Extremely proud that our competition on AMP generative AI design will be a part of @neuripsconf.bsky.social 2026! It's going to be a blast 💥 with @ewaszczurek.bsky.social , @delafuentelab.bsky.social , at @helmholtzmunich.bsky.social, @upenn.edu 🙂 szczurek-lab.github.io/amp-challeng...

🧵 1/ Announcing AMP Challenge! AMR is one of the biggest challenges in medicine, and antimicrobial peptides (AMPs) are a promising way to fight back. If you build AI models for biological sequences, AMP Challenge gives you a test: selected peptides will be synthesized and tested for free. 🧬🚀

If I have to explain to you why it's a bad idea to use a machine that makes shit up 15-80% of the time AND destroys the environment AND contributes to rising fascism and genocide AND puts brilliant skillful creatives out of work by stealing their work, then we're already speaking different languages

Final call to join us the Munich Symposium on Generative AI in Molecule Discovery, for a day full of insights and networking opportunities, at our brand-new ✨ Conference Center @www.helmholtz-munich.de Check our agenda and secured your spot before June 24: events.hifis.net/event/2015/

Last days to register! Come and join us at the Symposium!

"Life is the shape it is for a purpose And when you see how things really are all the hurt and the waste falls away. What's left is the beauty" Rosalind Franklin, in the "Life Story" movie (1987), especially recommended watching for early career scientists. vimeo.com/179934156?&l...

Dark academia: spending a lot of time in the microscopy room as a grad student

Save the date for the Helmholtz Munich AI for Health Symposium 2025, devoted to the topic of Generative AI in Molecule Discovery! July 4, 2025 Helmholtz Munich Campus in Neuherberg, Germany What now? Register and submit abstracts (deadline May 2, 2025!) events.hifis.net/event/2015/r...

Use reward-guided generation and iterative refinement to steer the proteins generated from EvoDiff! arxiv.org/abs/2502.14944

Programming languages named after people: Ada, after Ada Lovelace Haskell, after Haskell Curry Bourne and Korn shells, after their inventors Pike, after Rob Pike Wolfram, after Stephen Wolfram Julia, after no one in particular Erlang, after Agner Erlang Pascal, after Pedro Pascal

Hearing from Community Partners International, which works from Myanmar to Bangladesh, that USAID cuts mean 14,000 people with HIV losing access to lifesaving meds and a total stop in all HIV and TB screening. So many people will die due to these chaotic, sudden, horrifically implemented cuts.

Here I react to the shameful encounter between American leaders and media and the Ukrainian president. No doubt there were more, but I saw five failures on our side: of hospitality, decency, democracy, strategy, and independence. Please watch and share. snyder.substack.com/p/five-failu...

All probationary federal employees at NOAA’s EMC that’s responsible for keeping all US weather model systems running have been fired with 1 hours notice. And that includes me and colleagues. We will not go quietly because we care about the NOAA mission to protect the public.

Per Dr Atul Gawande, ex USAID: “All malaria supplies protecting 53 million people, mostly children, including bed nets, diagnostics, preventive drugs, and treatments – terminated.” There are no words that sufficiently describe this level of cruelty and sadism.

At the Antimicrobial peptides GRC Conference in beautiful Ventura, California. Thanks to Delphine Destoumieux-Garzón and Gerard Wood for the invitation and the opportunity to talk about Generative AI for antimicrobial peptide discovery! With @szymczakpau.bsky.social, her poster and amazing sunset:)

Good to see moscot-tools.org published in @nature.com ! We made existing Optimal Transport (OT) applications in single-cell genomics scalable and multimodal, added a novel spatiotemporal trajectory inference method and found exciting new biology in the pancreas! tinyurl.com/33zuwsep

1/🧬 Excited to share PLAID, our new approach for co-generating sequence and all-atom protein structures by sampling from the latent space of ESMFold. This requires only sequences during training, which unlocks more data and annotations: bit.ly/plaid-proteins 🧵

Next up - contributed talk. HelixFlow, SE(3)–equivariant Full-atom Design of Peptides With Flow-matching Models Xuezhi Xie, Pedro A Valiente, Jisun Kim, Jin Sub Lee, Philip Kim

Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...

