Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social

We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs

Wow!!! 👏👏👏 Amazing to see this develop over the years! www.nytimes.com/2025/06/20/h...

☕Have you read this study from our journal (@naturecellbiology.bsky.social) yet? Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology. bit.ly/4lSORPV

Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...

some GD T cell lymphomas are addicted to JAK-STAT signaling and relapse with new JAK-STAT mutations, much like melanomas to BRAF inhibitors. ? new approach ? to treating these aggressive diseases. cell of origin (GD cells) important but unclear why. stay tuned for more. www.jci.org/articles/vie...

DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity www.science.org/doi/10.1126...

Review @jimmunol.bsky.social Can autoimmune disease be cured by deep CD19+ cell depletion? doi.org/10.1093/jimm...

Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering www.nature.com/articles/s41...

Thanks to Dr. Syal & @nbcnews.com for visiting our #CARTcell program to highlight one of our courageous little patients with #DIPG #DMG. So much work left to do but thankful for the support of Seattle Children’s and our brave families. ❤️ www.nbcnews.com/now/video/ex...

AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity www.cell.com/cell-reports... @cp-cellreports.bsky.social

New #ScienceImmunology research involving mice and human tissues demonstrates how different immune cell types modify expression of stimulator of interferon genes (STING) to support their normal development and function. scim.ag/4idx7wn

How does sleep protect against neurodegenerative disease? A review, open-access www.cell.com/neuron/fullt...

Congratulations! Great talk at keystone

Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert bystander suppression in vivo www.science.org/doi/10.1126/...

⁦‪#InterferonPower! Hongbo Chi‬⁩ &co @stjude.bsky.social @stjuderesearch.bsky.social show ⁦‪@nature.com‬⁩ that VDAC2 deficiency facilitates tumor destruction by T cell-driven IFNgamma by causing mitochondrial (mt) damage & mtDNA sensing by cGAS–STING, which drives type I IFNs & tumor death!

Congratulations!

#ScienceSaturday 🧵 ❓ Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.

🎉 Congratulations 🥳 to our Director, @miriammerad.bsky.social, on winning this year’s Sjöberg Prize! Check out the video announcement below 🔽

Review @nature.com @quintanalab.bsky.social The neuroimmune connectome in health and disease www.nature.com/articles/s41...

Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice www.science.org/doi/10.1126/...

PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism www.science.org/doi/10.1126/...

In chaotic times, it is important to emphasize how much i appreciate my fellow scientists and the science they do. Inspired countless times each day by my colleagues in the field.

The best part of science for me is when someone in the lab or a former lab member has awesome new data and rushes to share it. everything else pales in comparison.

Going post new things here and not on X. Will be focused on science/career development and drug development, with the occasional sports (Mets, Knicks, hockey) tweet..

Grants should focus more on the person/people doing the science>>the specific experimental minutae. Flexibility to follow the path the data illuminates>>>milestones and deliverables.

Cool paper using LLM to discover a protein sequence code for subcellular localization 👏 www.science.org/doi/10.1126/...

I believe that most of our society values science and scientists. We need to continue to communicate our findings and value to the public and advocate for increased research funding, especially for young investigators->they are the future.

In Brief: bluebird bio and @vertexpharma.bsky.social are the first to participate in a scheme to enable people with sickle cell disease to access treatments they would otherwise not be able to afford nature.com/articles/s41... rdcu.be/d7Hss

What do (some) hiring committees look for in a scientist? The ability to go into new fields and reinvent yourself. open.spotify.com/episode/6Z2e...

Review @natrevmcb.bsky.social The roles of mitochondria in global and local intracellular calcium signalling www.nature.com/articles/s41...

Fly eagles fly!

Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa @naturecomms.bsky.social www.nature.com/articles/s41...

#Review 🚨 Can targeting mutant protein-protein interactions (PPIs) lead to new cancer therapies?🤔 Check out our latest Review from Fu, Mo and Ivanov to answer this! They explore the mechanisms by which oncogenic mutations impact PPIs, technologies for studying this & the therapeutic implications.

Interesting paper from the Kipnis lab on "regulatory" self-peptides instructing unconventional Tregs to promote tolerance "the CNS presents select endogenous self-peptides on MHC-II molecules to communicate with and dampen autoreactive T cell responses to secure CNS immunosurveillance" #ImmunoSky 🧪

📢 Applications for the NKI PhD program now open till Feb 28. Several exciting positions available, including one in my lab on discovering new biology and therapeutic opportunities of a population of enriched tumor-reactive T cells we recently identified. www.nki.nl/careers-stud...

Excited to announce my next chapter: This spring, I'm joining @UTSWNews as the inaugural Director of the Center for Cellular Therapies and Cancer Immunology! Looking forward to building innovative #immunotherapy programs and advancing #cancerresearch with the outstanding team at UTSW.

Interesting new research from Antoine Marçais’ lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells. #immunology #NKcells #Immunometabolism doi.org/10.1038/s422... See our commentary article here: www.nature.com/articles/s42...

Review @natrevimmunol.bsky.social Cancer immune evasion, immunoediting and intratumor heterogeneity www.nature.com/articles/s41...

Cool!

new out in Nature www.nature.com/articles/s41...

Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon

A.I. hallucinations are reinvigorating the creative side of science. They speed the process by which scientists and inventors dream up new ideas and test them to see if reality concurs. It’s the scientific method only supercharged helping scientists open new frontiers www.nytimes.com/2024/12/23/s...

"Co-first? don't think so"

The 90/10 rule of scientific discovery: 90% of your results come from 10% of your explorations, but it's not possible to know in advance what specific explorations those will be.

Congrats!!

looks cool. looking forward to reading about this.

Congrats!

Check out this fantastic study from @tcellogic.bsky.social & colleagues out now in @science.org !