Rob Hynds
@robhynds.bsky.social
📤 2221
📥 1596
📝 26
Scientist studying epithelial biology, stem cells and cancer at UCL (
@epicentr.bsky.social
) 🫁
reposted by
Rob Hynds
Epithelial Cell Biology in ENT Research Group UCL
25 days ago
Lizzie Maughan
@uclchildhealth.bsky.social
led this collaboration with Wenhui Song's lab to develop a bespoke airway stent for use in a 5-month-old with near-complete laryngeal stenosis. The novel 3D-printed stent enabled safe airway reconstruction. 📄
doi.org/10.1002/adfm...
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A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction
A programmable interpenetrating double-network architecture, created via 3D-TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural....
https://doi.org/10.1002/adfm.202513861
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Rob Hynds
Michael Eisen
about 2 months ago
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!!
formatmypaper.com
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reposted by
Rob Hynds
Epithelial Cell Biology in ENT Research Group UCL
3 months ago
Our latest work is available on BioRxiv! WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
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WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells
Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...
https://www.biorxiv.org/content/10.1101/2025.09.15.675861v1
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Rob Hynds
ATS Red Journal
4 months ago
📣Call for Papers!📣 We aim to showcase work that investigates the underlying mechanisms for lung repair in health and disease, including lung development 📆Deadline: December 31, 2025 🔬Learn More Here:
tinyurl.com/ye24jb76
🖱️Submit here:
tinyurl.com/yahzwj8k
@atscommunity.bsky.social
#medsky
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Rob Hynds
James Reading
4 months ago
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only
www.ucl.ac.uk/medical-scie...
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Pre-Cancer Immunology
The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.
https://www.ucl.ac.uk/medical-sciences/divisions/cancer/our-research/pre-cancer-immunology
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The AJRCMB Call for Papers on Lung Repair Models and Mechanisms - launched at the Vermont Stem Cell Conference earlier this month - is now open! Please consider submitting your next paper here. Thanks to Janette Burgess and Andrew Halayko for making this happen 🙌
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4 months ago
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It was an honour to co-chair the 20th Anniversary Vermont Lung Stem Cell Conference in Vermont last week. Grateful to Amy Ryan,
@skocguen.bsky.social
& Dan Weiss, our planning teams, and everyone who joined us. Excited to return to Burlington in 2027!
5 months ago
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Great to see Krijn’s work from
@crick.ac.uk
published! He developed clonal organoid lines from NSCLC tumours and PDX models. Immune evasion varied between clones from the same tumour, highlighting intratumour heterogeneity and providing a model to study it.
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5 months ago
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Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit.
www.science.org/doi/10.1126/...
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A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.
https://www.science.org/doi/10.1126/scitranslmed.adu2459
5 months ago
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reposted by
Rob Hynds
Jess Orr
5 months ago
Had a wonderful time at the
@bsgct.bsky.social
annual conference! I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the
@epicentr.bsky.social
efforts towards a cell and gene therapy for airway epidermolysis bullosa.
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Great to see so many familiar faces registered for the 20th Anniversary Stem Cells, Cell Therapies & Bioengineering Conference in Burlington in July. There’s still time to register and for trainees to book a spot on the unique pre-conference workshops.
t.co/vbsFFhaeAZ
6 months ago
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reposted by
Rob Hynds
Soragni:Lab
7 months ago
This is quite amazing, the team identified some exceptionally powerful neutralizing antivenom antibodies and are working toward a universally protective cocktail. Brilliant, and all it took was for a single person to get bitten by snakes some 200 times....
www.cell.com/cell/fulltex...
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Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies
To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a combination of two of the identifie...
https://www.cell.com/cell/fulltext/S0092-8674(25)00402-7
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reposted by
Rob Hynds
Sergio Cruz-León
8 months ago
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/
@jpkreysing.bsky.social
,
@johannesbetz.bsky.social
,
@marinalusic.bsky.social
, Turoňová lab,
@hummerlab.bsky.social
@becklab.bsky.social
@mpibp.bsky.social
🔗 Preprint here
tinyurl.com/3a74uanv
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reposted by
Rob Hynds
Epithelial Cell Biology in ENT Research Group UCL
8 months ago
🚨Today our phenotypic screening work with primary human airway basal cells is published
@jcellsci.bsky.social
! We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
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Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.
https://doi.org/10.1242/jcs.263487
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reposted by
Rob Hynds
MRC-LMB Cell Biology Division
8 months ago
A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'.
journals.biologists.com/jcs/article/...
