Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...

The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41... The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

🚨Publication alert🚨 My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

Microtubule lattice conformation and integrity regulate α-tubulin acetylation https://www.biorxiv.org/content/10.1101/2025.09.09.675099v1

Our humble gata2b in situ hybridization image made it onto the cover of @biologyopen.bsky.social! If you'd like to check out the story behind the image, the link to our new paper is: journals.biologists.com/bio/article/...

Geng, @kjverhey1.bsky.social et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors rupress.org/jcb/article/...

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

🔎New preprint! We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture. Big thanks to @ivanagasic.bsky.social and team! Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5) www.biorxiv.org/content/10.1...

📢 Deadline extended to Join Arolla 2025! 📅 Aug 25–29, Grand Hotel, Arolla 🌍 For junior & senior scientists in cutting-edge bio research 🧬 Abstracts + reg close August 11 💸 Discounts for LS2 members! 👉 Info & reg: meetings.ls2.ch/arolla2025

Designed protein pockets recognize intrinsically disordered protein regions @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... www.statnews.com/2025/07/17/n...

How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi! www.cell.com/current-biol...

New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations. The tissue morphogenesis logic, now engineered into living, programmable materials. www.biorxiv.org/content/10.1... #ActiveMatter #TissueEngineering

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩 www.nature.com/naturecareer...

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint! www.biorxiv.org/content/10.1...

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes. More info: www.nature.com/naturecareer... Apply by 10 JUL #ScienceJobs

🤩 Last week I successfully defended my PhD! It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words! Huge thanks to my jury members for the thoughtful feedback and conversations. @soldatilab.bsky.social

🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM www.biorxiv.org/content/10.1...

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

Latest paper from the lab @cellbiol-mrclmb.bsky.social, Anna's PhD work hot off the press @plosbiology.org ! Using single cell genomics to understand tube morphogenesis, and why it's as important to switch things off as it is to switch them on!

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi @ipparis.bsky.social @polytechniqueparis.bsky.social

Excited to announce the Molecular Biology of Archaea (MBoA) 2026! Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.

A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt

In our latest interview, we hear from the 2024 @bscb-official.bsky.social Hooke Medal winner Emmanuel Derivery @deriverylab.bsky.social. Emmanuel tells us about his research, what winning the Hooke Medal means to him & his advice on building a successful lab. journals.biologists.com/jcs/article/...

Join Adam's Lab! He is an amazing scientist and the project is so cool!

Congratulations to Dr. @guallar-garrido.bsky.social on her new lecturer position at the Autonomous University of Barcelona! She will keep working on mycobacteria using amoeba host model. Best of luck on this exciting new chapter! 👏🔬✨

We're on a roll!🚀 Check our latest research @naturecomms.bsky.social: rdcu.be/ecXzr We reveal how mosaic MTs faithfully mimic the GTP cap, highlighting lattice expansion (not pf twist) as the structural cornerstone of MT stability and dynamic instability. Congrats to Juan and everybody involved! 🎉

We present: Direct-view oblique plane microscopy www.biorxiv.org/content/10.1...

New: Colombo et al. @surreylab.bsky.social show that NuMA is a mitotic dynein adaptor that binds and caps microtubule minus ends, explaining how dynein, NuMA, dynactin, and Lis1 focus microtubule minus ends at mitotic spindle poles https://buff.ly/41aj9F9

Extremely happy to see our work finally out!🎉 Great collaboration between @rouxlab.bsky.social @buzzbaum.bsky.social labs and a real pleasure to work and share co-first authorship with incredible scientists and friends @diorgeps.bsky.social @sami-c.bsky.social. Big thanks to the rest of the authors!

Finally out! 🎉 Really happy to share my first co-author paper! It was wonderful to work with @aliperri.bsky.social , and huge thanks to @xaviertrepat.bsky.social for the opportunity to be part of this project. Grateful to the whole team for making this happen! www.nature.com/articles/s41...

Join our Structural Studies Division, leading a research group developing computational methods to address questions in molecular & cellular biology! You will be supported by core funding, excellent facilities & enthusiastic colleagues. Apply by 18 MAR www.nature.com/naturecareer...

Congratulations to @lara-kruger.bsky.social, postdoc in @deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social, who is leaving the LMB to establish her own research group at @institutcurie.bsky.social in Paris! Best of luck to you Lara! #LMBAlumni

1/11 🚨 New research! 🚨 We explored how cells adhere to supported lipid bilayers (SLBs) using Invasin, a high-affinity integrin ligand. Surprisingly, cells spread and form mature integrin adhesions on fluid SLBs, revealing a novel microtubule-driven mechanotransduction! www.nature.com/articles/s41...

New paper alert! ‼️‼️ Super happy to share that my postdoc paper is finally out! 1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.

Our automatic parameter-free deconvolution code is now 2–3× faster while still producing exactly the same results as before. If you want to try it out, we have a Google Notebook implementation available at beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/. Manuscript WIP.

Congrats to @juliemiesch.bsky.social who was awarded a Postdoc Mobility grant by @snf-ch.bsky.social to support her research for two years. Her postdoc research will focus on the biophysical regulation of water buffering in the cell.

Very happy to have been awarded this grant to pursue my postdoc ! 😁

Yamini @yamini-ravichan.bsky.social changed the topology of Hydra to show that actin orientational defects of Hydra induce the full program of head regeneration: www.science.org/doi/10.1126/... Mechanics controls development! Thanks to Dan Pearce, Karsten Kruse, Matthias Vogg & Brigitte Galliot.

🚨 Paper Alert 🚨 Our preprint describing Elongator as a selective microtubule polymerase that rewrites PTMs on microtubules is now published! Check it out: www.embopress.org/doi/full/10....

How does tRNA-modifier #Elongator stabilize microtubules during asymmetric cell division? Vicente Planelles Herrero @deriverylab.bsky.social et al find subcomplexes binding to microtubule ends & tubulin dimers, & enriching microtubules with polyglutamylated tubulin www.embopress.org/doi/full/10....

Congrats to @akaashkumar.bsky.social who has won the PhD Award from the Cambridge Centre for Physical Biology for his work developing a novel microscopy system with @deriverylab.bsky.social & @jamesdmanton.bsky.social in @cellbiol-mrclmb.bsky.social. www.physbiol.cam.ac.uk/akaash-kumar #LMBintheNews

Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos. Read more about the role here: www.nature.com/naturecareer... Apply by 30 DEC #ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering

BTW we‘ve recently released an improved version of our manuscript uncovering the assembly mechanism of microtubules via intermediate clusters of protofilaments! @maksimkalutskii.bsky.social @vladimirvolkov.bsky.social @compbiophys.bsky.social 👇👇👇 doi.org/10.1101/2024...

Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)

Honored to be the recipient of the GSV Prize 2024 for my thesis on +TIP phase separation in the Aumeier lab at the University of Geneva ☺️

There's just over a fortnight left to apply to the LMB's PhD programme, which features a veritable smörgåsbord of projects (including one of our own on engineering the next generation of fluorescent proteins for live and super-resolution microscopy). www2.mrc-lmb.cam.ac.uk/students/int...