Still time to register to join us next Friday in Leeds for our annual in-person UK Cilia and Centrosome Network in Leeds (05/06/2026)! Keynotes from the amazing @helenfoster.bsky.social & Fanni Gergely, plus latest breaking #cilia & #centrosome science. Register: www.eventbrite.co.uk/e/uk-cilia-c...

Over the past 5 years, 50 structures of full-length HECT-type ligase constructs have been deposited in the PDB. What have we learned from these studies, and what key questions remain open? Check out our new review on this exciting and fast-moving field: www.jbc.org/article/S002...

How mavacamten inhibits myosin to alleviate inherited heart disease revealed using cryoEM @snmcmillan.bsky.social and qXL-MS @jaimedoesxlms.bsky.social brilliant collaborative effort!! www.science.org/doi/10.1126/...

Now online! Lovely work by Vanda Gunning et al. "Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction" Collaboration between labs of @molecularrichard.bsky.social, Eileen Kennedy and me. authors.elsevier.com/sd/article/S...

🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp

🚨 Our new paper is out! 🙌 Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs. We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs. www.cell.com/chem/fulltex... 1/4

Online Now: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Online now:

The Royal Society's Newton International Fellowships are now open for applications, aimed at non-UK early career scientists who wish to conduct research in the UK. Find out more and apply by 11 March: #RSGrants https://royalsociety.org/grants/newton-international/

The final version of our article on XPF-ERCC1-SLX4 complexes has now been published (the link below still works). I am happy to report that the rendering of our DNA gels has now been corrected. 😉

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Excited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...

Check out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...

Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling link.springer.com/article/10.1...

New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks. www.sciencedirect.com/science/arti...

Congratulations to the 2025 Policy Impact and Public Engagement Awards winners! 🎉 Meet them at www.nottingham.ac.uk/policyengage... #WeAreUoN

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated! www.biorxiv.org/content/10.6...

Deadline to apply for MRC fully funded 4-year PhD studentships is approaching on *9 Jan 2026*! Join world-class researchers across @unibirmingham.bsky.social , @uniofleicester.bsky.social and @uniofnottingham.bsky.social 👉See more.bham.ac.uk/mrc-aim/phd-...

Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

Leeds researchers have secured two major Wellcome Trust Discovery Awards. The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease. 🔗Full story: bit.ly/4oW3D99 @astburycentre.bsky.social @universityofleeds.bsky.social

Our review article on recent RNase H2 in replciation stress and cancer has been published in @jcellsci.bsky.social! Thank you for the invitation Journal of Cell Science @jcellsci.bsky.social and Company of Biologists @biologists.bsky.social. journals.biologists.com/jcs/article/...

Our @costerlab.bsky.social review is out! It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course! www.sciencedirect.com/science/arti... @adityasethi.bsky.social @billiedelpino.bsky.social

🎉 Congrats to the faculty's Dr Jonathan Machin who has been awarded the British Biophysical Society's 2026 Kendrew Doctoral Thesis Prize, for his outstanding research on outer membrane proteins. Read more here: britishbiophysics.org/awards/

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation??? Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)

The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.

📢 Last days to apply! 📢 Fully funded PhD position, starting Oct 2026. Deadline Nov 16th. We provide a supportive environment and top notch facilities, helping you develop into an independent scientist. Project details: tinyurl.com/CosterPhD Apply: tinyurl.com/ApplyICR The lab: CosterLab.com

Join us in a highly collaborative environment. At the IMP everything is possible.

Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects. If you’re at the conference, come say hi before it wraps up!! 👋

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!

Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD! Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!

If you are working on Genome stability and repair pathways and you're looking for a tenure track professorship, check out this opportunity at The Max Perutz Labs at the University of Vienna: jobs.zeit.de/jobs/tenure-...

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries lnkd.in/etU3yydb

Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Xingzhi Xu, Shunichi Takeda and collaborators show that UFL1-dependent #UFMylation of MCM5 promotes CMG replicative helicase formation and replication fork progression www.embopress.org/doi/full/10....

🔬 What are plasmodesmata, and why are they important? In this new case study, discover how the Faculty's Professor Yoselin Benitez-Alfonso's research into microscopic plant pores could help tackle climate change and global food insecurity. bit.ly/4pocNvX @researchleeds.bsky.social

Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.

Looking forward to another great day at Ribosome biogenesis meeting @embo.org Great conversations yesterday and lively to catch up with colleagues!

We’re happy to share that our labs first #ALS and #FTD study “A stress-dependent TDP-43 SUMOylation program preserves neuronal function” is now online at Molecular Neurodegeneration! doi.org/10.1186/s130...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path. rdcu.be/eDzPk

Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function. www.cell.com/cell-chemica...