It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social

Paul Nurse describing the main job of a PI (From ‘The Thinking Game’, 2024)

6 incredible years. So grateful for the opportunity to work with such brilliant people. What an adventure. Goodbye @crick.ac.uk

To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer. #AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk

Fantastic insight into NSCLC, going from biology to interception

Imaging mass cytometry of 122 early stage lung adeno patients explores the balance of of the tumour microenvironment and changes in malignant cell fate.

New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)

It is with great sadness to hear that the great Tim Radford has died. He was, unequivocally, the best science journalist, and a kind and generous man. I used his Manifesto for the Simple Scribe in lectures for student this very week. It’s faultless. www.theguardian.com/science/blog...

I had a fantastic day at the CRUK workshop last week at the intersection between aging and cancer.

That's cool

At individual level those who vape more likely to go on to smoke (but causality not proven) but at population level higher levels of youth vaping could mean lower levels of youth smoking - really important work from @jhb19.bsky.social showing how carefully we need to keep the evidence under review

Today our study using copy number alterations (CNAs) from low-coverage WGS to predict FUTURE colorectal cancer in patients with IBD is published, details in thread! 1/5 gut.bmj.com/content/earl...

One of my frustrations with our work to understand the causes of #cancer #cachexia as part of Cancer Grand Challenges Team #CANCAN is the limitation of animal models that don't reflect the realities of the patient population. This development helps. #LCSM #lungcancer www.biorxiv.org/content/10.1...

Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma https://buff.ly/4akMe3C While further prospective validation is required, this approach could significantly enhance risk stratification and treatment planning in early-stage LUAD.

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis. Happy to share here: www.nature.com/articles/s41...

I'm delighted to announce that the Pharma Proteomics Project will commence full-scale proteomic profiling of the UK Biobank in 2025. We have selected the Olink Proteomics Explore HT platform and Ultima Genomics UG 100 sequencers for this unprecedented study. www.ukbiobank.ac.uk/learn-more-a...

"unlike type 1 immune responses, type 2 immunity is perceived as a potential promoter of tumorigenesis. Emerging evidence challenges this perspective, painting a more nuanced picture in which type 2 immunity might protect against or even actively suppress tumour growth and progression." #ImmunoSky

Metabolic changes at the interface between mutant and normal skin epidermis www.nature.com/articles/s41...

Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer. https://www.biorxiv.org/content/10.1101/2024.12.31.630523v1

Beyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨ -> go.nature.com/4gCYtuL A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏 A brief 🧵

2024 was a year of exciting discoveries and scientific discussions! A thread 🪡 of this years’ publications from our lab 👇🏼

Breathing polluted air increases the risk of osteoporosis. #Science Open Access www.science.org/doi/epdf/10....

New insights for brain aging via spatial clocks and A.I.: rare, neighboring cells can have big impact (T cells for promoting inflammation + aging; neural stem cells for slowing aging) www.nature.com/articles/s41...

How much do algorithmic and experimental choices drive the accuracy of reconstructing tumour evolution? In this Cancer Research commentary, @zaccasimo.bsky.social and I discuss a recent Nature Biotech benchmarking paper exploring this question: bit.ly/3VAMRQs

An early holiday present from the @MorriseyLab! A story of stem cell collision/competition driving lung regeneration. A tour de force by Dakota…#WhyWeScience! www.science.org/doi/10.1126/...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Highly recommend (long) read for anyone who's been leading a lab 10+ years!

More rhythms impacting how our bodies respond, in this case to chemo, and the underlying biology.

BLUESKY MEGA-THREAD Altmetric is thrilled and also LITERALLY RELIEVED to officially announce: We are now tracking research attention as it happens on Bluesky! We have been picking up posts on the site since late Oct. Our team is on Bluesky all day answering questions. Let's get into it!

Lots to dive into in this multiomic analysis of >200 Korean NSCLC cases combined with other multiomic studies www.nature.com/articles/s41...

Fascinating & unexpected from the Rodriguez lab on cell competition acting as a nutrient sensor Winner cells increase L-Proline uptake in losers, repressing their survival pathway (ISR) to kill them Explains old observations that starvation prevents competition www.biorxiv.org/content/10.1...

Sometimes I read a pre-print that moves the needle, typically on bioRxiv where all the good new stuff first appears. Two first class tech-dev pioneers and their fearless postdocs collaborate creating tour de-force methods --> www.biorxiv.org/content/10.1...

What else is in the blood we could use for early detection?

Thoroughly enjoyed this night science episode with Prof Richard White. That's where all his fantastic ideas come from open.spotify.com/episode/1aQ4...

Thrilled to share our story out in Cancer Cell, led by the amazing Kay Hanggi (now on the job market). We show that necrotic forms of cell death and the subsequent release of IL1a drives myeloid-based immune suppression in models of breast cancer. (1/11) www.cell.com/cancer-cell/...

How to write a grant? 1. The application is for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. www.pnas.org/doi/epub/10....

The Vaishnavi Lab is hiring a new RAII! Interested in learning more about mouse models of lung cancer? jobs.mdanderson.org/search/jobde... Please RT! #lcsm #AcademicChatter

'An expanded view of cell competition' journals.biologists.com/dev/article/...

Aneuploid epithelial cells in normal breast tissue. Fascinating! www.nature.com/articles/s41...

We’ve renewed funding for our Lung Cancer Centre of Excellence for the next 5 years! With up to £4m support from our partner ScottishPower, researchers will continue to find new ways to beat #LungCancer 👇 @cruk-mi.bsky.social @thecrick.bsky.social news.cancerresearchuk.org/2024/11/20/4...

Have had a go at a lung health starter pack: #LungSky go.bsky.app/UAR96WC Let me know if I've missed you out. #COPD #Asthma #Emphysema #Breathless #Cough #Wheeze #FCTC #TobaccoControl #StarterPack

Mind blowing talk by James DeGregori on viral infection, awakening, and maintenance of metastatic outgrowth. Not good news for those of us that have had multiple Covid-19 infections. #AACRtumorenviron24

More data highlighting how cell of origin and lineage plasticity may alter lung cancer phenotype. Elegant story exploring basal cells in SCLC www.biorxiv.org/content/10.1...

We invite you to the “Cell Plasticity in Cancer Evolution” workshop at the MPI Evolutionary Biology, May 19–22, 2025! Join international experts who will share insights on cell plasticity in cancer and the latest research and therapies. Registration: workshops.evolbio.mpg.de/event/123/ov...

Here's a starter pack that focusses on lung biology, regeneration and cancer. Let me know who I'm missing! go.bsky.app/VC83FZm

Pest managers have developed 10 principles that could be translated to controlling cancers

Upcoming Development Special Issue 'Lifelong Development' Beyond the embryo: tissue maintenance, regeneration & plasticity Guest eds: Meri Huch & Mansi Srivastava Deadline: 15 May 2025 All article types welcome #DevBio #Regeneration #StemCells journals.biologists.com/dev/pages/li...