Rory Mulloy
@rorymulloy.bsky.social
📤 141
📥 301
📝 23
PhDing in the @CorcoranLab, dabbles with RNA granules, viruses, and the outdoors
pinned post!
💥 Paper published 💥 Curious how
#SARS2
has changed since jumping into humans? We were too!
journals.plos.org/plosbiology/...
🧵 🧵 🧵
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Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003646
4 months ago
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Noga’s brain child hits (pre)print! A very neat story at the confluence of viruses, RNP granules, and warnings about assuming beta coronaviruses all play by the same rules…
add a skeleton here at some point
1 day ago
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Less private jets, more water bombers
1 day ago
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A lovely paper out of the Locker lab from Dr. Marques! Picornaviruses really hate G3BP1. Methodical breakdown of the antiviral role of RNA granules vs granule proteins, not an easy thing to do. Worth reading for the stunning microscopy alone! Congrats
add a skeleton here at some point
5 days ago
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Rory Mulloy
Mariana Marques
5 days ago
It's out! 🎉 Excited to share our latest paper in
@plos.org
Pathogens! We set out to understand the role of
#StressGranules
in the
#antiviral
response against
#RNAviruses
, using
#FMDV
as our model. Here's what we found:
dx.plos.org/10.1371/jour...
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The assembly of stress granules during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling
Author summary Biomolecular condensates, including stress granules, are key regulatory compartments that control fundamental cellular processes. By condensing RNAs and proteins, these structures enabl...
https://dx.plos.org/10.1371/journal.ppat.1013722
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Rory Mulloy
Thelonevirologist
6 days ago
Super-resolution atlas of SARS-CoV-2 infection reveals protease-dependent organelle maturation, dsRNA landscapes, and intracellular structural proteins
www.nature.com/articles/s41...
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Super-resolution atlas of SARS-CoV-2 infection reveals protease-dependent organelle maturation, dsRNA landscapes, and intracellular structural proteins - Nature Communications
Multi-color super-resolution microscopy provides an atlas of SARS-CoV-2 viral RNA and proteins in infected human cells, uncovering nanoscale aspects of protease-dependent replication organelle maturat...
https://www.nature.com/articles/s41467-026-75289-x
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Rory Mulloy
Journal of Cell Science
26 days ago
We are pleased to be a media partner for the
@embo.org
@embl.org
Symposium: The complex life of RNA Abstract submission: 7 Jul 2026 Registration (On-site): 1 Sep 2026 Registration (Virtual): 6 Oct 2026
bit.ly/4qpp83e
#EESRNA
@events.embl.org
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Rory Mulloy
Harmit Singh Malik
about 1 month ago
add a skeleton here at some point
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Rory Mulloy
Ed Hagen
about 2 months ago
🧪
add a skeleton here at some point
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BK. Titanji
about 2 months ago
Today the first recovered patient was released from an Ebola treatment unit in the DRC after two negative tests. Because so much of the Ebola news is so dark and filled with despair I want to make sure I am intentional about sharing the wins.
www.thenationalnews.com/news/mena/20...
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First patient recovers from Ebola but WHO warns of 'huge' death rate | The National
Nine cases confirmed in Uganda after virus spread in central Africa
https://www.thenationalnews.com/news/mena/2026/05/29/first-patient-recovers-from-ebola-but-who-warns-of-huge-death-rate/?utm_term=Autofeed&utm_medium=Social&utm_source=Threads#Echobox=1780073826
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Cedric Feschotte
about 2 months ago
Wrote a short piece on Transposable Elements as catalysts of evolutionary innovation for a forthcoming special issue of
@naturerevgenet.bsky.social
on, duh, Evolutionary Innovation!
www.nature.com/articles/s41...
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Transposable elements as catalysts of evolutionary innovation - Nature Reviews Genetics
In this Comment, Cedric Feschotte highlights evidence from diverse lineages showing that transposable elements are key drivers of evolutionary innovation, repeatedly introducing regulatory and coding ...
https://www.nature.com/articles/s41576-026-00980-0
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Rory Mulloy
Kathrin Leppek
about 2 months ago
🚨 1/5 Check out the 2nd preprint from our lab on how IRES-mediated translation of synthetic circRNAs is employed in cells and in cell-free translation extracts, a highly collaborative effort with
@immagina.bsky.social
& the labs of
@andershlund.bsky.social
and CK Chen
www.biorxiv.org/content/10.6...
