Just published in Nat. Neurosci. Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression. @erzimmer.bsky.social @natureportfolio.nature.com www.nature.com/articles/s41...

I did not expect that: Large Language Models are invertible: arxiv.org/abs/2510.15511

Daniel Abbühl, Philippe Bastin @bastinlab.bsky.social and colleagues use a novel approach for tagging tubulin to dissect microtubule assembly dynamics of the axoneme in Trypanosoma brucei. #JCSciliaSI journals.biologists.com/jcs/article/...

PhD project available in my lab. Email me with CV if interested www.findaphd.com/phds/project... #microsky #bioimaging

Neat - 'bubble-driven cell detachment' from Kripa Varanasi and co. doi.org/10.1126/scia...

Intéressant, ça : les critères de sélection du prochain Scientifique en chef du Québec ont été publiés cette semaine. Des volontaires ? 😉 publicationsduquebec.gouv.qc.ca/fileadmin/ga...

I never thought watching microtubules break could be so interesting! I learned so much about mechanics and modeling in this work and am extremely grateful to Archie Geng for leading the way. Also huge thanks to François Nédélec for creating Cytosim and providing advice along the way.

"Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue," NatBME doi.org/10.1038/s41551-025-01496-4 A culmination of wild brainstorms, imaging marathons, analysis breakthroughs and setbacks, around the clock work before conferences, and new friends along the way! 🧠🎆

The culmination of many years work. One of the most advanced light-sheet microscopes in the world! -> A large field of view Snouty light-sheet microscope, with any immersion remote refocus and real-time multi-angle projections! For details see previous posts and here: github.com/amsikking/HT...

RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders. Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others! Check it out: lnkd.in/eiUFfJaM.

KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia: Current Biology www.cell.com/current-biol...

Examining measures of executive function & MRI brain data from 497 252 UK Biobank cases, researchers find that pre-diagnosis MRI grey matter volume was lower in #Parkinsons (vs controls), in addition to curious trends in other disease indications academic.oup.com/braincomms/a...

New article online: Ångström-tunable polarization-resolved solid-state photon sources. go.nature.com/4gdVWYR

Reconstructing long-range axons from dense brain images is tough. This study introduces a novel method that separates axon identification from global statistical rules, showing big improvements over existing tools for mapping neuronal projections. buff.ly/OBKr9cM

New article online: Extreme-ultraviolet spatiotemporal vortices via high harmonic generation. go.nature.com/4m0Tc2e

Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.

YO, what's up with all these almost-witchcraft techniques?? In this paper, they develop a way to freeze cells so quickly that it preserves Calcium waves midway!! WHAT??? HELLO??? So now you can do 3D reconstruction of calcium waves with just a normal confocal. www.nature.com/articles/s41...

🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods! 📦 Ultrack — robust, scalable nD cell tracking 🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration Let’s dive in! 👇 www.nature.com/articles/s41... www.nature.com/articles/s41...

There is still time to apply to become part of our team at Nature Biomedical Engineering! Please share! springernature.wd3.myworkdayjobs.com/SpringerNatu...

Can we learn motion models from post-processed tracks? 🧐 Not really 😢 Emission noise accounts for ~99% of the likelihood. TLDR: What you think is anomalous diffusion… might just be noise. 🤷‍♂️🤷‍♂️🤷‍♂️🤷‍♂️ 🔗 Read more in our latest preprint: arxiv.org/abs/2507.05599 #Biophysics

It's out & hot 🔥 Not only because it just went online but since we show that engineered heat patterns are super effective in manipulating fluid flows & particles. If you work in microfluidics, or need reconfigurable environments in your experiments, give it a read! www.nature.com/articles/s41... 🧪💡

New open access article online: Microscale generation and control of nanosecond light by light in a liquid crystal. go.nature.com/3H0mT5a

Super-resolution live-cell mapping of protein-protein interactions using chemogenetic split reporters and STED microscopy https://www.biorxiv.org/content/10.1101/2025.08.05.668682v1

#PALH: How to convert a #3Dprinter to a personal #automated #OpenSource #liquid #handler for life #science workflows: - based on #Ender3 - cost: US $400 - #PCR setup, #DNA purification using #magnetic beads doi.org/10.1016/j.sl... #DIYbio #DIYchem #chemistry #lab #instruments #pipet #automation

Wyss scientists have invented a novel metabolic labeling technology that enables the “tagging” of the surface of T cells with immune-enhancing cytokine molecules, which could help expand adoptive T cell therapies to the treatment of solid tumors.

