Egypt look really good! playing great at all levels

screw that bring back media regulations, campaign finance law, proportional representation, and education

This man: Did not play Got a yellow card anyway Broke his wrist Left behind in CDMX tough night

on one hand, nobody got less juice than post-Brexit UK. on the other, they are suckers for intentionally embarrassing themselves

Belgium, stop with the official channels you gotta play to your strengths: a suitcase full of diamonds, a life-size chocolate De Bruyne statue, and enough beer to drown Zurich there is still time

we have massive amounts of unused retail and office space in the most desirable locations. a future city should be super dense and almost entirely devoted to residential + leisure/entertainment/gathering space. and close the streets we don't need em

Belgium is not nearly wealthy enough to win a ruling in these United States

trump was planning big corrupt pardons to celebrate our nation's 250th, but even he didn't see this one coming. he's all too happy to step in. it is literally his pleasure

look the rules clearly state that FIFA can change the rules at any time for any reason and if they aren't changing the rules for you, maybe you should find a President who loves football as much as Donald J. Trump

bunged this into Claude and it cites the incredibly intensive duck farming in exactly these counties and the known routes of H5N1 transmission. so the Amish poop-water story doesn't really fit, but there is an equally interesting industrial farming explanation

ah shit now the whole world knows, too?

what i find most interesting about this work is that it was performed in Minnesota. Europe has been very forward looking with their Synthetic Cell Initiative, and a lot of the best synthetic life work is European

hyping your paper to get it published in Nature, and then getting rejected, is the journey of almost all papers submitted to Nature. it is not a commentary on preprints or the paper (which i have not yet peer reviewed), but on the journal system and the credit assignment problem

Met a friend in San Jose for the game. Whole city is out for Mexico. Viva!

$600 with BAM, FASTQ, and VCF this is the service I’ve been looking for for years. just wanna check their data privacy policies

I’m not gonna elevate email to the level of artistic expression.

attacks on science are an attack on objective reality itself. objective reality is the most legitimate check on unlimited power, so its advocates must be defeated

unitary executive theory is a consequence of the Electoral College, two-party system, and thermostatic voting. you will hold the executive about half the time, by design, so the obvious thing to do is grant the executive sweeping power when you are in office and delegitimize it when you're not

A major pillar of the system is paying its skilled employees below-market “subsistence stipends” and sharing their work for free. private industry knows it’s the biggest beneficiary. It doesn’t want the music to stop

Has he tried asking Alexander Wong

0/10 food texture for me

these are insane choices. he picked two of the most successful examples of the explicit government-academic-industry drug development system and claimed them for private industry

Balogun red card totally sucks. changes this game completely AND he's out for the next game, one of the most exciting players for the US. the red was harsh

in grad school i really wanted to do a comparative sc-RNA-seq study looking at transcription in multiple tentacles within and across individuals in the Giant Green Anemone

here's the thing to watch for: massive buildout of physical laboratories and clinical trials. this is what Dario himself called for in Machines of Loving Grace. until they start building labs, huge labs, it's all talk

this is going to sound sooo hypey but i can't wait for biodiversity pangenomes and pantranscriptomes

1100 structures?! Oh, chemist, ok. Still quite a lot!

Quite a discount they do a trillion a year in revenue and 50% CAGR

the problem is less that a democratic trifecta is required to pass certain legislation and more that a democratic trifecta would choose not to pursue that legislation once in office. paradoxically (or, pathologically?), this reduces the will of voters to elect a democratic trifecta

Nuclear Bluesky discourse is that alt text is perfect LLM training data.

I think this is going to be a major point of future litigation as the displacing effect of LLMs directly undermines the incentive for creative work that copyright is meant to protect

wow this looks really cool. Gonna need to go through the evidence to see how strong their case is

LSRs are like molecular mousetraps! they aren't true catalysts because they violate microscopic reversibility. they don't accelerate the forward and reverse reactions. instead, they use protein conformational changes to drive the substrate from reactant to product state 1/2

really great paper from Sangamo, now peer-reviewed over two years after the initial preprint! this paper used LI Integrase and a RoseTTAFold model of Bxb1. since the preprint, structures of Bxb1, PhiC31, and SP-beta LSRs have all been solved. tons of great work in the LSR field recently

ironically China's model is likely not optimal. if lab heads feel money is abundant, China should build more labs. it's a sign that there are under-utilized researchers and you won't learn that by interviewing the successful PIs the right balance is competitive but not suffocating

Most journals and funders forbid running others' unpublished work through AI tools — uploading a manuscript or grant you're reviewing is a confidentiality breach. Using AI on your own unpublished work is usually fine with disclosure, but can itself be a disclosure that jeopardizes confidentiality.

scientists should not drop their standards for rigor when they support the conclusions being drawn

this lane (do popular things that improve peoples' lives) has been open for so long. finally voters and politicians are waking up to that fact

Many leaders are used to not knowing how things work and getting good results anyway. In the case of AI, they believe and act like it is literally smart. chaos ensues. no one is held accountable

The difference between chatbots and bespoke deep neural nets is real and important, but the media and tech industry want to flatter themselves by flattening the landscape with the term “AI”, often diminishing human efforts along the way

first question on the application? who won the 2020 election screening process? the Family Guy color chart

The killer app for cryptocurrency was crime. there’s every reason to be AI-powered cybercrime is about to explode (is already exploding?)

Watched this in a theater in Oakland with a big crowd and it was tense af! At the end it was just stunned silence for about thirty seconds until someone stormed out cursing

it's an incredible run from IN PREPARATION “some organisms simply do not improve no matter how much selective pressure you apply. Alexi Lalas, for example.”

[biologist]: i'm setting up an NHS ester conjugation [chemist]: ok cool. sounds... pretty damn easy - in water - what? - at micromolar concentrations - are you...? - half the nitrogens are occluded - dude.

The distinction between “AI” as chatbots and “AI” as bespoke deep neural networks is more important than “AI” boosters care to admit!

I’m a chemical biologist. It’s NHS esters all the way down. I wonder if @dereklowe.bsky.social is doing any of his amide couplings in water. Cut it with some solvent and you’ve almost got a respectable reaction

The ultimate question is: how much data do you need to construct an oracle with a sufficiently smooth representational space (long enough correlation length) to make effective out of domain predictions. No one knows the answer. This project might be able to put a confidence bound on it

To be clear: a billion is not enough. A trillion is probably not enough. But it’s a start and it’s definitely worth it

this Perspective came out this week from a great group of SoCal scientists. I've been working in this field for a time and I couldn't agree more with the perspective. Super excited for the technologies and data this will yield "Mapping and engineering the human cell–cell interactome"