We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...

#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...

Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

I’m thrilled to report on work I led with Dr. Shawn Hervey-Jumper and Dr. Todd Hollon which shows that we can forecast where glioblastoma will recur even at time of initial resection. It’s wonderful to see all the work I conducted during my research year @neurosurgucsf.bsky.social come together!

Very excited to see this out and happy to have contributed!

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy. Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/... Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏 jitc.bmj.com/content/13/7...

🔥Trio Fatale: Neutrophils, NETs and Necrosis 👉 authors.elsevier.com/a/1lk-k3qNrU... We summarized for @cp-immunity.bsky.social "Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau Congrats!

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

How do #metastases survive (and thrive!) in the #brain microenvironment? In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases: Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

Congratulations to Mahak Singhal @uniheidelberg.bsky.social on being awarded an @erc.europa.eu Starting Grant for his project "Vascular-Rhythm" focussing on "DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation". Pioneering a new branch of vascular research!

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

We’re thrilled to share our latest publication in @cp-cancercell.bsky.social and very proud of C. Rozalén for this tour de force uncovering how TIM3⁺ breast cancer cells drive immune evasion during micrometastasis. #CancerImmunology #BreastCancer #Metastasis www.cell.com/cancer-cell/...

Today is the abstract deadline! Please join us to discuss the next steps and future perspectives of #cancerneuroscience at the @helloeacr.bsky.social conference in Bilbao 🤩

Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis https://go.nature.com/46c474I

We have already received many interesting abstracts for the Cancer Neuroscience EACR Conference in Bilbao, Spain.... ...and we are looking forward to reading *yours*! 🧠🔬 📢 Abstract Deadline June 30th 📢 #cancerneuroscience #neuroscience #cancer @helloeacr.bsky.social

The pioneer of cancer neuroscience, @michellemonje.bsky.social along w/ Frank Winkler @brainprize.org , profiled @thelancet.com today @stanforduniversity.bsky.social @stanfordmedicine.bsky.social www.thelancet.com/journals/lan...

Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling: Cell www.cell.com/cell/fulltex...

Reposting as I hear about a German Pubmed-like initiative: let's build on Europe PMC which is already great

New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇

I am delighted to share that our work focused on anti-tumor immunity in the leptomeningeal space was published today: www.nature.com/articles/s41... @meningojan.bsky.social

Meet GEQO: Genetically-encoded biosensors for absolute small-molecule quantification in single cells brought to you by @sascha-kuhn.bsky.social. For simple absolute quantification of your favourite small molecule or ion, head on over to @bioarxiv and read our new preprint: doi.org/10.1101/2025...

😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social

Huge congrats @lukasbunse.bsky.social, so well deserved, fantastic achievement. @hlsalliance.bsky.social @cn-hd.bsky.social @neurooncologyhd.bsky.social @mctneuroscience.bsky.social @platten-lab.bsky.social

#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler. www.nature.com/articles/s41...

It was my pleasure to write a Preview of the paper www.sciencedirect.com/science/arti... together with @venkataramanilab.bsky.social ! 🧠 #cancerneuroscience #glioblastoma The preview is now online @cp-neuron.bsky.social 👇

📢 We are excited and honored to announce that Frank Winkler received #thebrainprize2025, together with @michellemonje.bsky.social, for pioneering the field of #cancerneuroscience. 💐 @brainprize.bsky.social #neuroscience #cancer brainprize.org

Did you know cancer cells can be electrically active, just like neurons? This electrical activity plays a key role in tumor progression. Excited to share my first postdoc paper at @crick.ac.uk (and first paper from Leanne Li lab), published in @natureportfolio.nature.com!

Thrilled to share that our work from Trumpp Lab @hi-stem @dkfz.bsky.social is out in Nature. We provide the first single-cell data on neurons infiltrating pancreatic tumors, offering new insights into cancer therapy. #cancerneuroscience @cn-hd.bsky.social www.nature.com/articles/s41...

#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology

Ich hab mir doch nochmal die Mühe gemacht, nachzuzählen, ich komme auf genau 400 Teilnehmende, eventuell durch Schirme verdeckte und fälschlich als Gesicht gezählte Hände dürften sich etwa ausgleichen

Crick researchers have found that certain aggressive lung cancer cells can develop their own electric network, similar to the body’s nervous system. This can allow tumour cells to go ‘off grid,’ making them harder to treat. www.crick.ac.uk/news/2025-02...

Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity. www.nature.com/articles/s41...

🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma. 🔬 Key findings: ✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient ✅ Kills glioblastoma cells with no off-target effects ✅ Eliminates tumors in murine brain models 🔗 www.nature.com/articles/s41...

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen www.nature.com/articles/s41... @lukasbunse.bsky.social @naturecomms.bsky.social

Oxidative Phosphorylation (OXPHOS) Promotes the Formation and Growth of Melanoma Lung and Brain Metastases https://www.biorxiv.org/content/10.1101/2025.01.23.633049v1

📢 The next virtual Cancer Neuroscience Heidelberg Seminar, by Leanne Li, will be next Tuesday from 5-6 pm CET. Register now: us06web.zoom.us/meeting/regi... Cancer Neuroscience is funded by the European Center for Neurooncology (EZN) - Dietmar Hopp Stiftung

Out now in @cp-neuron.bsky.social: We found that the parental source of the transgene influences amyloid plaque load in 5xFAD mice, highlighting the need to clearly report breeding schemes to support the consistency and reproducibility of AD research using this model. www.cell.com/neuron/fullt...

New paper from our lab just out in @cp-cancercell.bsky.social! Integrating spatial omics, cell co-cultures and staining of clinical trial samples, we show that CD74 marks the right local microenvironment for #immunotherapy response. Excitingly, this may increase the number of treatable patients!

new out in Nature: lovely paper www.nature.com/articles/s41...

Epigenetic regulation of placental vascularization - now published in Developmental Cell (www.sciencedirect.com/science/arti...). Congratulations & thanks to Stephanie Gehrs for fantastic work and paving the way of the www.augustinlab.de into the world of vascular epigenetics. There’s more to come!