Astrocytes make up one-quarter of the brain. Nature reports how researchers are learning their value in shaping our behaviour, memory, and health. #Neuroskyence 🧪

Excited to share that our new preprint is out, showing PV function linked to glial states by DNMT1. "DNMT1 Coordinates PV Interneuron–Glia Coupling to Maintain Cortical Network Stability and Regulate Behavior." www.biorxiv.org/content/10.1...

Nice review on lncRNAs in the brain by John Mattick and colleagues. doi.org/10.1038/s415...

We’re hiring! @RWTH is opening a W3 Full Professor position in Stress Resilience of Plants 🌿 Join a strong research environment with excellent facilities & great colleagues in the Faculty of Maths & Natural Sciences. Please share & spread the word! www.rwth-aachen.de/go/id/crfe/?...

Small primate shows big promise? Grey mouse lemur exhibits various age-related changes in microglia. #neuroscience preLighter Isabel Paine covers a recent #preprint from Léo Dupuis and colleagues #CEA_Jacob_ #preLight ⬇️👀 prelights.biologists.com/highlights/n...

Honored to see our work featured among the Editors’ Highlights in the “From brain to behaviour” collection at @NatureComms! 🧩 DNMT1-mediated regulation of somatostatin-positive interneuron migration impacts cortical architecture and function ➡️ www.nature.com/ncomms/edito...

Nature’s 2025 PhD survey asked doctoral candidates worldwide what advice they would give to someone considering a similar degree. Respondents gave advice on choosing supervisors, managing mental health, and surviving academic culture. #Academicsky 🧪

The NIH institute director firing last Friday is very bad. I made a video explainer about why. Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social 1/4 🧪

The authors of a Comment article discuss how scientists, research institutions, funders, libraries and publishers must all improve software practices. They outline recommendations for an approach to handle software better. #Academicsky 🧪

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Pipeline Olympics for DNA methylation data Check this out: doi.org/10.1093/nar/... Important study from @rn-toth.bsky.social & @pavlolutsik.bsky.social Published @narjournal.bsky.social #epigenetics #methylation #bioinformatics

Tests of large language models reveal that they can behave in deceptive and potentially harmful ways. Nature reports on what these results mean for the future of AI. 🧪

What if the DNA methylation enzyme DNMT1 isn’t just about DNA? Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking. A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...

Hell yes, Pittsburgh. Love Yinz. No Kings.

Portland Oregon: #NoKings one of the most anticipated protests does not disappoint!

🚀 The RWTH Center for Computational Life Sciences (CCLS) brings together AI, modeling & biology to decode life’s complexity. Explore how data-driven research is shaping the future of health & sustainability Watch the video 👉https://youtu.be/uZ9oFc8E4Us?si=VwDm5hfrWO6eUNMC

Today: Seminar on: Addressing Neurodegenerative Diseases in Support of SDG 3: Good Health and Wellbeing: Recent Advances in Alzheimer’s and Other Neurodegeneration Research cassyni.com/events/QuBDF...

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events. Deafening Quiet from the Scientific Establishment jeremymberg.github.io/jeremyberg.g... 1/14

🚨 NRW Return Programme 2026: Up to €1.25M over 5 years to establish your own independent research group in the Life Sciences (e.g. neurobiology). 👉 More details: www.mkw.nrw/themen/wisse... A great opportunity – also here in Aachen! 🌍🧬

Several scientists have received letters from the NIH director disinviting them from their positions on advisory councils that make final decisions on grant funding, I'm told. In July, I reported that NIH staff were told to select members aligned with Trump administration priorities.

Since their discovery in 2004, the grid cells in the brain have been regarded as a kind of "GPS in the head." However, scientists at DKFZ and Heidelberg University Hospital have now shown that grid cells work much more flexibly than previously assumed. @nature.com Neuroscience t1p.de/hpj1m

“Many scholars from historically overexploited countries (often referred to as the global south) expected that exposing the problem would trigger change. Four years on, I see it clearly: the scientific system was never designed for equity,” writes Dolors Armenteras in Nature. #Academicsky 🧪

The deadline is approaching! Check out that great opportunity!

