostructures Nature Reviews Chemistry, Published online: 13 April 2026; doi:10.1038/s41570-026-00817-8Light-responsive chemical modifications enable precise, stimuli-controlled reconfiguration of DNA nanostructures, enhancing stability, programmability and functional versatility. These advances expand applications in diagnostics, delivery, data storage and nanoscale engineering. Emerging design strategies and new photochemical tools driving the field forward are highlighted. http://dlvr.it/TS18SX