Noga Sharlin
@nogasharlin.bsky.social
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PhD student at the University of Calgary Studying human coronaviruses in the Corcoran Lab
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Noga Sharlin
Nature Microbiology
3 months ago
The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition By Dustin Glasner, Matthew Daugherty & colleagues.
#microsky
www.nature.com/articles/s41...
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The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition - Nature Microbiology
Viruses generally have compact genomes, resulting in many viral mRNAs with short 5’ untranslated regions. An antiviral complex exploits this feature of viral mRNAs to selectively inhibit viral protein...
https://www.nature.com/articles/s41564-025-02138-w
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Noga Sharlin
Ryan Hisner
7 months ago
An awesome preprint on the novel, unsung SARS-CoV-2 N* protein came out recently, authored by
@corcoranlab.bsky.social
and
@rorymulloy.bsky.social
. I’ve previously written on N*’s demise in XEC, the top variant for several months, but…
threadreaderapp.com/thread/18373...
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Noga Sharlin
Indra_Beķere
7 months ago
Our manuscript on dsRNA sensor OAS2 from the lab of
@oliveiramann.bsky.social
is now out in
@cp-molcell.bsky.social
! Thanks again to the whole team for their effort putting this story together!
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Noga Sharlin
Emily Bruce
8 months ago
Very happy that this story is now published in
@plosbiology.org
. It includes lots of additional data, (creation of the G215S mutant) & demonstrates the increased growth/ oligomerization of N is specific to the cysteine at 215. Thanks to the coauthors, reviewers and editors who helped improve it!
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Noga Sharlin
Chris Sullivan
9 months ago
Previously, KO and overexpression showed host RNA 5’ triphosphatase DUSP11 can reduce RIG-I sensitivity. Here, we show poxviruses code for viral DUSP11 that can regulate host RNP III transcripts and RIG-I, providing evolutionary support DUSP11 can be pro-viral.
journals.plos.org/plospathogen...
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Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses
Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1013101
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Noga Sharlin
Emmanuelle Genoyer
9 months ago
Check out this fun preview of my postdoctoral work! It highlights our findings plus lots of intriguing questions that I’m super excited to tackle in the coming years. (And the model is beautiful! Thank you! 🧑🎨 )
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Noga Sharlin
Nature
10 months ago
After 150,000 articles and 17 million genome sequences, what has science taught us about SARS-CoV-2?
https://go.nature.com/4iDKrtw
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Four ways COVID changed virology: lessons from the most sequenced virus of all time
After 150,000 articles and 17 million genome sequences, what has science taught us about SARS-Cov-2?
https://go.nature.com/4iDKrtw
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reposted by
Noga Sharlin
Corcoran Lab
10 months ago
Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies.
www.biorxiv.org/content/10.1...
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A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
https://www.biorxiv.org/content/10.1101/2025.02.15.638421v1
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