Nature Reviews Chemistry (@natrevchem.nature.com)

Molecular bioengineering of functional nucleic acids Nature Reviews Bioengineering, Published online: 17 October 2025; doi:10.1038/s44222-025-00361-yFunctional nucleic acids (FNAs) achieve specific target recognition, molecular binding and catalytic activity by folding into defined secondary and tertiary structures. This Review focuses on two major classes of FNAs — aptamers and DNAzymes — and discusses their structural features, production strategies and engineering approaches as well as their clinical applications in diagnostics, targeted therapy and precision medicine. https://www.nature.com/articles/s44222-025-00361-y?utm_source=bluesky&utm_medium=social&utm_campaign=natrevbioeng