In 2025, we reviewed a new lab record number of 117 manuscripts. If I was to charge 250 EUR per hour and would invest 2 h of work for every review this would make 58500 EUR @springernature.com @elsevierconnect.bsky.social @embopress.org & Co. owe me and my junior co-reviewers... Happy Sunday!

Happening now! #MeetTheEditors #CellBio2025

Induced proximity-based therapeutic modalities nature.com/articles/s41... rdcu.be/eOfBH This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more

How can we find out what’s really going on inside cells when we’re generating so much complex data? CORNETO is an open-source tool that uses machine learning to turn tangled omics datasets into clear maps of how genes, proteins, and signalling pathways interact. www.ebi.ac.uk/about/news/r... 🧪

Research Saves Lives At Hopkins, we just went live with an expansive website showing the extraordinary value of research, the impact of cuts to research, what's at stake, resources for our research community, etc. Check it out: researchsaveslives.jhu.edu

Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s! @natsmb.nature.com 1/7 www.nature.com/articles/s41...

On #InternationalOvarianCancerDay, we held a Shining a Light on Ovarian Cancer event where Professor Charlie Gourley, Dr Rob Hollis and Dr Sarah Taylor talked about how their research is driving personalised patient care & BBC journalist Christine Macleod shared her story of going through treatment.

🧬 New Research Alert! 🧬 "Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase" www.biorxiv.org/content/10.1... Our findings reveal that Fbxo42 main function is to control PP4 phosphatase. Discussions are highly welcome! #bioRxiv #Research #Science #ubiquitin

🧬 New Research Alert! 🧬 "Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase" www.biorxiv.org/content/10.1... Our findings reveal that Fbxo42 main function is to control PP4 phosphatase. Discussions are highly welcome! #bioRxiv #Research #Science #ubiquitin

PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻 A redefined InDel taxonomy provides insights into mutational signatures @NatureGenet Brainchild of the amazing #GeneKoh (Sir Jeffrey Cheah ECR) Tweetorial below!! 👇 1/n www.nature.com/articles/s41...

Stunning images from Francis Barr’s lab have won CRUK’s Research is Beautiful competition for February! 🌟 They capture microtubules connecting to chromosomes via kinetochores to create mitotic spindles. 🔬✨ news.cancerresearchuk.org/2025/03/13/l... @oxfordbiochemistry.bsky.social

Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!

The irony of an article discussing the unpaid labor of scientists, published by a $4bn corporation reliant on the unpaid labor of scientists. Meanwhile RJmedicine.org, a journal in which we offer $ honoraria to authors and reviewers, opened for submissions today #academicSky #medSky #research

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher @durocher1.bsky.social and many others. www.biorxiv.org/content/10.1...

Thanks to the many collaborators; the labs of Thijn Brummelkamp, Alexander van Oudenaarden, Steven de Jong, Frank Sicheri, Marvin Tanenbaum @marvintanenbaum.bsky.social @jervdberg.bsky.social @rinskjetjeerdsma.bsky.social @mauritsroorda.bsky.social @daaninthelab.bsky.social

Help 🚨 science Bluesky. We'd like an #GFP/#FluorescentProtein construct with an intron in the middle of the coding sequence for an experiment (not before the coding sequence). Does anyone know of anything that fits? We haven't turned up anything suitable from a quick search so far. Please repost 🙏

Interesting idea: get the sick super-rich to pay for clinical trials Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....) www.theguardian.com/news/2025/ma...

This is why UK gov needs to invest in PhD training & cut visa costs for scientists Long term economic growth depends on skilled people The UK should make the most of life sciences

I know there is not a lot of love for X on this platform but please think about Ivano's @ivanoamelio.bsky.social words www.nature.com/articles/d41...

March is #OvarianCancerAwarenessMonth. IGC researchers are leading significant advancements in our understanding of the disease. Dr Robb Hollis has written about work being undertaken at the Nicola Murray Centre for Ovarian Cancer Research into uncommon types of ovarian cancer: edin.ac/4jBEcId

Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by @scientistkate.bsky.social, with her co-supervisor @piptaberlay.bsky.social and collaborator Mat Jones. www.frontiersin.org/journals/cel...

Happy that I got to handle and help publish this cool new work for @embojournal.org And after many years of PARPi/(poly-ADP)ribose craze, exciting to see mono-ADP-ribosylation starting to reveal its secrets in so many ways now!

📢 Don’t miss our next Cancer Biology and Medicine talk tomorrow! The role of transcription factors in cancer Prof Jason Carroll, @cruk-ci.bsky.social Thurs 20 Feb, 9:30-10:30 WH lecture theatre, School of Clinical Medicine All welcome @cambridge-scm.bsky.social

Correlation Vs. Causation

Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find! www.nature.com/articles/s41...

