Rory Mulloy
@rorymulloy.bsky.social
š¤ 121
š„ 268
š 9
PhDing in the @CorcoranLab, dabbles with RNA granules, viruses, and the outdoors
pinned post!
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the
@corcoranlab.bsky.social
with
@nogasharlin.bsky.social
, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran
www.biorxiv.org/content/10.1...
12 months ago
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Rory Mulloy
PLOS Biology
2 days ago
Despite decades of intensive research, current approaches to treating
#NeurodegenerativeDiseases
only slow down the seemingly inevitable. Could recent data associating
#vaccines
with reduced risk of
#dementia
offer an unexpected beacon of hope?š§Ŗ
@sparrerlab.bsky.social
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Could targeting viruses be a new hope against neurodegenerative diseases?
Current therapies for neurodegenerative diseases largely manage symptoms and only modestly slow progression. This Perspective highlights emerging evidence that vaccines and antivirals may lowerā¦
https://plos.io/4aw4TtR
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Rory Mulloy
Ed Hutchinson
14 days ago
Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
www.science.org/doi/10.1126/...
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Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development
Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to womenās fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibite...
https://www.science.org/doi/10.1126/science.adv5257
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Rory Mulloy
Lex McMenamin (they/them)
19 days ago
RIP Catherine O'Hara, I have never not laughed at this
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Schitt's Creek - Moira laughs without moving her mouth
YouTube video by Raremedia
https://www.youtube.com/watch?v=mDHuxXsULcM
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Rory Mulloy
Harmit Singh Malik
23 days ago
This one might be even better
@barrlab.bsky.social
add a skeleton here at some point
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Although using AI for science writing is spooky, I feel like now Iām allowed to write with more pizzazz (just to show im human)
about 1 month ago
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Rory Mulloy
Science News
about 1 month ago
Writing is thinking "On the value of human-generated scientific writing in the age of large-language models."
www.nature.com/articles/s44...
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Rory Mulloy
Nature Communications
about 1 month ago
#Virology
Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
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ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications
Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.
http://dlvr.it/TQNpCz
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Rory Mulloy
Waggoner Lab
about 1 month ago
Review
@natrevimmunol.nature.com
@martint-babraham.bsky.social
@babrahaminst.bsky.social
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
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Rory Mulloy
Stern-Ginossar Lab
about 1 month ago
Our new paper is out in Nature š. We show that m1ĪØ in mRNA vaccines doesnāt just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 𧬠Full paper :
rdcu.be/eY5gx
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N1-Methylpseudouridine directly modulates translation dynamics
Nature - N1-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.
https://rdcu.be/eY5gx
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Rory Mulloy
A Kelvin
about 2 months ago
Very happy to share my latest preprint on clade IIb MPXV. After infection in a mouse model, the virus had highest titre in the testes with delayed clearance. This led to significant destruction in the testes and reduced sperm - what are the longterm implications?
www.biorxiv.org/content/10.6...
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MPXV Clade IIb virus infection in mice leads to prolonged viral replication, macrophage infiltration, and decreased spermatogenesis in the testes
Mpox (formerly monkeypox) is caused by monkeypox virus (MPXV) and has prompted two recent global health emergencies. Clade IIb MPXV, a recently recognized subclade, has been associated with oral and g...
https://www.biorxiv.org/content/10.64898/2025.12.16.694558v1
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Christmas present to me! I won first place in the LCI/CMF Striking Image Competition! Thanks to the LCI and CMF teams!
about 2 months ago
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Rory Mulloy
Thelonevirologist
about 2 months ago
Two ancient humans, including famed āIceman,ā had cancer-causing virus
www.science.org/content/arti...
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Two ancient humans, including famed āIceman,ā had cancer-causing virus
Findings from ancient DNA may shed light on HPVās history in our species
https://www.science.org/content/article/two-ancient-humans-including-famed-iceman-had-cancer-causing-virus
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Rory Mulloy
Waggoner Lab
2 months ago
Recombination between strains fuels pervasive adaptive evolution among human gut commensal bacteria, and strongly implicate host diet and lifestyle as critical selection pressures
@nature.com
@nanditagarud.bsky.social
www.nature.com/articles/s41...
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Rory Mulloy
Matthew Taliaferro
2 months ago
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
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Rory Mulloy
Federico Teloni
3 months ago
I am happy to share that my postdoctoral work in the
@gerlichlab.bsky.social
at
@imbavienna.bsky.social
is finally out š! Our study reveals how cohesin guides focused and accurate homology search. Read more š
www.science.org/doi/10.1126/...