Ångström-resolution imaging of cell-surface glycans Now published in Nature Nanotechnology! 🤩 @natnano.nature.com www.nature.com/articles/s41...

Pieces of the puzzle coming together: Researchers report #Parkinsons-associated GBA1 mutations impair Sonic Hedgehog signaling & Hedgehog-dependent neuroprotective factor production by a distinct mechanism www.pnas.org/doi/10.1073/...

Tensorstore is much faster for read/write than vanilla zarr. Tools are here: github.com/QI2lab/opm-p... Currently we only support our custom pymmcore-plus OPM format and ASI’s OPM format. Happy to work with you to support CZI LLSM files if you open an issue and provide some example data.

🎉Just out in @chemcomm.rsc.org! We present a modular strategy to create bacterial #biohybrids with magnetic motility, #biosensing and cargo release. 👏🏻huge congrats to Nina on her first first-author paper and thanks to Yuval and Matt for the great collaboration! pubs.rsc.org/en/content/a... @rsc.org

Researchers introduce UltraID-LIPA, an innovative platform that combines the light-inducible protein aggregation (LIPA) system with the UltraID proximity-dependent biotinylation assay to identify #Parkinsons-associated α-synuclein-interacting proteins www.cell.com/iscience/ful...

An #OpenSource #automated liquid handler from a #3Dprinter: - made from an #Ender3 Pro - #printing & #pipetting mode reversible - unfortunately: fixed pipetting volume -> #education - cost ~US $325 doi.org/10.1021/acs.... #DIYbio #lab #3Dprinted #ALH #MINT #STEM #EDU #instruments

New open access article online: Electrochemical fluorescence modulation enables simultaneous multicolour imaging. bit.ly/3GhgOAY

Please repost: PhD position with my lab and @weisslab.bsky.social in a great collaboration on bacterial adhesion #microsky. See drive.google.com/file/d/1GJD4...

🚂🧬 How do tiny cellular trains turn around? Using live C. elegans, Erwin Peterman of Vrije Universiteit Amsterdam shows how kinase DYF-5 controls IFT train reversals. Without it, traffic jams pile up at the ciliary tip. 🔍 Read: www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology

Peroxisomal membrane protein is our #CellLineOfTheWeek - illuminating the peroxisomes! 🧫 Our high-quality stem cell lines and plasmids are available for just the cost of shipping to reduce the barriers to discovery. 📦 Distributed by @coriellinstitute.bsky.social and @addgene.bsky.social.

Finally out in Nature Chem Bio: SNAP-tag2 for faster and brighter protein labeling www.nature.com/articles/s41... Thank you Steffi and Veselin.

Please check out our new high-affinity split-HaloTag for live-cell protein labeling www.biorxiv.org/content/10.1... Congratulations to Yin-Hsi Lin!

making nucleoids visible in live cells, wow... btw jacob, brenner & cuzin (1963) already suggested that the nucleoid attaches to the membrane schaechter.asmblog.org/schaechter/2... #MicroSky

Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...

We are excited to share our development of a new 10X lens with NA=0.50 over a 7.2 mm FOV and a 35 mm working distance (water), fully corrected from 400-850 nm. This lens will power our upcoming ExA-SPIM "2" and is available for dissemination - please get in touch if interested!

Spatial entropy drives the maintenance and dissemination of transferable plasmids doi.org/10.1038/s443...

#ImageScanningMicroscopy inherently encodes aberration info. No extra hardware needed! A #CNN decodes Zernike modes directly from a single acquisition. A new data-driven path to #AdaptiveOptics in #LSM! doi.org/10.1364/BOE.... #PhotonResolvedMicroscopy #SPADarray @iitalk.bsky.social @erc.europa.eu

Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!

Check out the latest preprint on high-throughput force spectroscopy from Assoc. Faculty member Wesley Wong's lab. They've developed a next-gen CFM with multichannel fluorescence capabilities to study the avidity of immune cells at the single cell level. #Preprint #Nanotechnology

Our Lectin-PAINT work is out! A super-resolution approach to study membrane-exposed glycans with nm resolution and in live cells. Multiplexed 8-colors imaging mapping heterogeneity in "glycotype" with single molecule resolution. Fantastic work of our Marrit! #Glycotime www.nature.com/articles/s42...

We present: Direct-view oblique plane microscopy www.biorxiv.org/content/10.1...

Impressive!

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

MagLOV! MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social. We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!). bsky.app/profile/addg...