Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social

Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development www.science.org/doi/10.1126/...

RIP Catherine O'Hara, I have never not laughed at this

This one might be even better @barrlab.bsky.social

Although using AI for science writing is spooky, I feel like now I’m allowed to write with more pizzazz (just to show im human)

Writing is thinking "On the value of human-generated scientific writing in the age of large-language models." www.nature.com/articles/s44...

#Virology Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process

Review @natrevimmunol.nature.com @martint-babraham.bsky.social @babrahaminst.bsky.social RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41...

Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper : rdcu.be/eY5gx

Very happy to share my latest preprint on clade IIb MPXV. After infection in a mouse model, the virus had highest titre in the testes with delayed clearance. This led to significant destruction in the testes and reduced sperm - what are the longterm implications? www.biorxiv.org/content/10.6...

Christmas present to me! I won first place in the LCI/CMF Striking Image Competition! Thanks to the LCI and CMF teams!

Two ancient humans, including famed ‘Iceman,’ had cancer-causing virus www.science.org/content/arti...

Recombination between strains fuels pervasive adaptive evolution among human gut commensal bacteria, and strongly implicate host diet and lifestyle as critical selection pressures @nature.com @nanditagarud.bsky.social www.nature.com/articles/s41...

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵

mRNA circularization is crucial for initiating codon-usage-dependent translation, whereas viral RNAs bypass this mechanism by blocking circularization, allowing efficient translation despite poor codon usage @nature.com #LiuLab www.nature.com/articles/s41...

Energy transitions can happen faster than we think: In 2000 almost 90% of Denmark's electricity was from fossil fuels. In 2024 less than 10% of Danish electricity was from fossil fuels.

Do you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT! doi.org/10.1002/anie... Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....

“Someone with a 1-hr car commute needs to earn 40% more to be as happy as someone with a short walk to work. On the other hand, if someone shifts from a long commute to a walk, their happiness increases as much as if they’d fallen in love.” #CityMakingMath 50 reasons to want more walkable cities.

Persistent mirusvirus infection in the marine protist Aurantiochytrium www.nature.com/articles/s41...

Multiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific activity journals.asm.org/doi/10.1128/...

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

Our new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Congrats to the Blue Jays. I’m going to sulk for a few days but what an amazing season for the @mariners.com Proud of this team

Virus driven Disruption of Transcription Termination (DoTT) generated cellular Z-RNAs are bona fide ZBP1 ligands driving cell death as a host response to counter viral disruption of the cellular transcriptional machinery @nature.com @foxchasecancer.bsky.social www.nature.com/articles/s41...

🧬 Exciting news from our lab 🧬 The Swiss National Science Foundation (SNSF) has approved our project studying KSHV and RNA decay: our first grant since re-launching the lab in Switzerland 🎉 We’re now looking for a Postdoc and a PhD student to join the team (start date January 2026) - please repost!

I made a sign for the lab with our informal lab motto, inspired by this convo between @itaiyanai.bsky.social and Martin Lercher: nightscience.buzzsprout.com/1744020/epis.... A good reminder that talking is among the best forms of thinking!

In new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2. Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion. www.biorxiv.org/content/10.1...

Collaborative study with Kharpeskyy lab @dalhousieu.bsky.social + our lab @ulethbridge.ca (under review) shows: sequence features—not secondary structure—of 5′ UTRs give viral & cellular mRNAs resistance to SARS-CoV-2 Nsp1 host shutoff. www.biorxiv.org/content/10.1...

i love you hubble

Giant virus endogenization in Acanthamoeba we covered more in detail in a separate manuscript published some weeks ago in @bmc.springernature.com Biology, in a great collaboration with John Archibald's group at Dalhousie: bmcbiol.biomedcentral.com/articles/10..... 6/7

Crab-like creatures are famed for having evolved five times in evolutionary history. But anteaters have evolved at least 12 times--in half the evolutionary span. Cool story by @jakebuehler.bsky.social for @science.org

Huge congratulations to Dr. Emma LeBlanc on her successful PhD thesis defence yesterday! As my first PhD student, Emma was instrumental in getting my lab up and running, in the midst of a pandemic, while managing to be very productive and do some exciting science along the way! #proudPI

Finally out! I’m thrilled to share our new paper (Wolin et al., Cell 2025). This paper describes SPIDR, a high-throughput method for mapping RBP binding sites. By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.

It’s too late to save these lost young lives in Texas, but not too late to avert the next tragedy that could be fully avoided. It’s one thing to say you’re making things more efficient and quite another to gut something essential with no replacement. Turn the f’ing lights back on! /fin

'The myth of meritocracy in science collapses under the financial sacrifices expected at every career stage. From unpaid internships and self-funded conferences to underpaid graduate and postdoctoral positions, the hidden costs of ‘doing science’ are profound.' journals.plos.org/plosbiology/...

💥 Couldn’t be more stoked our study identifying a completely new CMV virion surface complex involved in cell entry is now published at Nature Micro 🦠 H/T @paramyxologist.bsky.social + Lauren Henderson, Erica Ollmann Saphire Chris Benedict @natmicrobiol.nature.com www.nature.com/articles/s41...

New CRISPR technology developed by @stanleyqilab.bsky.social‬, Mengting Han & team could pave the way for potential treatments for neurodegenerative diseases like ALS and spinal muscular dystrophy:

Nature research paper: Probing condensate microenvironments with a micropeptide killswitch https://go.nature.com/4mMlGyc

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

2nd is the brilliant preprint of @corcoranlab.bsky.social & @rorymulloy.bsky.social. It’s a deep dive into all things N*, & every other paragraph drops some new, delightful discovery. www.biorxiv.org/content/10.1... 15/34

…prompted me to take a closer look, and for reasons I’ll describe below, I now believe rumors of N*’s death are exaggerated. First, XEC is in terminal decline, replaced by variants with full N* expression, so N* is back in fashion. 3/34 journals.plos.org/plosbiology/...

SGs can form as a response to dsRNA detection, but when Mulloy induced SG formation via a dsRNA-independent pathway, N* still stopped SGs. Mutation of two essential AA for dsRNA binding (K257, K261) showed that N*’s dsRNA binding was required for SG antagonism. 23/34

An awesome preprint on the novel, unsung SARS-CoV-2 N* protein came out recently, authored by @corcoranlab.bsky.social and @rorymulloy.bsky.social. I’ve previously written on N*’s demise in XEC, the top variant for several months, but… threadreaderapp.com/thread/18373... 1/34

If people of means are interested in establishing a 2025 “Institute for Advanced Study” for displaced/defunded biomedical scientists, I know many people who will help, including myself. @mcuban.bsky.social @arcadiascience.com @arcinstitute.org

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

The parasitic larvae of a wasp inject a virus into their caterpillar hosts that makes the caterpillars aggressive and even cannibalistic when food is scarce, increasing the odds that the parasites and their hosts will survive. In PNAS: www.pnas.org/doi/10.1073/...