Open Call @embl 📍 Heidelberg 🧬 Postdoc position (3 yrs) – Computational Biology Join a world-leading research environment & drive cutting-edge data-driven biology! 🔗 Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/d... #ComputationalBiology #EMBL

And now for an update on my office window. www.thecrimson.com/article/2025...

🌍 Open Call! RWTH Aachen University invites postdocs from outside the EU to apply for the “Port to Europe” Fellowship (24 months funding, all disciplines). Start your research journey at one of Europe’s top universities! 🚀 Deadline: Oct 5, 2025. 👉https://rwth-aachen.de/go/id/botjje/lidx/1

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

Excited to share the story behind our recent Nature Communications paper: 👉 “Epigenetics in motion: How DNMT1 steers interneuron migration and identity”, communities.springernature.com/posts/epigen...; #NatureCommunications

Check out this paper by Werner Dykstra in which we study the effects of GFAP mutations on brain organoid development. doi.org/10.1002/glia...

Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!

🧠 Our new study is out in Nature Communications! We show that DNMT1 regulates the migration of postmitotic cortical interneurons, with implications for cortical layering and function, and potentially disease conditions. 🔗 doi.org/10.1038/s414... Huge thanks to the amazing team/collaborators!

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵 biorxiv.org/content/earl...

The authors of a Comment article in Nature “urge STEMM scientists in the United States to avoid the mistakes of the past and instead stand together and fight for both personal and academic freedom.” #Academicsky 🧪

Here is the collective effort of 12 labs, lead by my own at the Broad to target the range of cortical interneuron subtypes! These tools should be a game changer for all of you using NHP and other less genetically amenable species! Have at it! urldefense.proofpoint.com/v2/url?u=htt...

Cherry blossoms in full bloom—nature’s quiet reminder that beauty persists, even when the world feels heavy. A moment to pause, breathe, and take in the light…

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze! www.biorxiv.org/content/10.1...

if any of you want to understand the depth of the attacks against american universities by the current administration and their ultimate goal, you have to watch this 👇 In my opinion, necessary to grasp the magnitude of the disaster we are facing: youtu.be/0FR65Cifnhw?...

Science is an investment that pays enormous dividends. So if you’re business-minded, it’s an offer you can’t refuse! Here's my full speech from the Stand Up For Science rally in DC today: www.youtube.com/watch?v=eemj...

Honored to be part of this exciting work published in Science Advances! 🎉 Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function - Grateful to the fantastic team behind this!👏 🔗 Read more: www.science.org/doi/10.1126/...

More hits to #NIH: "The Trump administration has imposed a new restriction on employment that could push out thousands of NIH’s senior scientists: The agency cannot retain scientists in 1-year to 4-year positions that have long been routinely renewed." 🧪 @jocelynkaiser.bsky.social at @science.org

xkcd.com/3056 #RNAsky

The Society for Developmental Biology has released a statement on the Unprecedented Disruptions to Biomedical Research in the United States.

Call to End Freeze on Federal Grants The White House's pause on federal grants threatens our nation’s scientific progress. Read SfN's full statement urging this Administration to lift the freeze to protect the health and security of our nation: bit.ly/4gq9i2I

Many of you may not be familiar with #NIH grants. Here are some facts to help you understand the magnitude of this disaster. 1) NIH grants are extremely difficult to get & not "free money". Researchers must have preliminary data & write detailed proposals. Mine was >200pages & took years to put

📢 We are recruiting group leaders! We seek researchers who address fundamental questions in biology, including the development, the function, and the dynamics of complex biological systems. APPLY before March 30th 2025 👉 www.ibdm.univ-amu.fr/we-are-recru... #ScienceCareers #Marseille

"As of today, it looks as though Donald Trump is in the process of freezing federally-funded cancer research in the United States," says @chrislhayes.bsky.social