Scientists are using tools and technologies like artificial intelligence to look for new medicines in plants and other natural products, advancing a centuries-old approach to drug discovery.

Grateful to @inquirer.com and Kela Yub for the feature on our lab's work. Using AI, we are unlocking the hidden therapeutic potential of nature, including in venoms, turning centuries-old drug discovery into approaches that reveal antibiotic candidates in minutes. Congrats to Xue Sherry Gao as well

Excited to speak today in beautiful Boulder at the Boulder Peptide Symposium on how AI is accelerating peptide design and discovery.

Back at @mit.edu , where much of our AI journey began teaching machines how to create new antibiotics. 🏙️✨ Thank you to the @mit.edu postdoc community for inviting me! As an MIT alum, this visit was especially special and meaningful.

Cesar de la Fuente has pioneered artificial intelligence approaches that have greatly accelerated antibiotic discovery, yielding numerous preclinical candidates that show promise for therapeutic intervention against currently untreatable infections. falling-walls.com/breaking-wal...

Diseñan con IA generativa antibióticos inéditos contra la resistencia bacteriana: www.agenciasinc.es/Noticias/Dis...

Fleming Prize Lecture and Interview with Professor César de la Fuente from Annual Conference 2025 is now available on YouTube. Watch their full interview and lecture: 'AI for Antibiotic Discovery' microb.io/4k8nChV #Microbio25

Tianang Leng, Fangping Wan, Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez: Predicting and generating antibiotics against future pathogens with ApexOracle https://arxiv.org/abs/2507.07862 https://arxiv.org/pdf/2507.07862 https://arxiv.org/html/2507.07862

🦠 "Common infections could once again become fatal." A new essay in Physical Review Letters by @delafuentelab.bsky.social & @aihealthmit.bsky.social faculty lead Jim Collins on how AI could transform antibiotic discovery. journals.aps.org/prl/abstract...

El grupo dirigido por el gallego César de la Fuente desarrolla una IA que diseña antibióticos nuevos #Galicia

El español César de la Fuente es uno de los científicos más destacados en la lucha contra las bacterias resistentes a antibióticos. Su equipo ha creado un modelo de IA que genera moléculas antimicrobianas desde cero, con eficacia comparable a fármacos aprobados. www.agenciasinc.es/Noticias/Dis...

🤖 A IA xenerativa AMP-Diffusion, creada polo equipo do galego César de la Fuente en Pensilvania, deseña antibióticos inéditos contra a resistencia bacteriana. 🧪 De 50.000 moléculas xeradas, dúas funcionaron tan ben como antibióticos actuais, sen efectos adversos.

(1/5)Excited to share our latest in @cp-cellbiomat.bsky.social @cellpress.bsky.social! We present a generative AI approach that designs novel antibiotics from scratch.

Last week, I presented @acs.org in a wonderful session on the future of peptide design to target infectious diseases. With superstar colleagues Terry Moore, Adrian Whitty, Gaurav Bhardwaj, Katerina Leftheris, Jane Aldrich, Elizabeth Rhee, and more!

Back from Dublin and #IMAP2025—grateful for the chance to share our lab’s work on peptide design and AI. Energized by the science and community. Until next time, Ireland. 🍀

La resistencia a los antibióticos es uno de los mayores desafíos de nuestro tiempo. Con ayuda de la IA, hemos identificado nuevos compuestos, llamados arqueasinas, con potencial antibiótico. ¡Gracias a @vozdegalicia.bsky.social por difundir nuestro trabajo!

La humanidad enfrenta grandes retos; la resistencia a los antibióticos es uno de los más urgentes. Con ayuda de la IA hemos descubierto potencial antimicrobiano en arqueas, ¡organismos del origen de la vida! Excelente cobertura de Raúl Limón en @elpais.com

Archaea are yielding a treasure trove of novel antibiotic molecules, thanks to AI. A significant step forward in the fight against drug-resistant bacteria. Pleased to see our work featured in @science.org!

