Corcoran Lab
@corcoranlab.bsky.social
๐ค 157
๐ฅ 243
๐ 6
she/her Molecular virologist and Associate professor at the University of Calgary, Canada.
pinned post!
journals.plos.org/plosbiology/...
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Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003646
17 days ago
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18
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reposted by
Corcoran Lab
Ed Hutchinson
17 days ago
Do you like microscopy? Do you think viruses are cool? Do you want to advance our understanding of one of the world's most important pathogens? Come and do your PhD with myself and the fantastic
@peacockflu.bsky.social
, at
@pirbrightinst.bsky.social
and
@cvrinfo.bsky.social
๐ค๐ฆ ๐
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FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow, listed on FindAPhD.com
https://www.findaphd.com/phds/project/fully-funded-phd-visualising-avian-influenza-virus-tropism-and-co-infection-in-avian-hosts/?p196037
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reposted by
Corcoran Lab
PLOS Biology
17 days ago
#SARSCoV2
has optimized its replication fitness in the human host.
@rorymulloy.bsky.social
@corcoranlab.bsky.social
&co show that a
#nucleocapsid
gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing
#antiviral
responses
@plosbiology.org
๐งช
plos.io/3PIZMjr
0
11
1
reposted by
Corcoran Lab
Ed Hutchinson
17 days ago
Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between
@cvrinfo.bsky.social
and
@pirbrightinst.bsky.social
Details in the thread below - please share! Deadline 8th May 2026, fully funded for UK Home students (1/4)
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20
reposted by
Corcoran Lab
Rory Mulloy
17 days ago
๐ฅ Paper published ๐ฅ Curious how
#SARS2
has changed since jumping into humans? We were too!
journals.plos.org/plosbiology/...
๐งต ๐งต ๐งต
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Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003646
2
9
10
reposted by
Corcoran Lab
Noga Sharlin
17 days ago
So proud to have worked alongside
@rorymulloy.bsky.social
and
@corcoranlab.bsky.social
on this amazing project, now out in
@plosbiology.org
!
journals.plos.org/plosbiology/...
loading . . .
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003646
0
5
1
reposted by
Corcoran Lab
PLOS Biology
17 days ago
#SARSCoV2
has optimized its replication fitness in the human host.
@rorymulloy.bsky.social
@corcoranlab.bsky.social
&co show that a
#nucleocapsid
gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing
#antiviral
responses
@plosbiology.org
๐งช
plos.io/3PIZMjr
0
13
4
journals.plos.org/plosbiology/...
loading . . .
Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses
SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003646
17 days ago
2
18
9
reposted by
Corcoran Lab
Nature Reviews Molecular Cell Biology
6 months ago
New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
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Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
Nature Reviews Molecular Cell Biology, Published online: 06 October 2025; doi:10.1038/s41580-025-00895-4Co-transcriptional mRNA maturation is a complex, multistep process. This Review focuses on how the development of long-read sequencing methods enabled investigating the timing, coordination and outcomes of alternative uses of transcription start sites, splice sites and polyadenylation sites and their disease implications.
https://bit.ly/4gWN4ah
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reposted by
Corcoran Lab
Joseph Luna
about 1 year ago
This is an incredibly moving thread.
add a skeleton here at some point
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reposted by
Corcoran Lab
Stephen Graham's Lab
about 1 year ago
The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study
#Oropouche
virus, (probably) the most important virus that youโve never heard of:
doi.org/10.1101/2025...
Bluetorial follows ๐ฆ๐งต
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Protein-based tools for the detection and characterisation of Oropouche virus infection
Oropouche fever is a neglected tropical viral disease endemic to Latin America and the Caribbean. Oropouche fever is caused by Oropouche virus (OROV), an orthobunyavirus with a tri-segmented (-)ssRNA ...
https://doi.org/10.1101/2025.02.26.25322767
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reposted by
Corcoran Lab
Jeremy Kamil
about 1 year ago
@rorymulloy.bsky.social
et al illuminate mechanism rewarding evolution of novel transcriptional start sites in SARS-CoV-2 during its adaptation to humans ๐. From:
@corcoranlab.bsky.social
www.biorxiv.org/content/10.1...
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A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
https://www.biorxiv.org/content/10.1101/2025.02.15.638421v1
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reposted by
Corcoran Lab
Rory Mulloy
about 1 year ago
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the
@corcoranlab.bsky.social
with
@nogasharlin.bsky.social
, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran
www.biorxiv.org/content/10.1...
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Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies.
www.biorxiv.org/content/10.1...
loading . . .
A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
https://www.biorxiv.org/content/10.1101/2025.02.15.638421v1
about 1 year ago
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