Celebrating a milestone! On the occasion of Dr. Rakesh Jain's 75th birthday & the 40th anniversary of the TME course, colleagues & collaborators have contributed to a Festschrift published in Cellular and Molecular Bioengineering. A thread of the first 5 articles:

Publication Alert @natureportfolio.nature.com 🚨 - Organ-specific breast cancer metastasis reflects complex nutrient–tumor interactions, not single metabolites. Purine synthesis is a conserved vulnerability. rdcu.be/eX1L7

🚨 New from our lab in @PNASNews: We developed a physiologically based model to optimize CAR-T therapy in solid tumors. Vascular normalization can cut CAR-T doses 5x & boost efficacy in tough tumors like glioblastoma & PDAC. www.pnas.org/doi/10.1073/... @mgbresearch.bsky.social

Excited to share our recent discovery on combination therapy strategies to overcome treatment resistance in glioblastoma, now highlighted by @MassGeneralNew @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...

Publication alert 🚨 Mutant p53 hijacks enhancers to drive CXCL1 expression and create an immunosuppressive TME in #PDAC. Targeting these enhancer-chemokine circuits could boost immunotherapy in PDAC. t.co/K84OB4NlOx #MGHCancerCenter #kochinstitute @harvardmed.bsky.social

Honored to see our Director, Dr. Rakesh Jain, recognized for his pioneering work in intravital microscopy and the tumor microenvironment. A true visionary in cancer research! #AACR25 #TME #IntravitalMicroscopy

We caught up with the @theaacr.bsky.social Award for Lifetime Achievement in Cancer Research winner, Rakesh Jain (@harvardmed.bsky.social) to discuss his pioneering work in the tumor microenvironment and invention of the intravital microscopy imaging method. www.biotechniques.com/cancer-resea...

New publication Alert! We developed a mathematical model to decipher how the gut microbiome shapes cancer immunotherapy response. Key insight: Microbiome composition influences immune cell activation & killing rates—critical for tumor control. @harvard.edu @mghsteelelabs.bsky.social

We review how mathematical modeling and AI can be combined to improve delivery & efficacy of molecular, nano, antibody & cellular therapies in solid tumors. www.nature.com/articles/s41... #TME #AIinOncology #CancerResearch @harvard.edu

Dr. Rakesh Jain of @mghsteelelabs.bsky.social shared insights from his decades-long work on vascular normalization—from concept to clinic. His lecture emphasized strategies to improve tumor vessel function and how these principles are transforming cancer therapy today. #AACR2025 @harvard.edu