Corcoran Lab
@corcoranlab.bsky.social
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she/her Molecular virologist and Associate professor at the University of Calgary, Canada.
reposted by
Corcoran Lab
Nature Reviews Molecular Cell Biology
3 months ago
New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
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Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods
Nature Reviews Molecular Cell Biology, Published online: 06 October 2025; doi:10.1038/s41580-025-00895-4Co-transcriptional mRNA maturation is a complex, multistep process. This Review focuses on how the development of long-read sequencing methods enabled investigating the timing, coordination and outcomes of alternative uses of transcription start sites, splice sites and polyadenylation sites and their disease implications.
https://bit.ly/4gWN4ah
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Corcoran Lab
Joseph Luna
10 months ago
This is an incredibly moving thread.
add a skeleton here at some point
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Corcoran Lab
Stephen Graham's Lab
10 months ago
The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study
#Oropouche
virus, (probably) the most important virus that you’ve never heard of:
doi.org/10.1101/2025...
Bluetorial follows 🟦🧵
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Protein-based tools for the detection and characterisation of Oropouche virus infection
Oropouche fever is a neglected tropical viral disease endemic to Latin America and the Caribbean. Oropouche fever is caused by Oropouche virus (OROV), an orthobunyavirus with a tri-segmented (-)ssRNA ...
https://doi.org/10.1101/2025.02.26.25322767
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Corcoran Lab
Jeremy Kamil
10 months ago
@rorymulloy.bsky.social
et al illuminate mechanism rewarding evolution of novel transcriptional start sites in SARS-CoV-2 during its adaptation to humans 👀. From:
@corcoranlab.bsky.social
www.biorxiv.org/content/10.1...
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A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
https://www.biorxiv.org/content/10.1101/2025.02.15.638421v1
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Corcoran Lab
Rory Mulloy
10 months ago
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the
@corcoranlab.bsky.social
with
@nogasharlin.bsky.social
, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran
www.biorxiv.org/content/10.1...
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Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies.
www.biorxiv.org/content/10.1...
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A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses
Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...
https://www.biorxiv.org/content/10.1101/2025.02.15.638421v1
10 months ago
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