Dominic Denk
@domdenkmd.bsky.social
š¤ 94
š„ 516
š 22
MD | physician-scientist | GI-oncology and immunology. Likes ducks.
pinned post!
Excited to share our new study in
@nataging.nature.com
!š
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune
#aging
in a phase I trial!
#immunology
#aging
@loewe-fci.bsky.social
@goetheuni.bsky.social
#immunosky
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Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial - Nature Aging
Immune aging fosters multimorbidity and compromises control of infection and cancer. In a phase 1 randomized controlled trial in middle-aged adults, Denk and colleagues administer the mitophagy induce...
https://www.nature.com/articles/s43587-025-00996-x
about 2 months ago
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5
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reposted by
Dominic Denk
Science X / Phys.org
about 2 months ago
Urolithin A supplementation for 28 days shifted immune cell profiles in older adults toward a more youthful, less exhausted state and enhanced mitochondrial fatty acid oxidation capacity.
doi.org/g99kft
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Urolithin A nudges aging immune cells toward a youthful profile in 28 days
An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with additional functional gains.
https://medicalxpress.com/news/2025-11-urolithin-nudges-aging-immune-cells.html?utm_source=bsky.app&utm_medium=social&utm_campaign=v2
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7
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reposted by
Dominic Denk
Ruth Ann Crystal
about 2 months ago
In a RCT, Urolithin-A boosted CD8āŗ T cells and improved immune metabolism, hinting at a new way to slow age-related immune system decline and inflammaging.
buff.ly/qaGyGF0
Urolithin A works by inducing mitophagy (clearance of damaged mitochondria).
#medsky
#aging
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Excited to share our new study in
@nataging.nature.com
!š
www.nature.com/articles/s43...
We show that Urolithin A, a pomegranate-derived gut metabolite, counteracts key signs of immune
#aging
in a phase I trial!
#immunology
#aging
@loewe-fci.bsky.social
@goetheuni.bsky.social
#immunosky
loading . . .
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial - Nature Aging
Immune aging fosters multimorbidity and compromises control of infection and cancer. In a phase 1 randomized controlled trial in middle-aged adults, Denk and colleagues administer the mitophagy induce...
https://www.nature.com/articles/s43587-025-00996-x
about 2 months ago
2
5
2
reposted by
Dominic Denk
Frankfurt Cancer Institute
10 months ago
Happy to repost the study in
@cp-immunity.bsky.social
now with the cover illustrating the Janus-faced role of IL-17RA in
#colorectalcancer
. More information below by
@domdenkmd.bsky.social
or the latest issue of Immunity:
www.cell.com/immunity/cur...
#DarmkrebsmonatMƤrz
@proloewe.bsky.social
add a skeleton here at some point
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12
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reposted by
Dominic Denk
Immunity
10 months ago
Online now: Online now: IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
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IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
Members of the interleukin-17 family are associated with tumor progression in various settings. Denk etĀ al. find that, in colorectal cancer, IL-17RA switches from tumor promotion during early tumorigenesis to tumor suppression during tumor invasion andā¦
http://dlvr.it/TJGJRl
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reposted by
Dominic Denk
Frankfurt Cancer Institute
10 months ago
Fresh from
@cp-immunity.bsky.social
"A Surprising Shift from Foe to Friend: Researchers discover dual role of inflammatory signaling in colorectal cancer" šCongratulations
@domdenkmd.bsky.social
and all coauthors!! š Read the full article here:
www.cell.com/immunity/ful...
@proloewe.bsky.social
add a skeleton here at some point
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Finally announcing our new study in
@cp-immunity.bsky.social
! We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)!
#immunosky
#cancer
#immunology
@loewe-fci.bsky.social
@cellpress.bsky.social
@goetheuni.bsky.social
Read hereš§µš:
tinylink.net/OS41F
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IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
Members of the interleukin-17 family are associated with tumor progression in various settings. Denk etĀ al. find that, in colorectal cancer, IL-17RA switches from tumor promotion during early tumorige...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00073-1
10 months ago
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reposted by
Dominic Denk
Christian Frezza
11 months ago
Good morning, all. A rich and diverse list of curated papers in
#cancermetabolism
and
#mitochondrialbiology
is ready for you! Don't miss it! Find it here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
"In the midst of winter, I found there was, within me, an invincible summer."-Albert Camus
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reposted by
Dominic Denk
Christian Frezza
about 1 year ago
Good Sunday, all! A short but rich summary of papers in
#cancermetabolism
and
#mitochondrialbiology
is waiting for you here:
biomed.news/bims-camemi/...
@biomednews.bsky.social
#dontstopreading
āThe Eyes See Only What The Mind Is Prepared To Comprehend.ā ā Henri Bergson
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