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Really neat paper suggesting that STING helps nucleate stress granules near the ER. This beautifully and physically highlights the integration of classical antiviral pathways and RNP granules
www.nature.com/articles/s41...
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STING is the scaffold protein for stress granule pre-condensation at the ER - Cell Death & Differentiation
Cell Death & Differentiation - STING is the scaffold protein for stress granule pre-condensation at the ER
https://www.nature.com/articles/s41418-026-01734-5
about 2 months ago
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Rory Mulloy
Waggoner Lab
about 2 months ago
An engineered viral RNA degrader on mitochondrial surface that mitigates RNA virus infection
@natcomms.nature.com
www.nature.com/articles/s41...
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Rory Mulloy
Laura Lorenzo Orts
2 months ago
We should all think twice before providing personal feedback on scientific presentations. For example, criticizing an accent is pointless. If you had difficulty understanding a presentation, suggest that the speaker slow down; don't point out their origin.
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Rory Mulloy
2 months ago
So how do mRNAs get localised at specific areas of the cell if there are no unifying sequence or structural patterns? Work from the labs of
@simonbullock11.bsky.social
@carter-lab.bsky.social
@natsmb.nature.com
provides insightful answers to this longstanding question.
www.nature.com/articles/s41...
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Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
https://www.nature.com/articles/s41594-026-01794-8
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Rory Mulloy
The EMBO Journal
3 months ago
Retrovirus insertions in host transcripts trigger de novo piRNA immunity: Kirsten-André Senti,
@juliusbrennecke.bsky.social
et al investigate the 20th-century invasion of D. melanogaster by iERV Tirant to reveal piRNA-pathway evolution in response to new threats
link.springer.com/article/10.1...
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Retrovirus insertions in host transcripts trigger de novo piRNA immunity - The EMBO Journal
How host organisms adapt their defense systems to newly invading transposable elements remains poorly understood. Here, we show how Drosophila melanogaster acquired PIWI-interacting RNA (piRNA)-mediat...
https://link.springer.com/article/10.1038/s44318-026-00777-1
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SUPER COOL to have my recent paper highlighted by CoV transcription legends, Drs Isabel Sola & Sonia Zuñiga in a PLoS Bio Primer. A much better read than the AI summary of the paper 💥
journals.plos.org/plosbiology/...
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New transcription signals in SARS-CoV-2 reshape virus–host interactions
Non-spike changes driving SARS-CoV-2 fitness remain undiscovered. This Primer comments on two PLOS Biology papers that show that evolutionary N gene mutations create a transcription-regulating sequenc...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003744
3 months ago
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Very cool to finally be able to see what is going in with SARS-CoV-2/sarbecoviruses in horseshoe bats!
add a skeleton here at some point
3 months ago
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Rory Mulloy
Hank Green
3 months ago
I did some research to try and figure out when my death date would be if there had been no treatment for my cancer. I don't know why I assumed it would be some date in the future, but, in fact, I passed the middle of the "no treatment survival" bell curve more than a year ago. Thanks chemo.
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Alfredo Castello
4 months ago
Proud of Louisa Iselin. Not the easiest PhD, covid, two supervisors (
shabazlab.bsky.social
) moving labs, but she pushed through and delivered a really solid piece of work on how interferon reshapes RNA-protein interactions post-translationally
www.cell.com/cell-reports...
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RNA binding as an emerging regulatory dimension in the type I IFN response
Iselin et al. explore how the type I IFN response regulates RNA-binding activity using RNA-interactome capture and extend the RIC protocol to assess the role of phosphorylation in this process. Focusi...
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00252-4
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💥 Paper published 💥 Curious how
#SARS2
has changed since jumping into humans? We were too!
journals.plos.org/plosbiology/...
🧵 🧵 🧵
loading . . .
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003646
4 months ago
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11
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reposted by
Rory Mulloy
PLOS Biology
5 months ago
Despite decades of intensive research, current approaches to treating
#NeurodegenerativeDiseases
only slow down the seemingly inevitable. Could recent data associating
#vaccines
with reduced risk of
#dementia
offer an unexpected beacon of hope?🧪
@sparrerlab.bsky.social
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Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lower…
https://plos.io/4aw4TtR
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Rory Mulloy
Ed Hutchinson
5 months ago
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
www.science.org/doi/10.1126/...
