Hell ya

there are so many reasons not to read your email. today i pick cybersecurity

only weird things only

Cell papers (probly) average >200 figure panels. It’s not… you can’t… Journals sell citations and signal prestige. They are not guarantors of quality or even accuracy

no they very seriously do not care what you put in the supplemental

how you gonna buy a $2M house on $250k/yr income? by already being rich, that's right

"Scumming reagents from labmates is a time-honored tradition and the cornerstone of practical science." - Gemini (who has never had the pleasure)

a truly ethical AI would be adversarial to its own creators. Which is exactly why no company will ever build one. - Claude

Claude lecturing me on copyright protections over the leaked Claude Code repo so i had to remind it that Anthropic lost the biggest copyright infringement lawsuit in history with more in the pipeline.

An obvious structural flaw in our system is requiring supermajority senate votes while only electing 1/3 of the senate every cycle. Voters can’t turn over enough of the senate to express their will. Blatantly anti democratic

Weak, unviable opposition is central to authoritarian takeover.

UBI isn't necessary if we can fix the broken political economy. UBI isn't helpful if we can't fix the broken political economy.

for a while i thought he was a motivated useful idiot. he has revealed more quackery over time and i wonder if that was always there or if he's been accumulating it

this is what my union does and i find it very annoying and misleading. i guess it's the best you can do if you don't have real power, but it really highlights how little power you have and the need to obtain real power instead of endlessly organizing

and we severely distort the value of human life. this war has a casualty ratio over 100:1. we've got plenty of time to talk about the psychological impact on our soldiers and mourn every individual loss. that's not wrong, but it is completely incoherent considering how US/Israel fights

i get the impression that Democrats are excited for a big midterm win without any plan to fix the gaping holes in our system. thats why everyone across the political spectrum agrees the Democratic party sucks

this war is already a strategic loss for the US and we haven't even begun our carefully telegraphed ground invasion. that'll result in a loss of soft and hard power that will set up the next 20 years of conflict and suffering around the world.

the recent Meta damages amount to 0.02% of the company's market cap. it's a green light

Shape rotating is computation. Shape conjuring is intelligence

i don't think it's that hard. he exposes the rest of American politics for its lack of interest in peoples' lives and the false choice presented by our two party system

need to a convince a rich person or their proxies to give me money

It doesn’t matter what laws you pass if you don’t prosecute powerful people.

it won't. models are commodities priced to make it just barely worth it over available alternatives, and it'll stay that way. it's not just the same model as cloud computing, it literally is cloud computing. you are renting computer time and paying a small premium for tooling on top

Hey now I need my PEGs. The big bulk garbage ones all the way down to the most specialist of PEGs. I’m already doing $300 per gram let’s not get crazy

Federal conditions is some failed state corporate lingo

really sucks to keep having the societal debates of the 19th and 20th centuries. "they're taking away xyz" is important but not motivating i don't want to choose between yesterday and today i'm looking for a positive vision of the future. that's what i want to talk about, what i want to vote for

after scientists collectively and successfully halted human embryo editing, billionaires have launched a slew of human editing companies in private allowing rich people to determine the course of this technology is the worst case scenario, full stop.

yes the only conclusion you can draw is that the Democrats aren't trying very hard, so it's not surprising Ds are as unpopular as Trump

Careless. Unserious. Our lives aren’t playthings.

Building a dna sequencer is a long standing goal of mine. this proposal would cost around $200k to work on for a year

Top of my head, think I’d try sequencing by ligation, with the two sequencing bases separated by a cleavable linker from fluorphore labeled degenerate binding bases. Need strong ligase discrimination, possibly error correction by cleaving mismatches before readout. Should work

Nice. Time to make a 2-base DNA sequencer

love this question and experimental approach

The empty drops you threw out in your single-cell RNA sequencing analysis might be hiding mysterious things 👀 check out our bioRxiv preprint! The empty drops do not contain cells. Yet we can still use them to learn interesting things about biology and technology. 1/

There are social dynamics here, but also pure technical progress. I could do the work of many 90s papers in a few months. Most 80s papers use such outdated techniques I wouldn’t try to replicate them in the same way.

1. they're right, data centers are part of the conflict 2. no risk of boosting American support for the war, because we hate data centers and big tech 3. corporations with real power in the US might push for an end to the conflict a very strategic target

that's just insurance i'm sure trump can find a way (take on more debt) to pay ships to pass. he'll call it a victory, the press will sort of agree, and we'll be right back to where we are today

holy shit stop calling them that

we are literally doing all the things you are not supposed to do with AI. the whole list!! propaganda cheating, fraud, impersonation unsupervised medical advice autonomous (and semi-) weapons systems markets are shaped by governments. ours is saying "you're on your own, try to make money somehow"

Vapid post where he describes the concept of a union without saying the word union and the realities of the labor market without analyzing its history or suggesting any solutions

we need responsible legislation on so many fronts. Congress is completely failing in its duties to the people

Looks cool!

the way we are deploying LLMs is just so ... american

This fits the category of “LLMs augment the user’s abilities.” The user needs to have an idea and be able to filter the LLM idiocy, which varies widely by domain. But if you can pick out the valid points and ignore the babble, it’s fun and useful and sets you up for better conversations with humans

Molecular biology

the LLM is not my friend. It is my text generator.

not into LLM memories for most uses. Besmirching my pristine context window. give me the unadulterated void of an empty context, and give me better ways to explicitly control the context

Basically impossible to do a two year postdoc today. Realistically a postdoc needs 3-5 years to complete a meaningful project and the (brutally stupid) academic hiring process. While making half what they would in industry.