Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.

PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this

Structure and substrate recognition by the Twin-arginine translocation (Tat) pathway core complex https://www.biorxiv.org/content/10.1101/2025.09.18.677151v1

An Infusiast

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

Is anyone in #MicroSky aware of the rapamycin dimerisation working in (myco)bacteria? Or some other inducible dimerisation? I'd like to give this a go but I'm wary of fusing a 24-mer to my protein of interest

Pretty pleased with my 3d-printed Jeol 1400. But does anyone in #TeamTomo or #cryoEM have a 3D model or technical drawings of a Krios/Aquilos/Arctis I could have a go at printing?

This looks super cool, and could be the solution to a problem I've been having for a while. Congrats all!

Since search is dead, how soon do you think Google Scholar is headed for the Google Graveyard? I'm betting it's soon, and academia is NOT prepared

This was a brilliant course last year; I highly recommend it to anyone looking to improve their CryoFIB and CryoET skills!

1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.

Congratulations @emfurlong.bsky.social !

That means it's 10 years since I did my summer project at @diamondlightsource.bsky.social. How time flies!

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/ Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic ⚔️🦠❄️🔬

ASS is short for acephalic spermatozoa syndrome in which head and tail of sperm are detached⛓️‍💥, commonly caused by mutations in the gene encoding for SUN5. Using in situ cryo-ET❄️🔬 we find that SUN5 forms a protein lattice in the nuclear envelope (NE) at the head-tail junction of mammalian sperm.1/4

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!! Make my day and check it out! www.biorxiv.org/content/10.1... #Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

📣 Applications now open 📣 We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease! Please share! www.path.ox.ac.uk/work-with-us...

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms led by @abultarafder.bsky.social Great collaboration with @pearce-maths.bsky.social and @geiselbiofilm.bsky.social www.biorxiv.org/cgi/content/...

Are YOU the most depressing book plate ever? YES, You ARE!

My first attempt at recreating the lemon curd bun I had at Lune in Melbourne

Had a great long weekend forging a sword for me and baking a cake for Mum. Now experiencing the joys of Stansted for the flight home the Hamburg!

Former Marlovits postdoc Biao has a new preprint out! He managed to capture the CPS transporter Wza-Wzc with the inner and outer membrane components bound together, in various states of (dis)assembly. #MicroSky #CryoEM www.biorxiv.org/content/10.1...

Former Marlovits postdoc Biao has a new preprint out! He managed to capture the CPS transporter Wza-Wzc with the inner and outer membrane components bound together, in various states of (dis)assembly. #MicroSky #CryoEM www.biorxiv.org/content/10.1...

Fro the last few years, as part of a final assignment in my senior biophysical chem class I ask students to share a class-related memes, with ones they make themselves highly encouraged! For everyone's enjoyment, here are some of my favorites! #chemistry #biochemistry #sigfigs #units 🧪

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬 www.science.org/doi/full/10....

Pit stop for our Aquilos dewar got even easier with the 3D printed funnel from friendly Zurich team (shout-out to blueskyless Piotr Szwedziak)!

I did not know the pacarana was a creature that existed until today... I am delighted to say the least...

Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular

New method toward modeling cells and viruses! HMFF enables integrative membrane modeling and simulation guided by electron microscopy data. Created by Valentin Maurer and Marc Siggel @embl.org ‪‪@cssbhamburg.bsky.social‬, in collaboration with @WPezeshkian lab (1/n) www.biorxiv.org/content/10.1...

This, by Michael Lynch. I'd include AI techbros as well. www.pnas.org/doi/10.1073/...

Beautiful views from Carrauntoohil ☁️ 🇮🇪

Today is National Biscuit Day, and it’s about time that I populated this account with biscuit (cookie) sets from the past few years. Here are some of my favourites. 🧵 First up, a set inspired by the delicious designs of William Morris and John Henry Dearle.

😱 NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! NEANDERTHAL FINGERPRINT! 🤯 www.theguardian.com/science/2025...

Congratulations Kevin!

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪

Postdoc position available! This is a 2-year post funded by the Academy of Medical Sciences. You'll be based in the Centre for Bacterial Cell Biology here in Newcastle, using super-resolution microscopy to look at the bacterial cell wall. 🔬🦠 Please re-post 🙏 www.jobs.ac.uk/job/DMY885/r...

1804. Oceans are now Battlefields. In the South China Sea a British convoy worth almost £1bn today is spotted by the French. It should be a massacre. Instead, Commodore Nathanial Dance is about to defeat a French battle squadron using some paint and the most overplayed hand in #navalHistory. /1 🧵

New paper out! We discovered a tiny archaeon with the smallest known archaeal genome — only 238 kbp! Candidatus Sukunaarchaeum mirabile has almost no recognizable metabolic pathways and may rely heavily on a host to survive. It also represents a novel, deep-branching lineage in the archaeal tree.

Plasmidsaurus now lives in Germany! Overnight sequencing for ALL of Europe! 🦖 Dropboxes in 14 European countries...and the dino is looking for MORE! Request your free dropbox here: shorturl.at/cplXq Big 💚 to Dr Jan Müller, PI at @i-med.ac.at, Austria, for starring in this video! shorturl.at/hVqud

Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection. www.sciencedirect.com/science/arti...

🧑‍🎓👩‍🎓We are hiring: PhD student positions in Molecular Infection Biology in DFG Research Training Group Humans and Microbes @cssbhamburg.bsky.social @leibnizliv.bsky.social @bosse-lab.bsky.social @linderlab.bsky.social @itzenlab.bsky.social #UKE #UHH #BNITM 📬Apply until June 20, 2025. grk2771.de

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

And here jobs.ncl.ac.uk/job/Newcastl...

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

GODDAMIT. IT’S NOT A RESURRECTED DIRE WOLF. 20 edits in 19,000 genes. IT’S NOT GOING TO AID CONSERVATION. EVERY WRITE UP THAT SWALLOWS AND REGURGITATES THIS GUFFERY WOLFSHIT IS DOING PR FOR A FUNDING ROUND.

THREAD Today Altmetric is announcing a major development in collaboration with the Brain Occipital Lobe Learning Observation Centre Kalhausen-Strasbourg. From today Altmetric will be able to determine what research paper you're thinking of, regardless of what you're actually writing/saying. 1/17

THREAD The numbers are in. @bsky.app research sharing volumes vs X Formerly Twitter In March 2024, on most days, Bluesky hosts more posts linked to research published in 2025 than X. By quite a lot. Release the Kraken... #AcademicSky #HigherEd #Altmetrics 1/11