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Remembering David Stephens (1971–2024)
In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...
https://journals.biologists.com/jcs/article/138/7/jcs263972/367609/Remembering-David-Stephens-1971-2024
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reposted by
Rob Hynds
London Stem Cell Network
9 months ago
Don't forget to secure your place and submit your abstract for the LSCN 8th Annual Symposium! 🔗Registration:
eventbrite.co.uk/e/8th-annual...
Website:
lscn.co.uk
(where the final agenda will be published soon) Abstract submission (deadline 04/04!)
docs.google.com/forms/d/e/1F...
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reposted by
Rob Hynds
Stephen Curry
9 months ago
It's a start I suppose.
www.theguardian.com/science/2025...
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Scientists aiming to bring back woolly mammoth create woolly mice
Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants
https://www.theguardian.com/science/2025/mar/04/genetically-modified-woolly-mice-mammoth
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reposted by
Rob Hynds
London Stem Cell Network
10 months ago
LSCN Members can access a code for free registration! Become a member by registering on our website
lscn.co.uk
and find the free code on the symposium page!
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Home - London Stem Cell Network
https://lscn.co.uk
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Ras inhibition in CAFs reduces their activation and decreases tumor burden. Awesome new work from collaborator Esther Castellano's team 👏
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11 months ago
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reposted by
Rob Hynds
Epithelial Cell Biology in ENT Research Group UCL
12 months ago
Happy holidays from everyone in the EpiCENTR group! Follow
@jess0rr.bsky.social
and
@drewfarr.bsky.social
for our latest throughout 2025 🎁 (h/t
scholargoggler.com
)
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This radiotracer can distinguish high/low NRF2 antioxidant pathway activation, including in our TRACERx lung cancer PDX models! Great to see the manuscript out, congrats Tim and team! 👏
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12 months ago
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reposted by
Rob Hynds
Early bird registration ends 20th Dec - register early!
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12 months ago
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Early bird registration ends 20th Dec - register early!
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12 months ago
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reposted by
Rob Hynds
Amoyel lab
about 1 year ago
We're hiring a postdoc! Please forward to people you know who are looking for positions. Interested in studying how metabolism is wired to support fertility? 🔬🪰 Come join us! Ad to go live next week, but informal enquiries encouraged.
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Our TRACERx lung cancer patient-derived-xenograft (PDX) models are now available to the research community at
CancerTools.org
! 🎉 Huge thanks to Dave Pearce,
@charlesswanton.bsky.social
and the brilliant CRUK LCCE team who have made this possible. Find out more here:
cancertools.org/nsclc-pdx-mo...
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Home
CancerTools.org is part of Cancer Research UK. Discover a global, non-profit, cancer research tools biorepository
http://CancerTools.org
about 1 year ago
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Here's a starter pack that focusses on lung biology, regeneration and cancer. Let me know who I'm missing!
go.bsky.app/VC83FZm
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about 1 year ago
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Registration for the 20th Anniversary Vermont Lung Stem Cells meeting is open! 🌟 Hands on bioinformatics or lab techniques workshops. 🌟 Great speakers including
@kottond.bsky.social
,
@tatalab-duke.bsky.social
& many others not yet here! 📅 7-10th July 2025 📍 Burlington, VT 🕸️
go.uvm.edu/stem25
about 1 year ago
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👋🦋 I'm a junior group leader at the UCL Institute of Child Health (
@epicentr.bsky.social
). We work on airway epithelial cell biology and cell/gene therapy for rare diseases, particularly epidermolysis bullosa. Good to see so many familiar faces here. Looking forward to connecting/re-connecting!
about 1 year ago
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