Nature research paper: Targeting FOXM1 condensates reduces breast tumour growth and metastasis https://go.nature.com/4g7BNC8

Y'all, there is now a Paperpile extension for Word. This should be useful for a lot of us who have heavy Word users and heavy Google Doc users on the same writing teams. paperpile.com/word-plugin/

1/ In March 2023, I received a lumbar puncture. This was key to receiving my chronic inflammatory demyelinating polyneuropathy #cidp diagnosis. This 🧵 is on my experience with identifying and treating #autoimmunedisease. I'll also be sharing some 🧵s I posted previously on the Other Place.

An interesting read on the alternative history of GLP1 www.nytimes.com/2024/12/25/o...

Cellular RNAs directly regulate the activity of an antiviral immune signaling complex www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... @science.org @nandangokhale.bsky.social @ramlabuw.bsky.social

The life of each of us began when a sperm and an egg came together. But what happens at a molecular level? Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11) www.cell.com/cell/fulltex...

RNA looping!

We have dramatically increased the activity of splice switching *and* RNase H-active antisense oligonucleotide #ASO therapeutics by conjugating a nuclear importer 🧬💊! Preprint led by Disha #chemsky 🧪 @uclchemistry.bsky.social @oxfordchemistry.bsky.social chemrxiv.org/engage/chemr...

We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs. You can check out our pre-print here: tinyurl.com/27p7hyt9, and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? www.nature.com/articles/s41...

www.cell.com/cell/fulltex... #snoRNA #RNAsky #RNA

Nifty, innovative approach

Came to a new understanding of 'colocalization' since starting STED microcopy: there is no colocalizaiton, objects cannot occupy the same physical space!

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

A report made counterintuitive claims that PRC2 binds → more RNA than PTBP1 & hnRNPU → RNAs that do not exist in the cell We found a simple explanation: the authors ignore most RNA in the sample, leading to inflated background & misleading conclusions. www.biorxiv.org/content/10.1...

Missed the woodpecker sweep by 1 at Green-Wood Cemetery this morning. Tallied Yellow-bellied Sapsucker, Red-headed Woodpecker, Red-bellied Woodpecker, Downy Woodpecker & Northern Flicker. Oddly, Hairy Woodpecker is rare here despite breeding at nearby Prospect Park #birds #birdsNYC

REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers. New preprint from a collaboration led by Grace Bower and Evgeny Kvon. doi.org/10.1101/2024...

I've been meaning to write a lengthy thread about our experiences with DNA methylation editing in mouse ESCs if that would be useful (or interesting?) for a niche audience here. tl;dr: it was frustrating but we learned a lot, and it ended with our shiny new pub (1/17) www.nature.com/articles/s41...

A beautiful example of mRNA-mRNA interaction demonstrating architectural role for RNP granule formation. www.nature.com/articles/s41...

Happy to announce our new preprint "A green lifetime biosensor for calcium that remains bright over its full dynamic range" which is now available on bioRxiv: www.biorxiv.org/content/10.1... Why yet another biosensor for Ca2+? Here's a thread 🧵