One-step generation of T-cell receptor knock-in mice in the TCRβ locus – new methods paper by Angelina Bilate, Johanne Jacobsen and coworkers! link.springer.com/article/10.1...

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

So delighted to have been part of this fantastic collaboration spearheaded by Ngee Kiat 'Jake' Chua (蔡毅杰) and Rebecca Feltham! Congratulations on bringing together so many experts in the field to make such an important resource 🎉 it has been a pleasure! www.sciencedirect.com/science/arti...

Our work on the E3 ligase mechanism of target-directed microRNA degradation is now published! Amazing collaboration with Brenda Schulman’s lab led by @jakobfarnung.bsky.social and @elenaslo.bsky.social, with special thanks to @wyppeter.bsky.social, Lianne Blodgett, and Daniel Lin! tinyurl.com/Z8TDMD

The second day of #Biochemistry2026 gets on the way with an exciting talk by Satpal Virdee (@e3chembio.bsky.social). "Next-generation Activity-Based Probes for Ubiquitin and Ubiquitin-like E3 Ligases". www.nature.com/articles/nch... #ChemBio #Biochemistry #ChemSky #ubiquitin #TPD #degradation

Paused MRC funding calls to restart earlier than expected. Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure. www.researchprofessionalnews.com/rr-news-uk-r...

Many genome-editing tools work by cutting DNA - but the shape of the cut matters. Using genome-wide screening, we show ERCC6L2 is specifically required to maintain repair fidelity at staggered DNA breaks, but not at blunt ends. www.nature.com/articles/s41...

UK university unions demand pay rise 3% above inflation Employers describe claim as “extremely challenging” in current financial climate www.researchprofessionalnews.com/rr-news-uk-u...

Elsevier rejections: libraries ‘had to make cuts somewhere’. Experts say publisher’s pricing and profits are likely factors in rejection by some universities. www.researchprofessionalnews.com/rr-news-uk-o...

Redundancies at research-intensive universities double in two years. www.researchprofessionalnews.com/rr-news-uk-u...

Another great science appointment is coming up with @centromellone.bsky.social, Michele Pagano and Gergely Róna! Join us live on Tuesday, March 3rd at 5pm (Rome) / 11am (NYC). Zoom link: uniroma1.zoom.us/j/95149984403 Register here to stay in the loop: docs.google.com/forms/d/e/1F...

Job losses at UK research-intensive universities double in two years. Exclusive: Scale of redundancies branded a “disaster”. www.researchprofessionalnews.com/rr-news-uk-u...

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

www.bbc.com/news/article... interesting

📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’ 📅22-25 June 2026 📍CRUK Scotland Institute, Glasgow 🎟️Early Bird registration closes on 1 April 🔗 www.beatsonconference.org #BICC2026 #CancerResearch #Immunology

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief By Islam et al., and Luca Busino ➡️ https://genesdev.cshlp.org/content/early/2025/12/08/gad.352916.125.abstract #PROTAC #KRAS #cancer #cancertherapy

Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community! We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.

Cara Maria Carmela Masi, desidero ringraziarti per la menzione: www.ecodicaserta.it/notizie/cult.... Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.

Three UK research councils suspend funding opportunities “Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts”

Or: Scientists are furious that they are learning of pauses to their main access to funding through press snippets rather than first hand dialogue with Uni research offices………..

Nature's Impact Factor is in the Epstein Files. Really.

That would be catastrophic

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

SS18::SSX activates Polycomb target genes without BAF ❌ Instead, transcription relies on EP300 via the SS18 QPGY domain www.biorxiv.org/content/10.6... ➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯 Team work from @banitolab.bsky.social and @uoe-igc.bsky.social

Academic publishing is now one of the most lucrative industries per unit of input theconversation.com/when-science...

Am spending my Saturday reading grant proposals and feeling such pessimism about the state of uk science funding. So many good ideas, so many talented researchers, so incredibly little investment 😞

Leeds researchers have secured two major Wellcome Trust Discovery Awards. The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease. 🔗Full story: bit.ly/4oW3D99 @astburycentre.bsky.social @universityofleeds.bsky.social

I have a PhD position available with start date September 2026 at the University of Manchester. Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes Due to funding requirements, this position is for UK home students only. www.findaphd.com/phds/project...

Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...

Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling link.springer.com/article/10.1...

Cara Maria Carmela Masi, desidero ringraziarti per la menzione: www.ecodicaserta.it/notizie/cult.... Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.

In 2025, we reviewed a new lab record number of 117 manuscripts. If I was to charge 250 EUR per hour and would invest 2 h of work for every review this would make 58500 EUR @springernature.com @elsevierconnect.bsky.social @embopress.org & Co. owe me and my junior co-reviewers... Happy Sunday!

Happening now! #MeetTheEditors #CellBio2025

Induced proximity-based therapeutic modalities nature.com/articles/s41... rdcu.be/eOfBH This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more

How can we find out what’s really going on inside cells when we’re generating so much complex data? CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact. www.ebi.ac.uk/about/news/r... 🧪

Research Saves Lives At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc. Check it out: researchsaveslives.jhu.edu

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s! @natsmb.nature.com 1/7 www.nature.com/articles/s41...

On #InternationalOvarianCancerDay, we held a Shining a Light on Ovarian Cancer event where Professor Charlie Gourley, Dr Rob Hollis and Dr Sarah Taylor talked about how their research is driving personalised patient care & BBC journalist Christine Macleod shared her story of going through treatment.

🧬 New Research Alert! 🧬 "Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase" www.biorxiv.org/content/10.1... Our findings reveal that Fbxo42 main function is to control PP4 phosphatase. Discussions are highly welcome! #bioRxiv #Research #Science #ubiquitin

🧬 New Research Alert! 🧬 "Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase" www.biorxiv.org/content/10.1... Our findings reveal that Fbxo42 main function is to control PP4 phosphatase. Discussions are highly welcome! #bioRxiv #Research #Science #ubiquitin

PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻 A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet Brainchild of the amazing #GeneKoh (Sir Jeffrey Cheah ECR) Tweetorial below!! 👇 1/n www.nature.com/articles/s41...

Stunning images from Francis Barr’s lab have won CRUK’s Research is Beautiful competition for February! 🌟 They capture microtubules connecting to chromosomes via kinetochores to create mitotic spindles. 🔬✨ news.cancerresearchuk.org/2025/03/13/l... @oxfordbiochemistry.bsky.social

Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!

The irony of an article discussing the unpaid labor of scientists, published by a $4bn corporation reliant on the unpaid labor of scientists. Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today #academicSky #medSky #research

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher @durocher1.bsky.social and many others. www.biorxiv.org/content/10.1...

Thanks to the many collaborators; the labs of Thijn Brummelkamp, Alexander van Oudenaarden, Steven de Jong, Frank Sicheri, Marvin Tanenbaum @marvintanenbaum.bsky.social @jervdberg.bsky.social @rinskjetjeerdsma.bsky.social @mauritsroorda.bsky.social @daaninthelab.bsky.social

Help 🚨 science Bluesky. We'd like an #GFP/#FluorescentProtein construct with an intron in the middle of the coding sequence for an experiment (not before the coding sequence). Does anyone know of anything that fits? We haven't turned up anything suitable from a quick search so far. Please repost 🙏