I’m thrilled to be a Falling Walls Finalist 2025 (Engineering & Technology). Thank you Falling Walls Foundation for considering our work on Antibiotics AI falling-walls.com/foundation/p...

Grateful to @natbiotech.nature.com @natureportfolio.nature.com for highlighting our work. Using deep learning, we uncovered antibiotic molecules in archaea and showed anti-infective activity in mouse models.

Ante la amenaza global de las superbacterias, hallar nuevos antibióticos es crucial. 💡 En nuestro equipo usamos IA para acelerar su descubrimiento. Gracias Eugenio Mallol por la charla @forbes.com España👉

Research led by @delafuentelab.bsky.social found that species of archaea have evolved unique chemical defenses, which can kill #bacteria that make people sick & are antibiotic resistant. The #microbes may become a popular source for researchers. #antibioticresistance www.science.org/content/arti...

Join me at #ACSFall2025 — the global hub for cutting-edge chemistry! In this @acs.org clip, I share how AI moves us from dirt mining to data mining, discovering antibiotics fast enough to outpace drug-resistant bugs. The future of medicine starts now. 🎥 www.youtube.com/watch?v=bXWk...

Deep learning discovers antimicrobial peptides in archaea that show anti-infective activity in mouse models #NBThighlight www.nature.com/articles/s41...

(1/5)For over a century, the hunt for new antibiotics has focused almost exclusively on bacteria and fungi. Today, that paradigm shifts. By coupling state-of-the-art AI with the vast, largely uncharted diversity of Archaea, we open a new frontier for molecular discovery.

Great to see our research featured by @upenn.edu! 🐍🕷️ Using AI, we uncovered hundreds of potential antibiotics in snake and spider venom—opening new doors in the fight against superbugs. penntoday.upenn.edu/news/penn-de... @pennengineering.bsky.social @pennmedcso.bsky.social

Check out our piece in Nature Materials @natureportfolio.nature.com on Liu et al.'s deep-learning framework, TransSAFP. It identifies antimicrobial peptides with efficacy against biofilms and intestinal infections in mice—promising against multidrug-resistant bacteria and AMR.

What if venoms could fight superbugs? Our new study explores venom-derived molecules as antibiotics—highlighted by @natureportfolio.nature.com . 🚀 Huge thanks to the team!

Antimicrobial resistance is a rising cancer care crisis. Cancer patients face up to 3x higher rates of drug-resistant infections—especially as outpatients. Without effective antibiotics, safe cancer treatment is at risk. @upenn.edu @pennmedcso.bsky.social

Inspired by the high school students at @upenn.edu ’s Summer Biomedical Research Academy. Loved talking AI + antibiotics with the next generation of scientists. 🙌🧪🧠

🐍🕷️ Venom from snakes and spiders may help fight superbugs. In our new study, we show how venom-derived molecules can act as powerful antibiotics. Thanks to @pennmedicine.bsky.social for the great explainer!

Years ago, many doubted that AI could advance antibiotic discovery. It’s been a long journey, but the field has clearly entered a digital era of discovery. Check out our latest @physrevlett.bsky.social ‪ @apsphysics.bsky.social article with Jim Collins (MIT): journals.aps.org/prl/abstract...

AI is accelerating antibiotic discovery. Great teaming up with Jim Collins (MIT) and proud of our progress. Thank you @physrevlett.bsky.social for inviting us to cover this emerging field. Excited for what's next as we bring the antibiotics field into the digital age of discovery.

@upenn.edu researchers, led by @delafuentelab.bsky.social , used machine learning to uncover 100s of potential antibiotics from snake & spider venom. 80% showed antimicrobial power — some effective against drug-resistant bugs. 📄 Read in Nature: www.nature.com/articles/s41...

It was a great honor to receive the prestigious Fleming Prize. My lecture and a wide-ranging interview are now online; I hope they spark new ideas for the next generation of microbiologists. Grateful to ‪@microbiologysociety.org for sharing! www.youtube.com/watch?v=VRpH...

