Check out our new poster that highlights the #cryoET workflow, from vitrification and cryo-FIB milling to 3D imaging and computational reconstruction. #TeamTomo 👉 Download the poster: ter.li/erzx0qmh

Structures of asymmetric particles of tick-borne encephalitis virus provide insight into flavivirus assembly and maturation www.science.org/doi/10.1126/...

From v0.2.0 MissAlignment now has an inference mode where you can apply the trained models from one dataset to a new dataset to skip training time. I haven't tested it extensively, so double check if the results look decent 😉 The program calls changed slightly, see here: github.com/warpem/miss-...

🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

Inspired by Utz, I ported the old Briggs lab tools to ChimeraX in a single bundle named Geopickr, with some extra utilities (geopicking on morphometrics surfaces!). I've submitted it to the toolshed, but in the meantime: github.com/baradlab/Geo...

Cryo-ET gives unparalleled views of cellular structures, but targeted sample preparation by cryo-FIB milling has been a constraint. No longer! A new workflow yields close to 100% targeting success for centrioles & other small structures. Read the preprint ⤵️ www.biorxiv.org/content/10.6...

After all this time looking for it! #humor #math #foundontheinternet #nerdhumor

You can take a look at a demo tomogram acquired with the xLPP of apo-ferritin on the cryoET data portal here: cryoetdataportal.czscience.com/datasets/10496 Raw data is of course also available for download!

Academic writing should be addressed neither to the public nor to other academics. It should be addressed to a single interlocutor with whom you have a petty rivalry and whose work you are trying to discredit

Direct interactions between the cell’s powerhouses and nuclear pores might channel energy straight into the nucleus, fuelling cell division and differentiation. go.nature.com/43n6Fun

The results here re 3D classification are quite impressive. Would be interesting to see how much the LPP improves classification of near-native samples with extreme compositional heterogeneity (e.g. derived from cellular fractions)

Schwartz, Ermel, Owens, Zhao, Peck, Hart, Jensen, Carragher, Kimanius: POPSICLE: Benchmark Datasets for Segmentation and Localization in CryoET https://arxiv.org/abs/2606.10255 https://arxiv.org/pdf/2606.10255 https://arxiv.org/html/2606.10255

Cryo-EM: the revolution continues doi.org/10.1107/S205...

Characterization Standard for In-situ Cryo-electron Tomography pubmed.ncbi.nlm.nih.gov/42239035/ #cryoem

Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines. 🧵👇 doi.org/10.1002/pro.70578

AreTomoLive: a preprocessing pipeline for cryo-ET that streamlines tomographic alignment, reconstruction and contrast enhancement. www.nature.com/articles/s41...

Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...

Important new results from lab alumnus Hui Guo @mydange.bsky.social, now a postdoc in the @briggsgroup.bsky.social, out on bioRxiv.

Why do influenza viruses make ludicrously long filamentous virions? Probably lots of reasons, but in a new study Lu Liu et al. provide evidence for an appealing hypothesis: filaments are more stable in acidic solutions and hence survive for longer in aerosols www.nature.com/articles/s41...

It's finally out! Molecular architecture of mammalian AP3:ARF1 carriers - a mechanism for lysosomal membrane protein trafficking - from a combination of #biochemistry, #cryoET and #cellbiology 📝 Paper: www.science.org/doi/10.1126/... 🧵 Thread: subsequently #teamtomo #membranetrafficking

Recent advances in integrative cryoEM/ET toward visualizing the molecular sociology of cellular organelles pubmed.ncbi.nlm.nih.gov/42134003/ #cryoem

In situ single-particle Cryo-EM methods: Principle and applications pubmed.ncbi.nlm.nih.gov/42134001/ #cryoem

Wow - this is just amazing. Hui Guo and colleagues from John Briggs’ lab use cryoEM helical reconstruction to discover how filamentous influenza virion assembly is directed by multiple conformations of M1 - explaining how NA is concentrated at the proximal pole. www.biorxiv.org/content/10.6...

Tomo conference abstract deadline: May 14! Already a great lineup of speakers chaired by @erwright73.bsky.social See more details at the link below.

The 11th International #teamtomo Congress is coming to Madison, Wisconsin! As a proud Madison native, I can confirm: August 9–12 is peak Wisco weather ☀️ stoked for exciting science, friendly people, and warm nights @ the Union Terrace Abstract deadline: May 14 cryoem.wisc.edu/11th-interna...

Hepatitis B: A Review jamanetwork.com/journals/jam...

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

We summarize our findings in an animation made in partnership with @jiwasa.bsky.social detailing the process of coronavirus entry into cells 14/19

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

The cartwheel was first visualized ~70 years ago in the symbiont Trichonympha in the wood termite gut. We’ve discovered the cartwheel’s secret: a unique zigzag stacking of SAS-6 tetramers that facilitates the iconic 9-fold symmetry of cilia. #cellbiology #teamtomo #SAS6 #cartwheel

Really excited to be able to share our latest preprint, describing how during its evolution in cattle, H5N1 has got better at using a type of alternative receptor that's abundant in cows, but not found in humans and birds. www.biorxiv.org/content/10.6...

Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @minhuanli.bsky.social and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...

Registration is open for the FASEB Virus Structure & Assembly meeting! Join us for exciting sessions on pandemic viruses, virus structure and replication, antiviral and bacteriophage therapies, and cutting-edge technologies. Short talks will be selected from submitted abstracts. #VirStrucSRC

Great day at NYSBC, thanks for having me! 😊 If anyone wants to try out the tutorial, here it is: www.dropbox.com/scl/fi/054cm... There are linked videos for each step in the PDF, or I have also prepared the whole thing as a .PPT with embedded videos (2.7GB): www.dropbox.com/scl/fi/jnl9h...

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

started using --𝐬𝐢𝐠𝐦𝐚_𝐚𝐧𝐠 𝟑 in RELION5 Refine3D and all of a sudden every subtomogram average goes to high resolution 🤯 #TeamTomo

Join #EMBOCryoEM to get a comprehensive foundation in advanced single-particle and cellular tomography techniques – we'll cover the entire workflow from sample preparation to data collection and image processing. https://s.embl.org/cry26-01-bl Apply by: 11 May 2026 @embo.org

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

Check out this beautiful study, spearheaded by Kenny @denkenny.bsky.social, on mitochondrial remodeling. Some of the prettiest organelle segmentations I have seen 😍😍😍 www.science.org/doi/10.1126/...

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

Amazing work from Clay @kosonocky.bsky.social, Alex Abel and LEAH labs, and all the collaborators and participants in the Bits2Binders AI CAR-T therapy protein design competition. The results are in! bsky.app/profile/koso...

Results from an impressive world-wide binder design competition.

A bit late to post, but check out this peer-reviewed version at PNAS 2025 here: www.pnas.org/doi/10.1073/...

#PostdocRecruiting: My group at the University of Texas at Austin is recruiting a Postdoc in virology and structural biology. Please see more details here: utaustin.wd1.myworkdayjobs.com/UTstaff/job/... Informal inquiries are encouraged, and see more lab info here: zunlongke-lab.org

Our fourth installment on prefusion herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... Working with Ivelin Georgiev's group, we isolated and characterized prefusion-specific HSV gB antibodies from humans!

Our work on HIV-1 matrix, led by James Stacey and @dhrebik.bsky.social, is in this week's @nature.com. Extended explanatory video from @margotriggi.bsky.social. www.nature.com/articles/s41...