Researchers led by Ludwig @harvard.edu’s @judithagudo.bsky.social Monica Cassandras & Xavier Sanchez have identified in preclinical studies a mechanism metastasizing triple-negative breast cancer cells engage to thwart immune attack & a drug that could disrupt it to curtail metastasis bit.ly/4r7kJBp

www.nature.com/articles/s41... The seeds of metastasis harness stress hormones to escape immune surveillance. So proud of this work! @harvardmed.bsky.social @danafarbernews.bsky.social @dfcibreastonc.bsky.social

New research published by @danafarber.bsky.social’s Judith Agudo, PhD, and colleagues in @nature.com today reveals a new strategy to prevent the metastasis of triple-negative breast cancer. ➡️ bit.ly/4rLuOFj

Why does cancer come back after years of remission? @nature.com shares how researchers are uncovering what causes dormant tumor cells to reawaken. @judithagudo.bsky.social offered insights into why tumor cells may enter dormancy as a protective mechanism. Read more: bit.ly/4btv5Y6

Our researchers are using novel spatial tools to learn how immune cells affect cancer. “I don’t think we appreciated how much the spatial dynamics of the immune system matter,” says @judithagudo.bsky.social. Learn more about what researchers are learning from this technology: bit.ly/49uOtSg

Honored to contribute on this piece explaining why cancer comes back (sometimes years later) with leaders in the field!🤩

Why cancer can come back years later — and how to stop it www.nature.com/articles/d41...

Important to see the acknowledgement of cancer dormancy & that top journals continue to highlight & publish on this topic. This problem is now studied in major Institutions worldwide. Congrats to all who work in this space! It is making & will make a difference! www.nature.com/articles/d41...

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment go.nature.com/3NgcKDT

In commentary published in Cancer Cell, @danafarber.bsky.social’s @judithagudo.bsky.social contends that integrating cancer cell phenotypic heterogeneity into spatial analyses is essential to reveal the mechanisms that generate TIME diversity and address resistance to immunotherapy. bit.ly/496Mc0Y.

Lab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate. @cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation. He is on the job market!

Congrats! Indeed, so beautiful!

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Bone appetite: bone-derived factors feed distant immune suppression

www.sciencedirect.com/science/arti... Stellar postdoc @debolina-ganguly.bsky.social and I wrote this spotlight for a super cool paper on the systemic effects of metatasis. The organ of metastatic diseases makes A BIG difference! Highly recommended paper in @cp-cancercell.bsky.social

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage www.science.org/doi/10.1126/... @science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social

PICI Investigator @judithagudo.bsky.social, PhD, was recognized with the 2025 CRI Lloyd J. Old STAR Award, one of immuno-oncology’s highest honors from the Cancer Research Institute (CRI). Congratulations, Dr. Agudo! www.cancerresearch.org/media-room/2...

Thanks to other support that enabled this recognition @parkerici.bsky.social the NYSCF and the department of defense breast cancer program

Honored and excited to receive the CRI Lloyd Old STAR award. I can barely believe it! Thanks to everyone in my lab and all my collaborators at DFCI, HMS and beyond @cancerresearchinst.bsky.social @dfcibreastonc.bsky.social @danafarber.bsky.social @harvardmed.bsky.social

NIH funding to HMS, including for ImmGen, has been terminated. This threatens tools used by 10,000+ immunologists globally. Please email support for ImmGen’s value to you to Immgen(at)gmail.com, your Senator (US), or US Embassy (abroad). Thanks The ImmGen Team #immgen #supportScience #NIHfunding

Thanks @reinacampos.bsky.social for inviting me to @lji.org and UCSD. This has been a super fun visit! it is so amazing and energizing to meet in person!

I look forward to hosting @judithagudo.bsky.social at LJI, please join us! snacks and **Free parking**

Going through Green Card application now with current climate, just to add to the uncertainty on funding in research. I need some positive thoughts!

We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons. www.science.org/doi/10.1126/...

Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...

So excited to see how quickly #StandUpForScience has grown from a single rally to rallies in 32 cities in 27 states and counting! Let's go! Thank you for your leadership @standupforscience.bsky.social! They also opened up a donation page 🧪 standupforscience2025.org/local-event-...

When efforts on DEIB are at risk, all help is great. Plus, I love the bame of these awards. Sharing for those that may benefit, applying for a job requires preparation💪🏿💪🏾💪🏽💪🏼💪🏻

"… it is the words and actions of all members of the scientific community … that form the collective voice of science …," writes @holdenthorp.bsky.social in a new #ScienceEditorial. scim.ag/4hR6ux0

2 PhD students recently met at a conference & Trump's slashing of research & science bound them With only 3 other scientists they started a movement that's growing around the country On March 7 in Washington DC, and state capitals, "Stand Up for Science" will take place All details below & bravo!

Funny that the $4B they want to save is the same amount SpaceX got last year in gov't contracts. That even paid the SpaceX CEO $4M! Rockets might be cool and all, but if choosing between rockets and life-saving medicine..You know, maybe the rich guy who wants to play with rockets should pay himself.

Speak up!!! Please email & call you Congress Reps today to oppose these cuts to NIH-especially if you are a scientist living in a red state. Here’s where to find them: www.congress.gov/members/find...