For years I have dreamt of a tool that could neutralize pathogens the moment they emerge. Today we unveil ApexOracle—an AI that, from a pathogen’s genome and phenotypic knowledge alone, predicts which antibiotics will work and invents new molecules for threats it has never seen.

A study in Nature Communications used AI to mine global venom proteomes and discovered novel peptides with antimicrobial activity. Several candidates showed efficacy against drug-resistant bacteria in laboratory and animal tests. go.nature.com/4f0zYb4 #medsky 🧪

ft. @megclarks, W. Mowel, @MFMich1, L. Joannas, J. Wright, I. Erickson, J. Henao-Mejia (@pennpathlabmed.bsky.social), L. Johnson, @andyjminn (@i3h-upenn.bsky.social), @rakez_krish, @delafuentelab.bsky.social (@PennPsych) & @ksimeono (@PennVet) @cp-immunity.bsky.social www.cell.com/immunity/abs...

I recently sat down with Drs. Quinn & Goldsmith to explore how intelligent systems are reshaping antibiotic discovery—freeing researchers from repetitive admin, and pointing toward a future of true “AI scientists.” We also confronted the harder questions: energy demand, server use...🎥

New paper in npj antimicrobials and resistance @natureportfolio.nature.com: a single course of meropenem leaves scars—mice stay in gut dysbiosis 30 days after clearing E. coli. A cautionary tale about the microbiome costs of antibiotics. 🦠 www.nature.com/articles/s44...

Computational exploration of global #venoms for #antimicrobial discovery with #Venomics #artificialintelligence pubmed.ncbi.nlm.nih.gov/40645962/ #MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech

🌟 During our #Biomolecular Interactions Modelling Course, @delafuentelab.bsky.social will give a talk on developing #Antibiotics using #AI.💡This innovative work is reshaping antibiotic development and could curb antibiotic resistance! 🗓️14Oct📍@i3suporto.bsky.social🔗bit.ly/3ZUSXNX @molbiom.bsky.social

A few weeks ago, I had the pleasure of visiting beautiful Siena to speak at the Palio Meeting, where we discussed the pressing issue of antimicrobial resistance. Grateful to Università degli Studi di Siena, #GSK, @nizet.bsky.social and all involved for the inspiring exchange.

(1/5) Venoms are a vast, largely untapped library of bioactive molecules—and our new paper in @natcomms.nature.com ‬ @natprot.nature.com reveals just how powerful they can be. 🐍⚡️

Excited to have participated in the 2025 Symposium on Generative AI in Molecule Discovery in beautiful Munich, along with amazing scientists and colleagues @machine.learning.bio, Francesca Grisoni, ‪@ewaszczurek.bsky.social‬‬, @fabiantheis.bsky.social and more... 🔬🤖 events.hifis.net/event/2015/

Las superbacterias son una amenaza real. En nuestro laboratorio buscamos nuevos antibióticos eficaces, ¡y las ranas🐸 nos han dado pistas sorprendentes! Hablé sobre ello en #agolpedebit de @radionacional.bsky.social ‬

(1/3) New in @ImmunityCP @CellPressNews: A single protein inside mitochondria, NDUFA4, keeps some immune cells in tumors “asleep.” Cutting its levels wakes them up, so they start attacking the cancer

Ever wondered how to mine for and generate new antimicrobial peptides from scratch? We show how to do it with AI in our latest piece in Accounts of Chemical Research @pubs.acs.org. Led by Paulina Szymczak, with @luispedrocoelho.bsky.social, Jun Wang, Ewa Szczurek and more!

Fantastic panel discussion with the great ‪Yana Bromberg‬, Ivelin Georgiev, and Theresa Koehler on the latest advances in #AI for antibiotic discovery and microbiology at @asm.org #ASMicrobe. Exciting times for science!

Had a great time speaking at the President’s Forum of #ASMicrobe in Los Angeles this weekend! Grateful to @asm.org for the invitation and the chance to share our Antibiotics AI work. Inspiring energy and conversations about where science can take us next.