Chronic inflammation has long been linked to cancer, but how is that history retained in the tissue? In a new #Nature study, Nagaraja et al show that colitis leaves a lasting epigenetic memory in colonic stem cells, which persists after inflammation resolves & primes for subsequent tumor growth 🧪🔬

Kuhn, @maxkrummel.bsky.social et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment rupress.org/jem/article/... #TME #CAFs #TumorImmunology

#Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow #monocytes after #stroke. New study from Weijie Chen, Xin Wang, Tingting Huang, Weifeng Yu, Florent Ginhoux, Peiying Li (Shanghai Jiao Tong University) and colleagues: rupress.org/jem/article/... #Neuroinflammation

@biorxivpreprint.bsky.social systematic mapping of immune landscape alterations during sequential lymph node metastasis in humans provides essential insights for understanding cancer metastasis www.biorxiv.org/content/10.6... @universitypress.cambridge.org

AP-1 mediates cellular adaptation and memory formation @natcomms.nature.com @pennmedicine.bsky.social @arjunraj.bsky.social @penngenetics.bsky.social www.nature.com/articles/s41...

For a recent lab meeting, I wrote up a grab bag of ways to think about your development as a researcher during a PhD: emerge-lab.github.io/papers/an-un... Sharing in case folks find it useful or have feedback!

The reactivation of herpes simplex virus (HSV-1, not only herpes zoster) may be tied to accelerated aging and dementia, and account in part for the mechanism of Shingrix vaccine''s protection www.wired.com/story/shingl...

#Myeloid cells infiltrate tumors from early transformation to advanced disease; however, their plasticity complicates therapeutic targeting. Nogales-Pons et al. @casanova-acebes.bsky.social review emerging technologies that uncover unexpected cellular states & functions rupress.org/jem/article/...

Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance

Lactation supports babies' immune health and reduces the risk of breast cancer for the mother. spkl.io/63327Avl8f Abigail Jaquish & Deepshika Ramanan @cp-trendsimmuno.bsky.social

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding @nature.com @danafarber.bsky.social @harvardmed.bsky.social @judithagudo.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41...

@biorxivpreprint.bsky.social PTPN1/2 inhibits alveolar macrophage-mediated control of lung metastasis www.biorxiv.org/content/10.6...

new out in Nature www.nature.com/articles/s41...

Automated discernment of prognostic spatial features of #TNBC specific to cell interactions at the tumor border or metastatic site @natcancer.nature.com @noahgreenwald.bsky.social @joleneranek.bsky.social www.nature.com/articles/s43... www.nature.com/articles/s43... www.nature.com/articles/s43...

Insights: Frosio and Ostuni @unisr.bsky.social discuss new study by Gorin et al. (rupress.org/jem/article/...) which reveals an unexpected mechanism by which IFN-γ sustains trained immune states through prolonged signaling driven by cytokine retention at the cell surface. rupress.org/jem/article/...

Modeling the evolutionary dynamics of clonal hematopoiesis @natgenet.nature.com @moffittnews.bsky.social www.nature.com/articles/s41...

🚨 NEW 🚨 "Systemic hypoxia suppresses solid tumor growth" @ayushmidha.bsky.social @genophoria.bsky.social @ishahjain.bsky.social @arcinstitute.bsky.social @ucsfhealth.bsky.social https://bit.ly/4arkFX8

Cool to see data backing up an anecdote I have been told - that short (1 hour) formaldehyde fixation can be better than longer (6 hours+) fixation for staining some antigens:

Intracellular bacteria in cancer cells promote immunosuppression in the metastatic niche

Matrix-bound nanovesicles elicit epigenetic changes in myeloid cells, modulating their response to future inflammatory events www.science.org/doi/10.1126/...

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis @cp-cellchembiol.bsky.social @danafarber.bsky.social www.cell.com/cell-chemica...

IFN-γ-induced trained immunity enhances killing of priority pathogens in healthy and genetically vulnerable individuals @insight.jci.org @tcddublin.bsky.social insight.jci.org/articles/vie...

Now online! CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response

Chrysanthi Moschandrea and I have developed a new conceptual framework for understanding the role of metabolism in cancer, which we term metabolic permissiveness. We are eager to hear your thoughts on this topic. genesdev.cshlp.org/content/earl...

Targeting Myc activates a tissue-specific tumour resolution programme https://www.biorxiv.org/content/10.64898/2026.02.06.704498v1

Two doses of Recombinant zoster vaccine reduces dementia risk 51% lower risk of dementia (in females > males) even accounting for healthy vacinee bias versus Tdap @natcomms.nature.com www.nature.com/articles/s41...

S1PR1 signaling biases neutrophils toward long-lived low-inflammatory functional states https://www.biorxiv.org/content/10.64898/2026.02.05.703783v1

Some of the latest work from our lab from outstanding scientist Sensen Lin @ctbatucsf.bsky.social @ucsfcancer.bsky.social We find MYC- driven #livercancer are dependent on methionine metabolism. This includes a dependence on the ribosomal rRNA methyltransferase NOP2 that is a MYC target. 🧪

Red blood cells typically don’t move independently, but 1% of those infected by the protozoan parasite Babesia microti show clear directional movement, possibly allowing the parasite to move through the blood and infect new red blood cells. In PNAS: https://ow.ly/L96h50Y9uTK

Now online! Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment

In a preclinical breast cancer metastasis model, the same bacteria strain, when present intracellularly versus extracellularly, exerts opposing effects on tumor immunity by inducing divergent neutrophil states @cellcellpress.bsky.social www.cell.com/cell/fulltex...

In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...

Metastasis gets a little help from immune cell mitochondria @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol... www.cell.com/cell-metabol...

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer https://www.biorxiv.org/content/10.64898/2026.01.31.701004v1

Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis. https://www.biorxiv.org/content/10.64898/2026.01.28.702329v1

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

Just out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.

Transcriptomic Plasticity is a Hallmark of Metastatic Pancreatic Cancer, by Christine Iacobuzio-Donahue, @danapeer.bsky.social et al. pubmed.ncbi.nlm.nih.gov/41379552/ introduces a new single-cell method named PICASSO: Phylogenetic Inference of CNA in Single-cell RNA [...] github.com/dpeerlab/pic...

I am thrilled to announce that our latest paper is out now in @cp-cancercell.bsky.social! 1/n www.sciencedirect.com/science/arti...

Sharing our latest by Filio Karakousi online today in @cp-cancercell.bsky.social ! authors.elsevier.com/a/1mUU45TA51... We demonstrate that cytotoxic immune responses metabolically program the lymphatic vasculature to restrain regional metastasis and promote immunity!

new out in Nature www.nature.com/articles/s41...

💡 Have you ever wondered how #circulating #tumor cells squeeze through narrow #capillaries during hashtag#metastasis ? 💥 We did, check out our latest publication just out #NatureMaterials: rdcu.be/eZHxJ

When blood mutations turn beneficial

#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!

Obesity rewires nucleotide metabolism in immune cells, making inflammatory responses via NLRP3 inflammasome much easier to trigger www.science.org/doi/10.1126/... @science.org @zhenyuzhong.bsky.social @utswim.bsky.social

🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org

Online now: Mutational landscape of normal breast tissues adjacent to invasive breast cancer

new out in Nature www.nature.com/articles/s41...

Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...