Follow along for key insights and updates! š§µ
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Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
https://www.science.org/doi/10.1126/science.adw0566
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Rory Mulloy
Waggoner Lab
3 months ago
mRNA circularization is crucial for initiating codon-usage-dependent translation, whereas viral RNAs bypass this mechanism by blocking circularization, allowing efficient translation despite poor codon usage
@nature.com
#LiuLab
www.nature.com/articles/s41...
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Rory Mulloy
Jan Rosenow
3 months ago
Energy transitions can happen faster than we think: In 2000 almost 90% of Denmark's electricity was from fossil fuels. In 2024 less than 10% of Danish electricity was from fossil fuels.
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Rory Mulloy
Bosse lab at CSSB Hamburg
3 months ago
Do you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT!
doi.org/10.1002/anie...
Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648
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LiveāCell RNA Imaging via Clickable TriPPPro Nucleotide Reporters
The intracellular delivery of trans-cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron-demand DielsāAlder was achieved by the triphosphate prodrug (TriPPPro)....
http://doi.org/10.1002/anie.202516613
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Rory Mulloy
Broz Lab
3 months ago
November is a big month for the lab with *two* new papers by
@ehartenian.bsky.social
and
@alexandraboegli.bsky.social
++ co authors now online.
www.embopress.org/doi/full/10....
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NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
https://www.embopress.org/doi/full/10.1038/s44319-025-00638-8
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Rory Mulloy
Brent Toderian
3 months ago
āSomeone with a 1-hr car commute needs to earn 40% more to be as happy as someone with a short walk to work. On the other hand, if someone shifts from a long commute to a walk, their happiness increases as much as if theyād fallen in love.ā
#CityMakingMath
50 reasons to want more walkable cities.
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50 Reasons Why Everyone Should Want More Walkable Streets
From making you live longer to making cities more resilient: If you want a reason to make your city more walkable, it's in here.
https://www.fastcompany.com/3062989/50-reasons-why-everyone-should-want-more-walkable-streets
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Rory Mulloy
Thelonevirologist
3 months ago
Persistent mirusvirus infection in the marine protist Aurantiochytrium
www.nature.com/articles/s41...
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Persistent mirusvirus infection in the marine protist Aurantiochytrium - Nature Communications
Mirusviruses were detected in metagenomic datasets, but little is known about how they infect their hosts. Here, the authors characterize mirusviruses in the marine protist Aurantiochytrium, detecting...
https://www.nature.com/articles/s41467-025-65172-6
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Rory Mulloy
Thelonevirologist
3 months ago
Multiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific activity
journals.asm.org/doi/10.1128/...
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Multiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific activity | Journal of Virology
Mechanisms of membrane fusion and determinants of host range for pathogens remain poorly understood. Improved understanding of these concepts could open new areas for therapeutic development and shed light on virus epidemiology. Our analyses of NSP1-1 proteins from species B, G, and I rotaviruses provide insights into the variability tolerated by functional FAST proteins. Further, the observation that all putative FAST proteins tested can induce syncytium formation in at least some cell types provides evidence that rotaviruses that encode NSP1-1 proteins are fusogenic viruses. Finally, although the criteria for their specificity remain unclear, our observations regarding fusion capacities of different NSP1-1 proteins and of chimeric FAST proteins suggest a potential role for rotavirus FAST proteins in determining the efficiency of viral replication within a given host or cell type.
https://journals.asm.org/doi/10.1128/jvi.01587-25
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Rory Mulloy
David Bartel's Lab
4 months ago
Check out the latest work from our lab, led by Arash Latifkar
@ara-latifkar.bsky.social
,
www.biorxiv.org/content/10.1...
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mRNA poly(A)-tail length is a battleground for coronavirusāhost competition
Most eukaryotic mRNAs contain a poly(A) tail, which in post-embryonic cells enhances their stability. Many cytoplasmic RNA viruses also harbor poly(A) tails on their genomic RNA and mRNAs. Here, we re...
https://www.biorxiv.org/content/10.1101/2025.10.09.680815v1
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Rory Mulloy
Max Renner
4 months ago
Our new preprint is out š„³š„³š„³ Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? š
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Rory Mulloy
Bruno Di Stefano
4 months ago
1/ Excited to share our new study with
@brumbaugh-lab.bsky.social
, out in
@natbiotech.nature.com
! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. š§µ
www.nature.com/articles/s41...
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Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
https://www.nature.com/articles/s41587-025-02853-z
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Rory Mulloy
Harmit Singh Malik
4 months ago
Congrats to the Blue Jays. Iām going to sulk for a few days but what an amazing season for the
@mariners.com
Proud of this team
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Rory Mulloy
Waggoner Lab
4 months ago
Virus driven Disruption of Transcription Termination (DoTT) generated cellular Z-RNAs are bona fide ZBP1 ligands driving cell death as a host response to counter viral disruption of the cellular transcriptional machinery
@nature.com
@foxchasecancer.bsky.social
www.nature.com/articles/s41...
