Mitchell Stark (@thestarklab.bsky.social)

Clinically-normal skin harbours widespread, sub-clinical fields of BRAF V600E-mutant melanocytes, which are oncogene-primed but apparently dormant. These fields concentrated around naevi & melanomas may represent a field cancerization. @thestarklab.bsky.social url: academic.oup.com/bjd/article/...

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Subclinical Fields of BRAF V600E-Mutant Melanocytes Populate Human Skin and Are Enriched Around Melanoma and Naevi The origins of cutaneous melanoma are often traced to visible precursor lesions (e.g., melanocytic naevi), but ∼2/3 melanomas arise from clinically normal https://academic.oup.com/bjd/article/doi/10.1093/bjd/ljaf412/8304794