An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Our first lab paper is out! We identify and solve the first structure of the SND3 translocon involved in fungal membrane protein insertion. Congratulations @tzujingyang.bsky.social, and our colleagues @saumyakm.bsky.social, @hummerlab.bsky.social and Julian Langer. Read more ⬇️ and ➡️ rdcu.be/eNgIO

Genuinely delighted to download a PhD thesis from a university repository where the author has neglected to remove the words "BITCH THIS IS YOUR THESIS" from the filename.

The latest work from the Marlovits group in collaboration with the Sartori group. Victor used Elastic Strain Analysis to complement Jiři's original Staring at the Structures for Ages Analysis and understand the chemo-mechanical coupling of the RuvAB AAA+ ATPase

The German company that makes the mechanical ladder used in the Louvre heist has used the image to advertise, with the text 'When you need to move fast' 10/10 response, no notes

Looking for a PhD? 🚀 MIBTP projects are out lots to explore! 🔬 #Bacteria • #AMR • #Interdisciplinary • FUN! My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry. warwick.ac.uk/fac/cross_fa...

Finally, just about 2 years after finishing the postdoc the last part of my work is finally online! We determined the structure of HSV-1 Origin Binding Protein, the viral initiator of DNA replication, by cryo-EM 🧪🧬🧶🧵 #cryoEM #structuralbiology

Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧

As it is International Wombat Day, I must share this by Dante Gabriel Rossetti (ostensibly) concerning his pet wombat: OH how the family affections combat Within this heart, and each hour flings a bomb at My burning soul! Neither from owl nor from bat Can peace be gained until I clasp my wombat.

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Been playing down at the beach

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here: emploi.cnrs.fr/Offres/Docto...

🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social&@chipericson.bsky.social trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬 www.biorxiv.org/content/10.1...

Explaining to my wife that I cannot simply “read the books I’ve already bought and haven’t read” like some kind of peasant.

Become my colleague @oxfordbiochemistry.bsky.social ! 2 Associate Professorships in the areas of - prokaryotic/eukaryotic microbiology - metabolism my.corehr.com/pls/uoxrecru...

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.

PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this

Structure and substrate recognition by the Twin-arginine translocation (Tat) pathway core complex https://www.biorxiv.org/content/10.1101/2025.09.18.677151v1

An Infusiast

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

Is anyone in #MicroSky aware of the rapamycin dimerisation working in (myco)bacteria? Or some other inducible dimerisation? I'd like to give this a go but I'm wary of fusing a 24-mer to my protein of interest

Pretty pleased with my 3d-printed Jeol 1400. But does anyone in #TeamTomo or #cryoEM have a 3D model or technical drawings of a Krios/Aquilos/Arctis I could have a go at printing?

This looks super cool, and could be the solution to a problem I've been having for a while. Congrats all!

Since search is dead, how soon do you think Google Scholar is headed for the Google Graveyard? I'm betting it's soon, and academia is NOT prepared

This was a brilliant course last year; I highly recommend it to anyone looking to improve their CryoFIB and CryoET skills!

1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.

Congratulations @emfurlong.bsky.social !

That means it's 10 years since I did my summer project at @diamondlightsource.bsky.social. How time flies!

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/ Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic ⚔️🦠❄️🔬

ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️‍💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

📣 Applications now open 📣 We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease! Please share! www.path.ox.ac.uk/work-with-us...

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms led by @abultarafder.bsky.social Great collaboration with @pearce-maths.bsky.social and @geiselbiofilm.bsky.social www.biorxiv.org/cgi/content/...

Are YOU the most depressing book plate ever? YES, You ARE!

My first attempt at recreating the lemon curd bun I had at Lune in Melbourne

Had a great long weekend forging a sword for me and baking a cake for Mum. Now experiencing the joys of Stansted for the flight home the Hamburg!

Former Marlovits postdoc Biao has a new preprint out! He managed to capture the CPS transporter Wza-Wzc with the inner and outer membrane components bound together, in various states of (dis)assembly. #MicroSky #CryoEM www.biorxiv.org/content/10.1...

Former Marlovits postdoc Biao has a new preprint out! He managed to capture the CPS transporter Wza-Wzc with the inner and outer membrane components bound together, in various states of (dis)assembly. #MicroSky #CryoEM www.biorxiv.org/content/10.1...

Fro the last few years, as part of a final assignment in my senior biophysical chem class I ask students to share a class-related memes, with ones they make themselves highly encouraged! For everyone's enjoyment, here are some of my favorites! #chemistry #biochemistry #sigfigs #units 🧪

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬 www.science.org/doi/full/10....

Pit stop for our Aquilos dewar got even easier with the 3D printed funnel from friendly Zurich team (shout-out to blueskyless Piotr Szwedziak)!

I did not know the pacarana was a creature that existed until today... I am delighted to say the least...

Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular

New method toward modeling cells and viruses! HMFF enables integrative membrane modeling and simulation guided by electron microscopy data. Created by Valentin Maurer and Marc Siggel @embl.org ‪‪@cssbhamburg.bsky.social‬, in collaboration with @WPezeshkian lab (1/n) www.biorxiv.org/content/10.1...

This, by Michael Lynch. I'd include AI techbros as well. www.pnas.org/doi/10.1073/...

Beautiful views from Carrauntoohil ☁️ 🇮🇪

Today is National Biscuit Day, and it’s about time that I populated this account with biscuit (cookie) sets from the past few years. Here are some of my favourites. 🧵 First up, a set inspired by the delicious designs of William Morris and John Henry Dearle.

😱 NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! 🤯 www.theguardian.com/science/2025...