Hi @ddelalamo.bsky.social unfortunately, this paper from Jain et al. contains falsehoods, misleading comparisons, seemingly deliberate omissions, and is written in a tone not intended as a serious research paper. Please see our detailed response: www.linkedin.com/pulse/respon...

Looks like yet another case of overhyped results due to poor #bioMLeval evaluation of deep learning models -this time deep docking methods - specifically DiffDock. Look forward to the DiffDock authors response. But dont see any major flaws in this critique. Conclusion is REALLY worth reading!

Oh wow. Maybe kind of a harsh attack, but we really do need a healthy debate about docking benchmarks. While I'm excited to see this one being fought out, may I already suggest the next point of debate: can we find a better metric than the utterly inadequate 2 Å RMSD cutoff?

scRNA-seq has revolutionized biology, but it’s not without challenges. We uncovered significant quality issues in widely used reference cell atlases like the Human Cell Atlas and Tabula Sapiens. Up to 85% of cells in some datasets are low-quality or misidentified! 2/8

Excited to share our study led by @SakenovaNazgul! We used chemical genetics to identify and understand cross-resistance & collateral-sensitivity (CS) between antibiotics and reduced AMR development with CS drug pairs @embl.org with @camille_goemans @EPFL_en www.nature.com/articles/s41...

I have created a starter pack for the Polish ML community. Let's grow it together! Let me know if you know somebody who should be included. go.bsky.app/TSkgFjK

Nauka na okładce! Polecam jeszcze raz świetny tekst @alicjagardulska.bsky.social, którego nie sposób przeoczyć w weekendowej Wyborczej 🙂

Online Now! A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden by Olivia N. Rebeck, Miranda J. Wallace, Jerome Prusa, Gautam Dantas, et al at @WUSTL @MDAndersonNews http://dlvr.it/TGPvW1

Meet the biotech startups brewing milk in bioreactors to improve on baby formula

Trying to build a #proudofalumni list here on BlueSky. Here is a start, if others are here please reply so I can add you... @jeremybaskin.bsky.social @glycocode.bsky.social @nmriley.bsky.social @jcstark.bsky.social @raflynn5.bsky.social @pengwu.bsky.social ....

Hey @biorxivpreprint.bsky.social, I think you need to add another icon here 🦋

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

This diagram was made by Christine Liu, PhD - creator of two photon art @christineliuart.bsky.social I think you’ll love it :) @odedrechavi.bsky.social

🚨IIMCB in Warsaw is hiring a Junior Group Leader in Computational Biology!🚨 We’re looking for early-career researchers ready to establish their own independent groups! iimcb.gov.pl/en/job-offer... #ComputationalBiology #ScienceJobs #Bioinformatics #RNAResearch

Why do insects fly around artificial lights? They don't actually want to fly towards them, they just can't really get away from them. Insects naturally tilt their dorsum towards a light source, and as a result end up flying around it in circles, trapped. 🧪 🦋 www.nature.com/articles/s41...

#FluorescenceFriday has been epic! Thanks for sharing! I’ll put up a very boring characterisation of a transgenic line. Sagittal spinal section showing GC6 expression (green), inhibitory (blue/magenta)and excitatory neurons (red only)

As a social scientist working on antibiotic resistance, I continue to learn about the biomedical science and clinical aspects of the problem. This #WAAW, I thought I’d share some facts that surprised me. A 🧵

Scientific tattoos 😍✒️

The 1st rule of day science is to ask for each result, what is the negative control and what is the positive control, because we forget how easy it is to fool ourselves.

To save you time, I have distilled this down to the one (probably only) sentence that will be cited ad nauseum (until the next update of course). www.thelancet.com/journals/lan... #AMR #IDSky #MicroSky

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

The Night Science Podcast is now on Bluesky! bsky.app/profile/nigh... Here's a starter pack to connect with some of our previous guests! go.bsky.app/Q5vFUQk

Four more days to apply to be a PhD intern in the BioML group at MSR! jobs.careers.microsoft.com/global/en/jo...

I have been talking about it for ages - and now it is finally out *Orthrus: an AI-powered, cloud-ready, and open-source hybrid approach for metaproteomics* www.biorxiv.org/content/10.1...

Looking for #AMP and #AMR people!