The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...

O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells #NatCommun #MassSpec www.nature.com/articles/s41...

Nature Communications is looking to hire an organic chemist – more details in the link below #Chemsky #Chemjobs 🧪

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! www.nature.com/articles/s41...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

🌱 Thrilled to share that our latest research on Vacuolar Quality Control is now published in Nature Plants! 🚀 We uncovered a new mechanism of ATG8ylation of the tonoplast, which helps us understand how cells survive to cell wall damage. Check it out here: www.nature.com/articles/s41...

Hold this date for the 2nd UK Proteostasis Network in Dundee👉🏾 3-5 June 2025. This will be a joint meeting with the UK Autophagy network. More info coming soon proteostasisuk.co.uk/conference-2... @ukproteostasis.bsky.social

How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR & NV shorturl.at/fImjA

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control #NatCommun www.nature.com/articles/s41...

A majority of eukaryotic proteins are N-terminally acetylated. Here is an updated review of the responsible enzymes and the impact of this modification for proteins, cells and organisms @naturecomms.bsky.social @ispt-proteinterm.bsky.social #acetylation #N-termini #N-degron rdcu.be/d6mbd

Tell me they are growing up with cats without telling me that they are growing up with cats…

Our call for papers with @naturecomms.bsky.social, Communications Chemistry & Scientific Reports welcomes manuscripts exploring glycans in the broadest sense, seeking basic, translational, and applied glycobiology research: www.nature.com/collections/... 🧪

Paper of interest for the #CryoET folks. www.nature.com/articles/s41...

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination www.nature.com/articles/s41...