Paulo Ribeiro, @aashikasekar.bsky.social et al @qmbci.bsky.social find that protein phosphatase PP2A activates the Hippo pathway in Drosophila, in addition to its role as a Hippo negative regulator as part of the STRIPAK complex link.springer.com/article/10.1...

‘Big changes’: Crick to stop paying for hybrid open access. www.researchprofessionalnews.com/rr-news-uk-o...

Nigel Farage’s Brexit rallies were funded from the EU budget European monies paid for anti-immigrant posters during ‘Say No to EU’ tour archive.fo/DtTsn

Multispecific T-cell engagers attract cancer drug developers nature.com/articles/d41... Multispecific T-cell engagers that bind three or more targets on cancer and immune cells promise to address the shortcomings of their bispecific predecessors

As ministers and the media ponder how to increase spending on defence, Ltd worth reminding ourselves that were it not for the damage Brexit has inflicted on us, we would t be having this conversation. Farage and Johnson have screwed us all.

Mariana Mazzucato has gone viral after calling Brexit “a crime,” arguing that Britain has underinvested by £500 billion compared with OECD averages and that Nigel Farage and Boris Johnson have never really been held accountable.

I won't pay $4,000 for a ticket to see my Knicks play in the NBA Finals for the first time in 27 years, but for some reason I routinely pay three times that much for open access to papers that I wrote myself.

My homeland is leading the world right now.

@embopress.org is glad to support the #TrustSeal initiative to become an objective & transparent tool for the community, funders & research assessment to see which of the 35k+ biomed science journals to support. TX for taking the lead @faseborg.bsky.social & biocore.com @embo.org hubs.ly/Q04j1D500

Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis Ikuo Suzuki and coworkers link.springer.com/article/10.1...

One-step generation of T-cell receptor knock-in mice in the TCRβ locus – new methods paper by Angelina Bilate, Johanne Jacobsen and coworkers! link.springer.com/article/10.1...

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

So delighted to have been part of this fantastic collaboration spearheaded by Ngee Kiat 'Jake' Chua (蔡毅杰) and Rebecca Feltham! Congratulations on bringing together so many experts in the field to make such an important resource 🎉 it has been a pleasure! www.sciencedirect.com/science/arti...

Our work on the E3 ligase mechanism of target-directed microRNA degradation is now published! Amazing collaboration with Brenda Schulman’s lab led by @jakobfarnung.bsky.social and @elenaslo.bsky.social, with special thanks to @wyppeter.bsky.social, Lianne Blodgett, and Daniel Lin! tinyurl.com/Z8TDMD

The second day of #Biochemistry2026 gets on the way with an exciting talk by Satpal Virdee (@e3chembio.bsky.social). "Next-generation Activity-Based Probes for Ubiquitin and Ubiquitin-like E3 Ligases". www.nature.com/articles/nch... #ChemBio #Biochemistry #ChemSky #ubiquitin #TPD #degradation

Paused MRC funding calls to restart earlier than expected. Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure. www.researchprofessionalnews.com/rr-news-uk-r...

Many genome-editing tools work by cutting DNA - but the shape of the cut matters. Using genome-wide screening, we show ERCC6L2 is specifically required to maintain repair fidelity at staggered DNA breaks, but not at blunt ends. www.nature.com/articles/s41...

UK university unions demand pay rise 3% above inflation Employers describe claim as “extremely challenging” in current financial climate www.researchprofessionalnews.com/rr-news-uk-u...

Elsevier rejections: libraries ‘had to make cuts somewhere’. Experts say publisher’s pricing and profits are likely factors in rejection by some universities. www.researchprofessionalnews.com/rr-news-uk-o...

Redundancies at research-intensive universities double in two years. www.researchprofessionalnews.com/rr-news-uk-u...

Another great science appointment is coming up with @centromellone.bsky.social, Michele Pagano and Gergely Róna! Join us live on Tuesday, March 3rd at 5pm (Rome) / 11am (NYC). Zoom link: uniroma1.zoom.us/j/95149984403 Register here to stay in the loop: docs.google.com/forms/d/e/1F...

Job losses at UK research-intensive universities double in two years. Exclusive: Scale of redundancies branded a “disaster”. www.researchprofessionalnews.com/rr-news-uk-u...

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

www.bbc.com/news/article... interesting

📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’ 📅22-25 June 2026 📍CRUK Scotland Institute, Glasgow 🎟️Early Bird registration closes on 1 April 🔗 www.beatsonconference.org #BICC2026 #CancerResearch #Immunology

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief By Islam et al., and Luca Busino ➡️ https://genesdev.cshlp.org/content/early/2025/12/08/gad.352916.125.abstract #PROTAC #KRAS #cancer #cancertherapy

Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community! We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.

Cara Maria Carmela Masi, desidero ringraziarti per la menzione: www.ecodicaserta.it/notizie/cult.... Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.

Three UK research councils suspend funding opportunities “Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts”

Or: Scientists are furious that they are learning of pauses to their main access to funding through press snippets rather than first hand dialogue with Uni research offices………..

Nature's Impact Factor is in the Epstein Files. Really.

That would be catastrophic

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

SS18::SSX activates Polycomb target genes without BAF ❌ Instead, transcription relies on EP300 via the SS18 QPGY domain www.biorxiv.org/content/10.6... ➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯 Team work from @banitolab.bsky.social and @uoe-igc.bsky.social

Academic publishing is now one of the most lucrative industries per unit of input theconversation.com/when-science...

Am spending my Saturday reading grant proposals and feeling such pessimism about the state of uk science funding. So many good ideas, so many talented researchers, so incredibly little investment 😞

Leeds researchers have secured two major Wellcome Trust Discovery Awards. The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease. 🔗Full story: bit.ly/4oW3D99 @astburycentre.bsky.social @universityofleeds.bsky.social

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...

Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling link.springer.com/article/10.1...

Cara Maria Carmela Masi, desidero ringraziarti per la menzione: www.ecodicaserta.it/notizie/cult.... Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.

In 2025, we reviewed a new lab record number of 117 manuscripts. If I was to charge 250 EUR per hour and would invest 2 h of work for every review this would make 58500 EUR @springernature.com @elsevierconnect.bsky.social @embopress.org & Co. owe me and my junior co-reviewers... Happy Sunday!

Happening now! #MeetTheEditors #CellBio2025

Induced proximity-based therapeutic modalities nature.com/articles/s41... rdcu.be/eOfBH This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more

How can we find out what’s really going on inside cells when we’re generating so much complex data? CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact. www.ebi.ac.uk/about/news/r... 🧪

Research Saves Lives At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc. Check it out: researchsaveslives.jhu.edu

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s! @natsmb.nature.com 1/7 www.nature.com/articles/s41...