Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://nej.md/4nWaxvM #ASCO26

Thrilled to share our new paper out today in @NatureCancer:A single dose of RT makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues. (1/14) nature.com/articles/s43018-026-01167-6

Researchers at the Crick have uncovered how lung tumours can hijack the activity of nearby nerves to weaken the body’s immune response. This research was led by Ya-Hsuan Ho and Giacomo Bregni, with corresponding author Leanne Li. www.crick.ac.uk/news/2026-05...

Happy #FluorescenceFriday! Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation. More in our recent preprint : www.biorxiv.org/content/10.6...

Our new preprint on calcium signaling in brain metastases is now on bioRxiv! Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!

Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...

How does the nervous system influence cancer ... and vice versa? Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead. www.sciencedirect.com/science/arti...

The UK rejoining Erasmus is the best science news for a while! #AcademicSky www.gov.uk/government/n...

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression @cellcellpress.bsky.social www.cell.com/cell/fulltex...

Here are a couple of examples. Lung cancer survival rates for EGFR+ mutated Lung cancer.

It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s41... And a special shoutout to the lead author @snaga13.bsky.social A 🧵

🔬 Watch how cancer and immune cells interact in a living system. Scientists at BCI have developed mini lab-grown ovarian tumours that recreate the complex neighbourhood of cells in patients. Published today in @natcomms.nature.com. Read more: bit.ly/4bMCrVg 🧪 #medsky #oncosky @qmul.bsky.social

AP-1 mediates cellular adaptation and memory formation @natcomms.nature.com @pennmedicine.bsky.social @arjunraj.bsky.social @penngenetics.bsky.social www.nature.com/articles/s41...

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Humanity is notorious for leaving problems for the next generations, but animals reveal the biology: C. elegans develop germline tumors if THEIR GRAND GRANDPARENTS’ cells fail to clear garbage from their body cavity… What the hell, you ask? Read our new preprint! 👇 www.biorxiv.org/content/10.6...

Two Crick group leaders are joining Cancer Grand Challenges teams to tackle big questions in cancer research. Leanne Li leads a team studying how tumours interact with the nervous system, and Vivian Li joins a @ucl.ac.uk-led team working to rewire cancer cells. 🔗 www.crick.ac.uk/news/2026-03...

@simoncleary.bsky.social, Longhui Qiu, Mark Looney et al. developed a new #intravital technique for imaging pulmonary lymphatics. rupress.org/jem/article/... 📘 In our #Lymphatics collection: rupress.org/jem/collecti...

This week, we're joined by @drwilliamhill.bsky.social from @cruk-mi.bsky.social for the next in our @britsocimm.bsky.social MIG Seminar series: "Signals and Mechanisms of Lung Cancer Promotion by Air Pollutants” 📆 Thursday 19th Feb 🕛 12:00 PM 📍 Michael Smith Lecture Theatre #ImmunoSky

“Trust in scientists is gone!” Maria Leptin points to USA, adding: “To be resilient we must trust that the best researchers know where the scientific frontiers lie and keep diversity in research now for our future. Blue sky science is key to be prepared.” BMW Foundation Energy Security Hub

The February issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features work by @danielazorin.bsky.social, Dirk Hoffmann, Sophie Heuer, Frank Winkler, et al. on targeting tumor microtubes to disrupt GBM cell networks. Read that & more: aacrjournals.org/cancerdiscov...

Tumor-associated macrophages directly stimulate neurite outgrowth, revealing a dual role in enhancing intratumoral nerve growth and promoting neural repair after severe spinal cord injury @cp-immunity.bsky.social www.cell.com/immunity/ful...

So cool - someone finally hacked 'the vault'. www.science.org/doi/10.1126/...

An in-depth analysis of nutrient availability across mouse tissues reveals their influence on the spread of cancer to other organs @mghsteelelabs.bsky.social @harvardmed.bsky.social @geochurch.bsky.social www.nature.com/articles/s41... @nature.com www.nature.com/articles/d41...

Nature research paper: Transient hepatic reconstitution of trophic factors enhances aged immunity go.nature.com/4pD0f3H

www.cell.com/neuron/fullt... new paper from our group demonstrating how breast tumors dysregulate rhythms in the HPA axis to drive their own growth. Great collaboration with the @corina-amor.bsky.social and @cheadlelab.bsky.social labs @cshlnews.bsky.social

Fifteen Years xkcd.com/3172/

📢 Registration (free!) for the NCI webinar series 'Fueling Cancer Progression by the Nervous System' is open! 🧠🔬 Amongst many excellent speakers, Frank Winkler and @venkatesh-lab.bsky.social discuss #cancerneuroscience of #brainmetastasis 📅 6 exciting topics are covered by leaders in the field 💡!

New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇 www.biorxiv.org/content/10.1...

We're pleased to announce that @charlesswanton.bsky.social is the 2026 winner of the Mike Price Gold Medal Award! The award will be presented at the EACR 2026 Congress in Budapest, where Charles will present the Keynote Award Lecture. Congratulations 🎉 learn more: magazine.eacr.org/charles-swan...

Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction @cellcellpress.bsky.social www.cell.com/cell/fulltex... @charlesswanton.bsky.social @ucl.ac.uk

We are introducing LipiGo 🤗 A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

🧵1/17 📣Thrilled to share our latest study just out in Cancer Discovery! ➡️ aacrjournals.org/cancerdiscov...

#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...

Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

I’m thrilled to report on work I led with Dr. Shawn Hervey-Jumper and Dr. Todd Hollon which shows that we can forecast where glioblastoma will recur even at time of initial resection. It’s wonderful to see all the work I conducted during my research year @neurosurgucsf.bsky.social come together!

Very excited to see this out and happy to have contributed!

My main PhD project is out in #CancerDiscovery @theaacr.bsky.social We found that PKC activators (TPPB) destroy tumor microtube networks that glioblastoma cells use to invade & resist therapy. Huge thanks to my first co-author @dirkchoffmann.bsky.social , @winklerlab.bsky.social & all co-authors!

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/... Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏 jitc.bmj.com/content/13/7...

🔥Trio Fatale: Neutrophils, NETs and Necrosis 👉 authors.elsevier.com/a/1lk-k3qNrU... We summarized for @cp-immunity.bsky.social "Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau Congrats!

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

How do #metastases survive (and thrive!) in the #brain microenvironment? In our review, now online @cp-neuron.bsky.social, we discuss the recent findings on #cancerneuroscience of #brainmetastases: Learn all about how #cancer cells adapt to, and communicate with, this unique environment 🧠

Congratulations to Mahak Singhal @uniheidelberg.bsky.social on being awarded an @erc.europa.eu Starting Grant for his project "Vascular-Rhythm" focussing on "DeClocking the vascular rhythmic control of tissue homeostasis and disease initiation". Pioneering a new branch of vascular research!

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Excited to share our new work, led by an exceptional graduate student, Tornike Mamuladze, on the role of meningeal mast cells in regulation of brain/dura access points, with implications to CSF flow dynamics and meningitis || www.cell.com/cell/fulltex...

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...