Added a little script to chimerax-trimmings to automate the creation of panels for model-map fit figures. It zones the map around (by default) 40aa parts of each chain (but doesn't cut in the middle of helices). Saves each as a png, metadata to csv. Saves each view as a scene for tweaking views.

Job navigation in table view, searchable tags, 3D mesh optimized for masks, and many more features! 👉👉👉 github.com/hanjinliu/hi... Let's make our RELION directory a better place.

We are incredibly excited to see our most recent story out @nature.com today:HIV triggers CD4-signaling to remodel nuclear pores and license infection!A heroic effort led by our very own @d-mesner.bsky.social & @mattvxwhelan.bsky.social! @blizardinstitute.bsky.social Link: tinyurl.com/HIVNup 1/11

It is finally out there in published form. 🎉 #MicroSplit (with an 𝕊) #Microscopy 🔬 #AI 🤖 www.nature.com/articles/s41... And no paywall... so... enjoy the read! 💸 👋 This is where the post could end... but I will have to go on for a bit below... 😉 🧵

Important announcement!!! 💫 Would you have a tooth pulled if it helped your chances to get an important grant funded? Absurd question, but the funding situation is so bad, that I bet some of you actually considered it for a second… keep your teeth! we created something that might help! 👇 (1/16)

Please like, retweet, and share with your favorite colleagues! Try q.e.d here! qedscience.com (you just drop a file and 10-15 minutes later it's ready) (16/16)

NEWS: The ERC Scientific Council has listened to the concerns from members of the research community about changes to the re-submission rules, intended to manage the surge in demand for grants. The Scientific Council will readjust some of the changes: link.europa.eu/TBqRQJ

New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...

New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment. So here's a 🧵. /1 www.science.org/doi/10.1126/...

NEW PRC PAPER 🚨: A comprehensive and timely review from @harsh3b.bsky.social and Amedee des Georges examines how deep learning is automating model building in Cryo-EM, streamlining structure determination and accelerating structural biology workflows. www.frontiersin.org/journals/mol...

People interested in the VPP aspects should also see a recent paper (from the people at Biohub) showing that tilt-series alignments can be improved with phase plate usage. journals.iucr.org/m/issues/202...

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold with crystallography and cryo-EM data. @moalquraishi.bsky.social www.nature.com/articles/s41...

ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...

Reviewers 5 months after the deadline when the editor sends urgent reminders to submit their reports

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD

DNA-PAINT with photocaged DNA labels = PhotoPAINT🔬. Why? No need for washing or mixing 👉🏻 higher accuracy in DNA-PAINT & other super-res methods. Fantastic collab with Alex Heckel & driven by the 'magic team' Nina Kaltenschnee and Marina Dietz 💪 doi.org/10.1002/anie... @goetheuni.bsky.social

Excited to share my first PhD project: LabConstrictor 📒🐍 Have you ever created a Jupyter notebook with all your love 🫶, only for others to be unable to install it 🥲? LabConstrictor, comes to solve this! Check out how it works in the preprint 🔗 arxiv.org/abs/2603.107... or follow this thread ⬇️

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

I've written a review on what I think is an extremely exciting direction in cryo-EM: Cryo-EM of endogenous membrane proteins in their native lipid bilayer Open access in Quarterly Reviews of Biophysics: doi.org/10.1017/S003...

🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process. www.biorxiv.org/content/10.6...

Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes www.science.org/doi/10.1126/... Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration! Linking below previous thread on our findings

A bit late to post, but check out this peer-reviewed version at PNAS 2025 here: www.pnas.org/doi/10.1073/...

2026 has been a remarkable year for me so far (despite the current world events): opening my lab at the University of Zurich, assembling an amazing group of people in the group, and celebrating it with a fantastic lab warming party. Figured it's also time for a small profile refresh.

It’s finally out! Together with @embopress.org and @reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).

Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...

#NatMicroPicks A microbial signature of health! 🦠⚕️ A large meta-analysis highlights the importance of previously unknown and uncultured gut bacteria in maintaining human health #MicroSky www.cell.com/cell-host-mi...

I'm very happy to see this nice discussion. The cytosol and crowding are a big deal in cell biology, but it's still not uncommon to see cells treated as though they were a bag of dilute, well-mixed molecules...

Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from Vietnam while celebrating the Tet holidays with family.

There was so much to unpack with this data, we teamed up with the marvellous @margotriggi.bsky.social to help explain what we think is going on. (Please also check out our model of central apparatus assembly here: www.biorxiv.org/content/10.6...)

Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells! Read our paper @cp-cell.bsky.social! ❕Publication: doi.org/10.1016/j.ce... ❕Press Release: www.biochem.mpg.de/en/pressroom @uoftmedicine.bsky.social @erc.europa.eu #UPSmeetMet

2026 has just begun and we are looking forward to welcoming you to EMBL for another year of groundbreaking science. Our programme now features even more events, check it out ➡️ s.embl.org/2026-poster

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...

🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬 Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing Apply here by 11 Feb www.nature.com/naturecareer...

We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...

This one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]

Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info. Deadline 8 Feb. Apply here: umustipendie.varbi.com/en/what:job/... #virus #virology #teamtomo #cryoEM

Check our new preprint smoothing rugged Cryo-EM landscapes: shorturl.at/gYs9U We tackle practical hurdles of Optimal Transport (OT) loss—differentiability, cost & noise sensitivity—make it a feasible inference workhorse. W/ G. Woollard, D. Herreros, @pilarcossio.bsky.social, K. Dao Duc 🧵👇 (1/9)

Online Now: Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii Online now:

A perfect Christmas gift from my parents. I can't wait to start reading the book. @matthewcobb.bsky.social

We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users. www.fz-juelich.de/de/karriere/...

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

A quick tutorial on the DAQ structure validation score for protein models derived from cryo-EM. DAQ evaluates amino acid–level accuracy in your model. Consider including a DAQ validation report in your next publication! www.youtube.com/watch?v=YRAT...

#cryoEM 🧪⚛️ Lena’s paper on imaging thick biological sections with STEM is finally published! We started this work almost 10 years ago. After Lena passed in 2023, I spent much of my sabbatical working with Yue and Steve to wrap this up. Also learned a lot about TEM vs STEM dose efficiency

We just released version v0.3.1 of 🍦Icecream! Importantly, this fixes a bug in missing wedge correction. Please update, and let us know how it works for you! #CryoET #TeamTomo github.com/swing-resear...

It’s been a while since I put together the Structural Virology starter pack, and I’m sure some new folks have joined Bluesky since then. There’s still plenty of space to fill, so if you’d like to be added to the list just let me know. #virology #cryoEM go.bsky.app/Qxv95BL

TomoCPT is a transformer-based solution that reformulates particle detection in cryo-ET as a centroid-prediction task using Gaussian labels #CryoET #ParticlePicking #SubTomogramAveraging doi.org/10.1107/S205...