🎥 Proud to share my @upenn.edu Penn Today video, “Uncovering New Antibiotics with AI.” See how AI is helping us find tomorrow’s antibiotics—today. Watch: penntoday.upenn.edu/news/uncover...

En mi charla de Frontiers in Genomics de UNAM MX exploro cómo la IA puede transformar el descubrimiento de antibióticos: de la minería de datos a la biología digital. 💡🔬 ¡No te la pierdas! 👉 www.youtube.com/watch?app=de...

Science runs on curiosity… and cookies. 🍪🧪 Thanks The Scientist for spotlighting our “Cookie Wednesday,” a sweet way to fuel cross-disciplinary creativity. www.the-scientist.com/scientists-s...

My friend #EltonBrand @sixersnba.bsky.social and I at my lab's Halloween party talking about the future of AI and Sports. What are your thoughts? Do you think #RudyFernandez and #SergeiIbaka would approve of our costumes?😉 Wishing everyone a Happy Halloween! 🎃

Big day at @upenn.edu ! Honored to host my friend Elton Brand from @sixersnba.bsky.social for a deep dive into how we’re using AI to fight antimicrobial resistance. Thanks for the sharp questions and team spirit, Elton! 🧪🏀

It was an honor to participate in the third course organized by @mobilise.bsky.social @i3suporto.bsky.social, sharing experiences with incredible people. A privilege to learn, share, and connect with such an amazing group.

Check out our @natbiotech.nature.com @natureportfolio.nature.com piece with Yumeng Zhang + Jiangning Song on @genentech.bsky.social's deep learning approach to accelerate antibiotic discovery. Congrats to Gabriele Scalia, Tommaso Biancalani, Man-Wah Tan, Aviv Regev, @yoshuabengio.bsky.social et al!

Feed: "Nature Biotechnology" By: Tommaso Biancalani

Deep learning reveals antibiotics in the archaeal proteome 🏺🧪 Marcelo D. T. Torres, Cesar de la Fuente-Nunez @delafuentelab.bsky.social et al www.nature.com/articles/s41... Findings highlight the potential of archaea as a resource for developing next-generation antibiotics.

Feed: "Nature Biotechnology" By: Cesar de la Fuente-Nunez

Penn's César de la Fuente joined Science Friday to discuss how his lab is using #AI to uncover new antibiotics hidden in ancient microorganisms—potentially offering new solutions to the global antibiotic resistance crisis. 🎧 Listen: https://www.sciencefriday.com/segments/nobel-prize-archaea/

1/5 Today we are introducing the Key-Cutting Machine (KCM) for protein and peptide design. Like cutting a key to fit a lock, KCM sculpts sequences to match a target backbone—on a single GPU. No retraining. No clusters. 🧬🔑

La ULE propone el Honoris Causa al científico César de la Fuente y al ingeniero Sergio Boixo - www.heraldodeleon.es/articulo/uni...

Grateful to @scifri.bsky.social for inviting me to share our latest work using AI to identify new antibiotics in archaea by digitally mining its genetic code. Huge thanks to @heyira.bsky.social for a wonderful conversation!

🧬 Today we introduce Key-Cutting Machine (KCM)—an AI tool that designs proteins like cutting a key to fit a lock. Runs on 1 GPU. No retraining. No clusters. Precise, accessible, and tested in vivo. Now in @natmachintell.nature.com 🧠🔑 @natureportfolio.nature.com www.nature.com/articles/s42...

Thrilled to be part of this paper in npjAMR @natureportfolio with William J. Waldock, Hannah Thould, Leonid Chindelevitch, Nicholas J. Croucher, James J. Collins, Hutan Ashrafian & Ara Darzi! We tackle AMR globally and explore AI-driven solutions. www.nature.com/articles/s44...

Antibiotic resistance kills millions, but @delafuentelab.bsky.social's lab is fighting back. By pairing AI with human insight, researchers are uncovering hidden antimicrobial peptides across the tree of life with a 93% success rate against deadly pathogens. ow.ly/u1Nl50XcRJW

AI could reshape infectious disease control end-to-end—from faster outbreak detection to smarter diagnostics—but progress is constrained by data. My @thelancetinfdis.bsky.social @thelancet.com article lays out how to break the bottleneck responsibly. www.thelancet.com/journals/lan...

Thank you so much for having me. It was wonderful to be back @i3suporto.bsky.social in beautiful Porto—my first time since childhood. Fantastic friends and science all around!

🎥 @delafuentelab.bsky.social Uncovering new #antibiotics with #AI | Penn Today penntoday.upenn.edu/news/uncover... #MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech

Thank you so much for highlighting our latest work!

Research Highlight: Mining archaea for antibiotics www.nature.com/articles/s41...

En España mueren más de 4.000 personas al año por infecciones resistentes a los antibióticos. Urge innovar, sensibilizar y actuar. Gracias COPE por difundir nuestras últimas investigaciones. 🎙️🔬 www.cope.es/programas/he...

(1/2) AI is redefining antibiotic discovery. What once took years with traditional methods can now be done in hours.

El equipo del gallego César de la Fuente presenta una plataforma de IA que diseña antibióticos nuevos #Galicia

Excited to highlight our News & Views on the article by Torres et al. from @delafuentelab.bsky.social team 🚀 Archaea could help to discover new antibiotics! Read it here: www.nature.com/articles/s41...

