Our latest T7SS study is now out in Science Advances! We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery. www.science.org/doi/10.1126/...

Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals. A big leap in understanding TB’s survival tricks and new angles for therapies. 📖 shorturl.at/Z8MVX ✍️ @genevauxpierre.bsky.social & coll. #MicroSky

PPE51 is one of the best candidates to form a MOM transport channel. However, our data indicate that it is not that simple. PPE51 mutations in Mmarinum (4 close homologs) indeed reduce the growth on glycerol & glucose, but also highly increase permeability.. and no, we do not fully understand this

www.nature.com/articles/s41... After 10 years they finally found the culprit… great work, although it is not so surprising that it turns out to be a Vibrio sp.

Reading: How a Biofilm’s Strange Shape Emerges From Cellular Geometry www.quantamagazine.org/how-a-biofil... via @QuantaMagazine

This biologist aims to solve the cell’s biggest mystery. Science | AAAS www.science.org/content/arti...

The #GRCMyco2025 group photo is now in everyone's mygrc folder! It was VERY sunny....

Krista Freeman et al 𝘊𝘌𝘓𝘓 stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm can inform precise targeted phage therapies for TB and NTM infections www.cell.com/cell/fulltex...

www.biorxiv.org/content/10.1... exciting new study on role of disulphide bond formation in secretion and motility in Bacteroidota

For all its prominence in research, E. coli is a blip in a rich microbial world. Scientists are rethinking our infatuation with microbiology’s superstar and considering what can—and should—constitute a model organism going forward. Read the article: asm.org/Articles/202...

Stopping clinical trials with such haste is unethical and potentially dangerous and violates the very principles that all who conduct interventional studies must adhere to. It is sad and exposes ignorance and a complete lack of respect for people!

New preprint 🚨: with @madejmar.bsky.social we found that the Bacteroidetes beta-barrel assembly machinery is quite different to E. coli. www.biorxiv.org/content/10.1... #cryo-EM

Last ever lecture in the infamous W&N building at the VU Amsterdam…apparently it had one of the longest hallways in the Netherlands, 250 meter.

How do animals compensate for trait loss? In beetles, symbiosis is a consistent strategy. Where the repeated loss of endogenous digestive enzymes is offset by functionally convergent symbioses: www.cell.com/current-biol... Excited to share our latest, out today in @currentbiology.bsky.social!

Researchers have engineered symbiotic associations between fungal cells and introduced organelles in an effort to explore how endosymbiosis might have given rise to eukaryotic cells. 🌱🐋🧪🦫🧠 #Evolbio

Out today! Our review on the current evidence of protein import into endosymbionts/early organelles. We cover protists, insects and plant systems, so something for everybody! With Mygg Stiller, Lena Kröninger and Eva Nowack. #protistsonsky #SymbioSky febs.onlinelibrary.wiley.com/doi/full/10....

A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity @naturemicrobiol.bsky.social @saehrt.bsky.social @joanneflynn19.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...

If you're interested in learning about the latest of fundamental mycobacteriology, sign up for #GRCMyco2025! Acceptances will start in September, check out the full program and please RT!

I made a Starter Pack for the Myco & TB community. Hope to find more good friends here on Bluesky to keep in touch about mycobacterial infections. Please join and repost! go.bsky.app/3nwpcVV

Together with Abdallah and Qingtian we just published this pan-genome analysis for M. marinum. I think it is a nice catalog, but standing out for me was the variation in the cpnT gene and the fact that ESX-2 is present in the majority of the M. marinum strains, just not in the type strain M...

Hello, I also switched to Blue and already was welcomed by some friends, thank you! Let's hope this platform will stay safe......