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Rory Mulloy
Mandy Muller
5 months ago
𧬠Exciting news from our lab 𧬠The Swiss National Science Foundation (SNSF) has approved our project studying KSHV and RNA decay: our first grant since re-launching the lab in Switzerland š Weāre now looking for a Postdoc and a PhD student to join the team (start date January 2026) - please repost!
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Rory Mulloy
Joseph Luna
5 months ago
I made a sign for the lab with our informal lab motto, inspired by this convo between
@itaiyanai.bsky.social
and Martin Lercher:
nightscience.buzzsprout.com/1744020/epis...
. A good reminder that talking is among the best forms of thinking!
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Rory Mulloy
Bloom lab
6 months ago
In new study led by
@bdadonaite.bsky.social
, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2. Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion.
www.biorxiv.org/content/10.1...
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Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants
SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here we use pseudovirus-based deep mutational sca...
https://www.biorxiv.org/content/10.1101/2025.08.18.671001v1
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Rory Mulloy
Trushar Patel, PhD, DSc, FRSC
6 months ago
Collaborative study with Kharpeskyy lab
@dalhousieu.bsky.social
+ our lab
@ulethbridge.ca
(under review) shows: sequence featuresānot secondary structureāof 5ā² UTRs give viral & cellular mRNAs resistance to SARS-CoV-2 Nsp1 host shutoff.
www.biorxiv.org/content/10.1...
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Escape from SARS-CoV-2 Nsp1-mediated host shutoff by TIAR transcript reveals general features of Nsp1 resistance
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune escape strategies include general inhibition of host gene expression referred to as host shutoff. Viral non-structural protein 1 (Ns...
https://www.biorxiv.org/content/10.1101/2025.08.04.668557v1
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Rory Mulloy
Jasmine šš
6 months ago
i love you hubble
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Rory Mulloy
LAFAYETTE
7 months ago
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reposted by
Rory Mulloy
Alex de Mendoza
7 months ago
Giant virus endogenization in Acanthamoeba we covered more in detail in a separate manuscript published some weeks ago in
@bmc.springernature.com
Biology, in a great collaboration with John Archibald's group at Dalhousie:
bmcbiol.biomedcentral.com/articles/10....
. 6/7
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Epigenetic silencing and genome dynamics determine the fate of giant virus endogenizations in Acanthamoeba - BMC Biology
Background Endogenized giant viruses are emerging as major contributors to the genome evolution of microbial eukaryotes, with both degraded and fully functional latent viruses being found integrated i...
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-025-02280-1
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Rory Mulloy
David Grimm
7 months ago
Crab-like creatures are famed for having evolved five times in evolutionary history. But anteaters have evolved at least 12 times--in half the evolutionary span. Cool story by
@jakebuehler.bsky.social
for
@science.org
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āThings keep evolving into anteaters.ā Odd animals arose at least 12 separate times
Findings speak to the dramatic impact ants and termites can have on mammalian evolution
https://www.science.org/content/article/things-keep-evolving-anteaters-odd-animals-arose-least-12-separate-times
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Rory Mulloy
Che Colpitts
7 months ago
Huge congratulations to Dr. Emma LeBlanc on her successful PhD thesis defence yesterday! As my first PhD student, Emma was instrumental in getting my lab up and running, in the midst of a pandemic, while managing to be very productive and do some exciting science along the way!
#proudPI
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Rory Mulloy
Jay Brito Querido
7 months ago
Finally out! Iām thrilled to share our new paper (Wolin et al., Cell 2025). This paper describes SPIDR, a high-throughput method for mapping RBP binding sites. By combining
#SPIDR
with
#cryoEM
, we identified the exact binding site of LARP1 within the
#mRNA
channel of the 40S ribosomal subunit.
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Rory Mulloy
Harmit Singh Malik
8 months ago
Itās too late to save these lost young lives in Texas, but not too late to avert the next tragedy that could be fully avoided. Itās one thing to say youāre making things more efficient and quite another to gut something essential with no replacement. Turn the fāing lights back on! /fin
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Rory Mulloy
Thiago Carvalho
8 months ago
'The myth of meritocracy in science collapses under the financial sacrifices expected at every career stage. From unpaid internships and self-funded conferences to underpaid graduate and postdoctoral positions, the hidden costs of ādoing scienceā are profound.'
journals.plos.org/plosbiology/...
