Histone acetylation - not always about transcriptional activation: H4K16ac safeguards the genome replication program by repressing premature replication of heterochromatin. Well done Marta Milan! tinyurl.com/yuy9m8t3

Our latest paper, my 9th in one of my favourite journals @narjournal.bsky.social - transcriptional cofactors don’t just help in gene activation, they also help guide their partner transcription factors to target genes academic.oup.com/nar/article/... ##zincfingers #chromatin #epigenetics #KLF

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

A purpose built solution to Australia’s biomedical funding crisis….. release the #MRFF = invest in our future scientists & their discoveries. #DiscoveriesNeedDollars www.smh.com.au/politics/fed...

Seven years. Over 400 pages. About 750 references. Over 40 figures. Finally I get to hold the finished book. It’s a big day. #EpigeneticsBook @cshlpress.bsky.social

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇

Really enjoyed reading the new @lucagiorgetti.bsky.social lab preprint that makes the case that not all E-P interactions are created equal - it is the subset of long-lived extrusion-mediated E-P interactions that are most transcriptionally important: www.biorxiv.org/content/10.1...

@cincyresearch.bsky.social @jclinical-invest.bsky.social Allergen-Specific mRNA-Lipid Nanoparticle Therapy for Prevention and Treatment of Experimental Allergy in Mice www.jci.org/articles/vie...

Interesting in aging, immune function, and organ health? Join us for a super exciting joint Keystone Symposia in Banff, Canada in March 2026!! @ericverdin.bsky.social

Just been reading this nice review. Taught someone who has never really done developmental biology a lot! Thanks and congrats to all involved. #epigenetics

New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan. www.biorxiv.org/content/10.1...

Red blood cells are analysed inside a lab-on-a-chip, a tiny device that condenses the complexity of a lab into postage-stamp size. Researchers are using these to tackle malaria with speed and precision. See the #ArtOfScience gallery: www.wehi.edu.au/art-of-scien...

Perspective @cp-immunity.bsky.social A roadmap for defining “extrafollicular” B cell responses www.cell.com/immunity/ful... @stephanieeisen.bsky.social @vinuesalab.bsky.social et al

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪 A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today! #InHoxWeTrust

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

Speaker Spotlight: Don’t miss @Anders_S_Hansen from MIT as he unpacks the secrets of distal gene regulation in space and time! Learn how enhancers find and activate their target genes—revealing new insights into the selectivity and dynamics of gene control. Reserve your seat:

1/ One of the questions I get asked about my book is what new they'll discover about #epigenetics. I hope there will be a lot to learn, but maybe one of the most intriguing stories will be about the contribution of John Pugh. www.amazon.com/Epigenetics-...

Big news! The Snow Centre for Immune Health welcomes our new Director, globally renowned coeliac research leader, Associate Professor Jason Tye-Din. Learn more: www.wehi.edu.au/news/new-dir... #ImmuneHealth #MedicalResearch #Leadership #SnowCentre #WEHI #RMH

1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

Most read, I hear! Here is your chance to read what @mariekeoudelaar.bsky.social and I had in mind when writing this together.

[Commentary] Distal enhancers loop to proximal enhancers, not to promoters by the one and only Kevin Struhl in #genesky @natrevmcb.nature.com www.nature.com/articles/s41...

🎓 Applications are now open for WEHI’s International PhD Scholar Initiative. 📅 Apply by Sunday 26 October 2025 🔗 Learn more about eligibility, scholarships and how to apply: wehi.edu.au/education/ph... Help us spread the word by sharing with your networks!

While I was taking a holiday last week, 2 super exciting preprints dropped, adding to another posted 6 days prior. These papers describe a remarkable role for *recessive* variants in *RNU2-2* causing developmental and epileptic encephalopathy 🧵 by the amazing @christeldepienne.bsky.social 👇 1/3

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

Check out @annaamonaco.bsky.social piece on our recent story 🧬🦠 ✋🏻 & have a look at her website, Anna is an amazing science communicator and writes about discoveries on the non-coding “dark” genome! Thank you for highlighting our work 🤩

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works. 🔗 www.wehi.edu.au/news/eureka-...

Earlybird registration & abstract submissions now open for the 𝟒𝟕𝐭𝐡 𝐋𝐨𝐫𝐧𝐞 𝐆𝐞𝐧𝐨𝐦𝐞 𝐂𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞, 𝟏𝟓-𝟏𝟖𝐭𝐡 𝐅𝐞𝐛 𝟐𝟎𝟐𝟔: https://www.lornegenome.org/registrations (deadline 7th Nov 2025) Speakers: https://www.lornegenome.org/speakers We look forward to seeing you there!

Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant hematopoiesis. www.cell.com/trends/cance...

Dreg1 is a Tcf1-dependent non-coding RNA critical for fine tuning the high level of Gata3 required for the optimal development of the ILC2 lineage @biorxivpreprint.bsky.social @rhyscienceallan.bsky.social www.biorxiv.org/content/10.1...

I am excited to share our latest study by Sara Quon in collaboration with @ajithvasanthan.bsky.social entitled “The lncRNA Dreg1 is required for optimal ILC2 development” www.biorxiv.org/content/10.1...

A landmark research milestone, from a brilliant collaborative team, published in @natmed.nature.com 🔗 www.nature.com/articles/s41... @sarahannbest.bsky.social @saskiafreytag.bsky.social tag.bsky.social @jimwhittle.bsky.social

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗 🦟 Transgenic parasites without Pfs230 D13D14 do not transmit 🦙 💉Nanobodies + mRNA induced antibodies reduce transmission New in @Science.org www.science.org/doi/10.1126/... #ScienceResearch #Malaria #WEHI

Join us this week👇👇👇

NEXT WEEK ❤️👇🧬

Very happy that this (last?) piece of my PhD time in the Dekker lab is now out in Genome Research! genome.cshlp.org/content/earl... @jobdekker.bsky.social @pablonavarrolab.bsky.social @genomeresearch.bsky.social

Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually. www.nature.com/ng/volumes/5...

We're hiring! Need a microscopy wizard to help build the world’s first synthetic plant chromosome! Bring your lights, lasers, & lens-craft to characterise new artificial chromosomes. Join our ARIA-funded project at UWA in Perth & ‪@plants4space.bsky.social‬. Apply: bit.ly/3GKSRSA

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

New research: MCL-1 not only prevents cell death, also fuels cells by supporting energy production. Helps explain side effects seen with MCL-1 targeting drugs in cancer clinical trials; could lead to better therapies. In @science.org 🔗 www.wehi.edu.au/news/hidden-...

Beautiful 🤩 👏👇

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

It’s a GOA for July! Please join us for what promises to be an amazing 🤩 seminar 👇

Very smart way to distinguish between eu/heterochromatin for single nucleosome tracking. "Replication-dependent histone labeling dissects the physical properties of euchromatin/heterochromatin in living human cells" From @kazu-maeshima.bsky.social lab www.science.org/doi/10.1126/...

These Curie courses are great. Highly recommend!

How does (local #DNA) structure affect (3D #genome) structure? Can mutating G4s abolish #enhancers key for #blood function? In the second part of our explorations of #G4s in gene regulation, we show how abolishing G-quadruplex structures in the genome disrupts enhancers. 1/9 doi.org/10.1186/s130...