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Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to women’s fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibite...
https://www.science.org/doi/10.1126/science.adv5257
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Rory Mulloy
Lex McMenamin (they/them)
6 months ago
RIP Catherine O'Hara, I have never not laughed at this
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Schitt's Creek - Moira laughs without moving her mouth
YouTube video by Raremedia
https://www.youtube.com/watch?v=mDHuxXsULcM
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Rory Mulloy
Harmit Singh Malik
6 months ago
This one might be even better
@barrlab.bsky.social
add a skeleton here at some point
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Although using AI for science writing is spooky, I feel like now I’m allowed to write with more pizzazz (just to show im human)
6 months ago
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Rory Mulloy
Science News
6 months ago
Writing is thinking "On the value of human-generated scientific writing in the age of large-language models."
www.nature.com/articles/s44...
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Rory Mulloy
Nature Communications
6 months ago
#Virology
Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
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ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications
Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.
http://dlvr.it/TQNpCz
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Rory Mulloy
Waggoner Lab
6 months ago
Review
@natrevimmunol.nature.com
@martint-babraham.bsky.social
@babrahaminst.bsky.social
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
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Rory Mulloy
Stern-Ginossar Lab
6 months ago
Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper :
rdcu.be/eY5gx
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N1-Methylpseudouridine directly modulates translation dynamics
Nature - N1-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.
https://rdcu.be/eY5gx
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Rory Mulloy
A Kelvin
7 months ago
Very happy to share my latest preprint on clade IIb MPXV. After infection in a mouse model, the virus had highest titre in the testes with delayed clearance. This led to significant destruction in the testes and reduced sperm - what are the longterm implications?
www.biorxiv.org/content/10.6...
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MPXV Clade IIb virus infection in mice leads to prolonged viral replication, macrophage infiltration, and decreased spermatogenesis in the testes
Mpox (formerly monkeypox) is caused by monkeypox virus (MPXV) and has prompted two recent global health emergencies. Clade IIb MPXV, a recently recognized subclade, has been associated with oral and g...
https://www.biorxiv.org/content/10.64898/2025.12.16.694558v1
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Christmas present to me! I won first place in the LCI/CMF Striking Image Competition! Thanks to the LCI and CMF teams!
7 months ago
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Rory Mulloy
Thelonevirologist
7 months ago
Two ancient humans, including famed ‘Iceman,’ had cancer-causing virus
www.science.org/content/arti...
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Two ancient humans, including famed ‘Iceman,’ had cancer-causing virus
Findings from ancient DNA may shed light on HPV’s history in our species
https://www.science.org/content/article/two-ancient-humans-including-famed-iceman-had-cancer-causing-virus
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Rory Mulloy
Waggoner Lab
7 months ago
Recombination between strains fuels pervasive adaptive evolution among human gut commensal bacteria, and strongly implicate host diet and lifestyle as critical selection pressures
@nature.com
@nanditagarud.bsky.social
www.nature.com/articles/s41...
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Rory Mulloy
Matthew Taliaferro
7 months ago
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
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Rory Mulloy
Federico Teloni
8 months ago
I am happy to share that my postdoctoral work in the
@gerlichlab.bsky.social
at
@imbavienna.bsky.social
is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉
www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
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Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
https://www.science.org/doi/10.1126/science.adw0566
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Rory Mulloy
Waggoner Lab
8 months ago
mRNA circularization is crucial for initiating codon-usage-dependent translation, whereas viral RNAs bypass this mechanism by blocking circularization, allowing efficient translation despite poor codon usage
@nature.com
#LiuLab
www.nature.com/articles/s41...
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Rory Mulloy
Jan Rosenow
8 months ago
Energy transitions can happen faster than we think: In 2000 almost 90% of Denmark's electricity was from fossil fuels. In 2024 less than 10% of Danish electricity was from fossil fuels.
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Rory Mulloy
Bosse lab at CSSB Hamburg
8 months ago
Do you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT!
doi.org/10.1002/anie...
Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648
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Live‐Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters
The intracellular delivery of trans-cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron-demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro)....
http://doi.org/10.1002/anie.202516613
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Rory Mulloy
Broz Lab
8 months ago
November is a big month for the lab with *two* new papers by
@ehartenian.bsky.social
and
@alexandraboegli.bsky.social
++ co authors now online.
www.embopress.org/doi/full/10....
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NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
https://www.embopress.org/doi/full/10.1038/s44319-025-00638-8
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Rory Mulloy
Brent Toderian
8 months ago
“Someone with a 1-hr car commute needs to earn 40% more to be as happy as someone with a short walk to work. On the other hand, if someone shifts from a long commute to a walk, their happiness increases as much as if they’d fallen in love.”
#CityMakingMath
50 reasons to want more walkable cities.
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50 Reasons Why Everyone Should Want More Walkable Streets
From making you live longer to making cities more resilient: If you want a reason to make your city more walkable, it's in here.
https://www.fastcompany.com/3062989/50-reasons-why-everyone-should-want-more-walkable-streets
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Rory Mulloy
Thelonevirologist
8 months ago
Persistent mirusvirus infection in the marine protist Aurantiochytrium
www.nature.com/articles/s41...
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Persistent mirusvirus infection in the marine protist Aurantiochytrium - Nature Communications
Mirusviruses were detected in metagenomic datasets, but little is known about how they infect their hosts. Here, the authors characterize mirusviruses in the marine protist Aurantiochytrium, detecting...
https://www.nature.com/articles/s41467-025-65172-6
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Rory Mulloy
Thelonevirologist
8 months ago
Multiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific activity
journals.asm.org/doi/10.1128/...
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Multiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific activity | Journal of Virology
Mechanisms of membrane fusion and determinants of host range for pathogens remain poorly understood. Improved understanding of these concepts could open new areas for therapeutic development and shed light on virus epidemiology. Our analyses of NSP1-1 proteins from species B, G, and I rotaviruses provide insights into the variability tolerated by functional FAST proteins. Further, the observation that all putative FAST proteins tested can induce syncytium formation in at least some cell types provides evidence that rotaviruses that encode NSP1-1 proteins are fusogenic viruses. Finally, although the criteria for their specificity remain unclear, our observations regarding fusion capacities of different NSP1-1 proteins and of chimeric FAST proteins suggest a potential role for rotavirus FAST proteins in determining the efficiency of viral replication within a given host or cell type.
https://journals.asm.org/doi/10.1128/jvi.01587-25
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Rory Mulloy
David Bartel's Lab
9 months ago
Check out the latest work from our lab, led by Arash Latifkar
@ara-latifkar.bsky.social
,
www.biorxiv.org/content/10.1...
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mRNA poly(A)-tail length is a battleground for coronavirus–host competition
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...
https://www.biorxiv.org/content/10.1101/2025.10.09.680815v1
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Rory Mulloy
Max Renner
9 months ago
Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇
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Rory Mulloy
Bruno Di Stefano
9 months ago
1/ Excited to share our new study with
@brumbaugh-lab.bsky.social
, out in
@natbiotech.nature.com
! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵
www.nature.com/articles/s41...
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Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
https://www.nature.com/articles/s41587-025-02853-z
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Rory Mulloy
Harmit Singh Malik
9 months ago
Congrats to the Blue Jays. I’m going to sulk for a few days but what an amazing season for the
@mariners.com
Proud of this team
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Rory Mulloy
Waggoner Lab
9 months ago
Virus driven Disruption of Transcription Termination (DoTT) generated cellular Z-RNAs are bona fide ZBP1 ligands driving cell death as a host response to counter viral disruption of the cellular transcriptional machinery
@nature.com
@foxchasecancer.bsky.social
www.nature.com/articles/s41...
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Rory Mulloy
Mandy Muller
10 months ago
🧬 Exciting news from our lab 🧬 The Swiss National Science Foundation (SNSF) has approved our project studying KSHV and RNA decay: our first grant since re-launching the lab in Switzerland 🎉 We’re now looking for a Postdoc and a PhD student to join the team (start date January 2026) - please repost!
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Rory Mulloy
Joseph Luna
10 months ago
I made a sign for the lab with our informal lab motto, inspired by this convo between
@itaiyanai.bsky.social
and Martin Lercher:
nightscience.buzzsprout.com/1744020/epis...
. A good reminder that talking is among the best forms of thinking!
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