Deep-mining the archaeal proteome for antibiotics News & Views by Rafael Laso-Pérez @gecko1990.bsky.social @delafuentelab.bsky.social Read it here: rdcu.be/eHNwa

Deep-mining the archaeal proteome for antibiotics www.nature.com/articles/s41...

(1/9)For over a century, antibiotics were found by slow, painstaking, serendipitous screening. Today we share a different path: the first demonstration of deep reinforcement learning (RL) for antibiotic discovery.

Over 200 leaders — including 10 Nobel laureates & top AI experts — call for AI red lines to prevent dangerous uses. I’ve signed the Global Call for AI Red Lines for responsible use of AI: red-lines.ai

Scientists are using tools and technologies like artificial intelligence to look for new medicines in plants and other natural products, advancing a centuries-old approach to drug discovery.

Grateful to @inquirer.com and Kela Yub for the feature on our lab's work. Using AI, we are unlocking the hidden therapeutic potential of nature, including in venoms, turning centuries-old drug discovery into approaches that reveal antibiotic candidates in minutes. Congrats to Xue Sherry Gao as well

Excited to speak today in beautiful Boulder at the Boulder Peptide Symposium on how AI is accelerating peptide design and discovery.

Back at @mit.edu , where much of our AI journey began teaching machines how to create new antibiotics. 🏙️✨ Thank you to the @mit.edu postdoc community for inviting me! As an MIT alum, this visit was especially special and meaningful.

Cesar de la Fuente has pioneered artificial intelligence approaches that have greatly accelerated antibiotic discovery, yielding numerous preclinical candidates that show promise for therapeutic intervention against currently untreatable infections. falling-walls.com/breaking-wal...

Diseñan con IA generativa antibióticos inéditos contra la resistencia bacteriana: www.agenciasinc.es/Noticias/Dis...

Fleming Prize Lecture and Interview with Professor César de la Fuente from Annual Conference 2025 is now available on YouTube. Watch their full interview and lecture: 'AI for Antibiotic Discovery' microb.io/4k8nChV #Microbio25

Tianang Leng, Fangping Wan, Marcelo Der Torossian Torres, Cesar de la Fuente-Nunez: Predicting and generating antibiotics against future pathogens with ApexOracle https://arxiv.org/abs/2507.07862 https://arxiv.org/pdf/2507.07862 https://arxiv.org/html/2507.07862

🦠 "Common infections could once again become fatal." A new essay in Physical Review Letters by @delafuentelab.bsky.social & @aihealthmit.bsky.social faculty lead Jim Collins on how AI could transform antibiotic discovery. journals.aps.org/prl/abstract...

El grupo dirigido por el gallego César de la Fuente desarrolla una IA que diseña antibióticos nuevos #Galicia

El español César de la Fuente es uno de los científicos más destacados en la lucha contra las bacterias resistentes a antibióticos. Su equipo ha creado un modelo de IA que genera moléculas antimicrobianas desde cero, con eficacia comparable a fármacos aprobados. www.agenciasinc.es/Noticias/Dis...

🤖 A IA xenerativa AMP-Diffusion, creada polo equipo do galego César de la Fuente en Pensilvania, deseña antibióticos inéditos contra a resistencia bacteriana. 🧪 De 50.000 moléculas xeradas, dúas funcionaron tan ben como antibióticos actuais, sen efectos adversos.

(1/5)Excited to share our latest in @cp-cellbiomat.bsky.social @cellpress.bsky.social! We present a generative AI approach that designs novel antibiotics from scratch.

Last week, I presented @acs.org in a wonderful session on the future of peptide design to target infectious diseases. With superstar colleagues Terry Moore, Adrian Whitty, Gaurav Bhardwaj, Katerina Leftheris, Jane Aldrich, Elizabeth Rhee, and more!

Back from Dublin and #IMAP2025—grateful for the chance to share our lab’s work on peptide design and AI. Energized by the science and community. Until next time, Ireland. 🍀

La resistencia a los antibióticos es uno de los mayores desafíos de nuestro tiempo. Con ayuda de la IA, hemos identificado nuevos compuestos, llamados arqueasinas, con potencial antibiótico. ¡Gracias a @vozdegalicia.bsky.social por difundir nuestro trabajo!

La humanidad enfrenta grandes retos; la resistencia a los antibióticos es uno de los más urgentes. Con ayuda de la IA hemos descubierto potencial antimicrobiano en arqueas, ¡organismos del origen de la vida! Excelente cobertura de Raúl Limón en @elpais.com

Archaea are yielding a treasure trove of novel antibiotic molecules, thanks to AI. A significant step forward in the fight against drug-resistant bacteria. Pleased to see our work featured in @science.org!

I’m thrilled to be a Falling Walls Finalist 2025 (Engineering & Technology). Thank you Falling Walls Foundation for considering our work on Antibiotics AI falling-walls.com/foundation/p...

Grateful to @natbiotech.nature.com @natureportfolio.nature.com for highlighting our work. Using deep learning, we uncovered antibiotic molecules in archaea and showed anti-infective activity in mouse models.