Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...

The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...

O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells #NatCommun #MassSpec www.nature.com/articles/s41...

Nature Communications is looking to hire an organic chemist – more details in the link below #Chemsky #Chemjobs 🧪

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies! www.nature.com/articles/s41...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

🌱 Thrilled to share that our latest research on Vacuolar Quality Control is now published in Nature Plants! 🚀 We uncovered a new mechanism of ATG8ylation of the tonoplast, which helps us understand how cells survive to cell wall damage. Check it out here: www.nature.com/articles/s41...

Hold this date for the 2nd UK Proteostasis Network in Dundee👉🏾 3-5 June 2025. This will be a joint meeting with the UK Autophagy network. More info coming soon proteostasisuk.co.uk/conference-2... @ukproteostasis.bsky.social

How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR & NV shorturl.at/fImjA

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control #NatCommun www.nature.com/articles/s41...

A majority of eukaryotic proteins are N-terminally acetylated. Here is an updated review of the responsible enzymes and the impact of this modification for proteins, cells and organisms @naturecomms.bsky.social @ispt-proteinterm.bsky.social #acetylation #N-termini #N-degron rdcu.be/d6mbd

Tell me they are growing up with cats without telling me that they are growing up with cats…

Our call for papers with @naturecomms.bsky.social, Communications Chemistry & Scientific Reports welcomes manuscripts exploring glycans in the broadest sense, seeking basic, translational, and applied glycobiology research: www.nature.com/collections/... 🧪

Paper of interest for the #CryoET folks. www.nature.com/articles/s41...

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination www.nature.com/articles/s41...