It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated! www.biorxiv.org/content/10.6...

Deadline to apply for MRC fully funded 4-year PhD studentships is approaching on *9 Jan 2026*! Join world-class researchers across @unibirmingham.bsky.social , @uniofleicester.bsky.social and @uniofnottingham.bsky.social 👉See more.bham.ac.uk/mrc-aim/phd-...

Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

Leeds researchers have secured two major Wellcome Trust Discovery Awards. The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease. 🔗Full story: bit.ly/4oW3D99 @astburycentre.bsky.social @universityofleeds.bsky.social

Our review article on recent RNase H2 in replciation stress and cancer has been published in @jcellsci.bsky.social! Thank you for the invitation Journal of Cell Science @jcellsci.bsky.social and Company of Biologists @biologists.bsky.social. journals.biologists.com/jcs/article/...

Our @costerlab.bsky.social review is out! It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course! www.sciencedirect.com/science/arti... @adityasethi.bsky.social @billiedelpino.bsky.social

🎉 Congrats to the faculty's Dr Jonathan Machin who has been awarded the British Biophysical Society's 2026 Kendrew Doctoral Thesis Prize, for his outstanding research on outer membrane proteins. Read more here: britishbiophysics.org/awards/

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation??? Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)

The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.

📢 Last days to apply! 📢 Fully funded PhD position, starting Oct 2026. Deadline Nov 16th. We provide a supportive environment and top notch facilities, helping you develop into an independent scientist. Project details: tinyurl.com/CosterPhD Apply: tinyurl.com/ApplyICR The lab: CosterLab.com

Join us in a highly collaborative environment. At the IMP everything is possible.

Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects. If you’re at the conference, come say hi before it wraps up!! 👋

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!

Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD! Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!

If you are working on Genome stability and repair pathways and you're looking for a tenure track professorship, check out this opportunity at The Max Perutz Labs at the University of Vienna: jobs.zeit.de/jobs/tenure-...

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries lnkd.in/etU3yydb

Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Xingzhi Xu, Shunichi Takeda and collaborators show that UFL1-dependent #UFMylation of MCM5 promotes CMG replicative helicase formation and replication fork progression www.embopress.org/doi/full/10....

🔬 What are plasmodesmata, and why are they important? In this new case study, discover how the Faculty's Professor Yoselin Benitez-Alfonso's research into microscopic plant pores could help tackle climate change and global food insecurity. bit.ly/4pocNvX @researchleeds.bsky.social

Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.

Looking forward to another great day at Ribosome biogenesis meeting @embo.org Great conversations yesterday and lively to catch up with colleagues!

We’re happy to share that our labs first #ALS and #FTD study “A stress-dependent TDP-43 SUMOylation program preserves neuronal function” is now online at Molecular Neurodegeneration! doi.org/10.1186/s130...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path. rdcu.be/eDzPk

Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function. www.cell.com/cell-chemica...

What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation #RefereedPreprint c/o @reviewcommons.org www.embopress.org/doi/full/10....

Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!

We are happy to have contributed a protocol to a book on SUMO methods (work mainly by postdoc El Hadji Cisse and engineer Stéphane Goffinont): link.springer.com/protocol/10....

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Opening a "Decision on your Manuscript" email

Happy to share that my first-author paper from my postdoc at Imperial @imperialcollegeldn.bsky.social and The Francis Crick Institute @crick.ac.uk is now published in Cell Reports! www.sciencedirect.com/science/arti...

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

Very happy to see this one out from @themorrislab.bsky.social. It turns out that the SUMO E1 enzyme can discriminate between SUMO isoforms by using an acetylation/deacetylation switch during mitosis. www.embopress.org/doi/full/10....

Amazing efforts from first author @francescachandler.bsky.social and collaborators Roger Greenberg, Joseph Salvino, Francesco Del Galdo and their teams. @pennmedicine.bsky.social @wistar.org @astburycentre.bsky.social @astbury-bsl.bsky.social @antoncalabrese.bsky.social @bioscienceleeds.bsky.social

Aspiring PhD students, this is your chance to join us at the NKI to work on genomic instability and telomeres!: www.werkenbijavl.nl/vacatures/ph...

Research that could change lives: A new paper led by Leeds researchers shows DNA by-products may be 'early warning system' for relapse in childhood leukaemia. Read it in Nature: bit.ly/41zW927 @cclguk.bsky.social @littleprincesses.bsky.social @bloodcanceruk.bsky.social @ljrusselllab.bsky.social

🚨 We’re hiring! 🚨 We’re looking for a Correlative Imaging Scientist to join our EM team at ABSL! You will be developing and supporting cryo-EM & cryo-CLEM workflows across multiple imaging platforms (FIB-SEM, cryo-confocal, cryo-EM). Any questions? Get in touch! jobs.leeds.ac.uk/Vacancy.aspx...

Great paper by the Vaziri lab about the role of RNF25 regulating the DDR independently of its E3 ligase activity! www.nature.com/articles/s41...

Interesting: Cu2+-binding sites on SUMO connecting multiple SUMOs together.

We are still accepting abstracts for selected short talks and posters. The abstract deadline has been extended to this Friday, 1st Aug. More information and registration here: www.lorneubiquitin.org .