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Too poor to science: How wealth determines who succeeds in STEM
From student to researcher, a career in science can come with a high price tag. This Perspective explores how persistent financial barriers limit who can succeed in science, revealing how wealth shape...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003243
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Rory Mulloy
Jeremy Kamil
8 months ago
š„ Couldnāt be more stoked our study identifying a completely new CMV virion surface complex involved in cell entry is now published at Nature Micro š¦ H/T
@paramyxologist.bsky.social
+ Lauren Henderson, Erica Ollmann Saphire Chris Benedict
@natmicrobiol.nature.com
www.nature.com/articles/s41...
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The GATE glycoprotein complex enhances human cytomegalovirus entry in endothelial cells - Nature Microbiology
The gH-associated tropism and entry (GATE) complex consists of glycoprotein H, UL116 and UL141. This complex is abundant on human cytomegalovirus virions and enables entry into human endothelial cells...
https://www.nature.com/articles/s41564-025-02025-4
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Rory Mulloy
Sarafan ChEM-H
8 months ago
New CRISPR technology developed by
@stanleyqilab.bsky.social
ā¬, Mengting Han & team could pave the way for potential treatments for neurodegenerative diseases like ALS and spinal muscular dystrophy:
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New CRISPR technology could help repair damaged neurons
Stanford researchers have developed a technology that delivers RNA to damaged neurons and stimulates regrowth ā paving the way for potential treatments targeting neurodegenerative diseases like ALSā¦
https://news.stanford.edu/stories/2025/05/crispr-technology-neurodegenerative-diseases-als-spinal-muscular-atrophy
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Rory Mulloy
Nature
8 months ago
Nature research paper: Probing condensate microenvironments with a micropeptide killswitch
https://go.nature.com/4mMlGyc
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Probing condensate microenvironments with a micropeptide killswitch - Nature
Targeting a non-natural micropeptide ākillswitchā to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells
https://go.nature.com/43xbySo
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Rory Mulloy
Alfredo Castello
9 months ago
šØšØ News from the
@castello-lab.bsky.social
and
@shabazlab.bsky.social
. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon.
#RNA
,
#immunity
,
#interferon
,
#host-virus
www.biorxiv.org/content/10.1...
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Rory Mulloy
Ryan Hisner
9 months ago
2nd is the brilliant preprint of
@corcoranlab.bsky.social
&
@rorymulloy.bsky.social
. Itās a deep dive into all things N*, & every other paragraph drops some new, delightful discovery.
www.biorxiv.org/content/10.1...
15/34
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Rory Mulloy
Ryan Hisner
9 months ago
ā¦prompted me to take a closer look, and for reasons Iāll describe below, I now believe rumors of N*ās death are exaggerated. First, XEC is in terminal decline, replaced by variants with full N* expression, so N* is back in fashion. 3/34
journals.plos.org/plosbiology/...
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Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion
Coronaviruses can evolve novel transcription regulatory sequences, generating new RNA transcripts during human infection. This study identifies a prevalent subgenomic RNA in SARS-CoV-2, which produces...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002982
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Rory Mulloy
Ryan Hisner
9 months ago
SGs can form as a response to dsRNA detection, but when Mulloy induced SG formation via a dsRNA-independent pathway, N* still stopped SGs. Mutation of two essential AA for dsRNA binding (K257, K261) showed that N*ās dsRNA binding was required for SG antagonism. 23/34
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Rory Mulloy
Ryan Hisner
9 months ago
An awesome preprint on the novel, unsung SARS-CoV-2 N* protein came out recently, authored by
@corcoranlab.bsky.social
and
@rorymulloy.bsky.social
. Iāve previously written on N*ās demise in XEC, the top variant for several months, butā¦
threadreaderapp.com/thread/18373...
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Rory Mulloy
Carolyn Bertozzi
9 months ago
If people of means are interested in establishing a 2025 āInstitute for Advanced Studyā for displaced/defunded biomedical scientists, I know many people who will help, including myself.
@mcuban.bsky.social
@arcadiascience.com
@arcinstitute.org
add a skeleton here at some point
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Rory Mulloy
Zha Lab
9 months ago
Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come
www.nature.com/articles/s41...
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Ku limits RNA-induced innate immunity to allow Alu-expansion in primates - Nature
Nature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates
https://www.nature.com/articles/s41586-025-09104-w
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Rory Mulloy
Proceedings of the National Academy of Sciences
9 months ago
The parasitic larvae of a wasp inject a virus into their caterpillar hosts that makes the caterpillars aggressive and even cannibalistic when food is scarce, increasing the odds that the parasites and their hosts will survive. In PNAS:
www.pnas.org/doi/10.1073/...
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