Very happy to have participated to this fantastic work by Brian Liau and Ning Zheng, which sheds an electron microscopy light on the mechanism of KBTBD4 mutant recognition of CoRest. Substrate diversification of E3s by mutations: www.nature.com/articles/s41...

Lovely lab lunch with this amazing bunch of cancer researchers @uofgcancersciences.bsky.social @cruk-si.bsky.social @scs-voice.bsky.social #womeninscience

Brilliant work by Jacob Corn and Jeffrey Bode. Another example of neosubstrate recruitment by E3s similar to KBTBD4 nromorphic cancer mutation www.nature.com/articles/s41...

Yann LeCun, leader of A.I. at Meta. “China is beating the United States at A.I.” is misreading the situation The correct reading is: ‘Open source models are surpassing proprietary ones, and because their work is published and open source, everyone can profit from it.” www.nytimes.com/2025/01/29/t...

DIA-NN 2.0 is released! We consider it the biggest step forward in the history of DIA-NN. On modern LC-MS almost all identifications are now peptidoform-confident, with major improvements e.g. for phospho. Some other cool things too: github.com/vdemichev/Di...

How did Cell, Nature & Science become the 3 hottest journals in biomedical research? You could call it 'The Curious Case of Benjamin Lewin’ & it's told in today's episode of the Night Science podcast with Keith Yamamoto (@kryamamoto.bsky.social ; starts at 15:00) @nightsciencepod.bsky.social ⬇️

Our paper “A genome-wide atlas of human cell morphology” is finally out today in @naturemethods.bsky.social ! www.nature.com/articles/s41... (I tweeted about our preprint in 2023 over at the bad place, but deactivated my account, so here we go again!)

I agree on this perspective on EMT. Probably also tissues of origin of cancer are important both in pathogenesis and treatment (including immune stimulation). cellandbioscience.biomedcentral.com/articles/10....

⛔Cell Cycle, Checkpoint and Cancer... Learn more about the PhD project in Laboratory of Cancer Cell Biology 👉http://img.cas.cz/phd Join us, we are waiting for you! Your future starts now! #phd #phdstudent #science #openpositions #phdcommunity #prague 📸Radka Storchova

In this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q! Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization. A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.

Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...

Finally the structure of cyclin F !!!! Brilliant work by Seth Rubin and Mike Emanuele : www.biorxiv.org/content/10.1...

Apply as Transition Fellow in Brain Tumour Research @edinburghuni.bsky.social and @ucl.ac.uk ! 📢 Develop your independent research programme 💡 Collaborate with world-class experts for info contact Steven Pollard, Simona Parrinello, Vincenzo D'Angiolella #ResearchJobs #BrainCancer #CareerOpportunity

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage @naturecellbiology.bsky.social @szmyd-radoslaw.bsky.social @thecesarelab.bsky.social @radoncdocgee.bsky.social www.nature.com/articles/s41...

Apply as Transition Fellow in Brain Tumour Research @edinburghuni.bsky.social and @ucl.ac.uk ! 📢 Develop your independent research programme 💡 Collaborate with world-class experts for info contact Steven Pollard, Simona Parrinello, Vincenzo D'Angiolella #ResearchJobs #BrainCancer #CareerOpportunity

In this Review, Tao et al. discuss the origins and heterogeneity of pediatric medulloblastoma, through the molecular lens of cerebellar development, for the advancement of disease modeling, treatment and outcomes. #OpenAccess Learn more here: ➡️ tinyurl.com/gd351936

My research is finally out! Huge thanks to @thecesarelab.bsky.social, @radoncdocgee.bsky.social, and everyone involved for their invaluable support along the way. Briefly, we have demonstrated that cell cycle dependent DSB repair pathways guide death outcomes following lethal genomic damage.

I am thrilled to finally share our work on persister cancer cells: we identify distinctive features and actionable #vulnerabilities ⚡️of persister cancer cells (#DTP), and provide mechanistic insight into their low #inflammatory activity: aacrjournals.org/cancerres/ar...

Our new paper showing how loss of the nuclear pore protein TPR leads to activation of an inflammatory gene expression programme in senescence is now published in eLife: bit.ly/4h1VcFi @wbickmor.bsky.social @uoe-igc.bsky.social @elife.bsky.social

Collaboration with @supertifurgalab.bsky.social out in @cp-cellchembiol.bsky.social we identify a role of ABCC1 transporter in PROTAC efflux. It turns out, getting in is surprisingly not often the problem; it’s keeping it once inside the cell! Maybe some wider lessons. Designing it out could be key