New research from Peter Mac has uncovered further evidence of how pregnancy triggers a powerful, long-lasting immune response in the breast, opening the door to potential new ways to prevent #breastcancer in people at high risk. Read more: petermac.org/about-us/new...

Massive congratulations to @ajithvasanthan.bsky.social, @t-hussain.bsky.social, and everyone else involved. An equally amazing and important discovery.

I’m excited to share our latest study, published today in @natimmunol.nature.com. It is long known that pregnancy reduces the risk of developing breast cancer, yet the biological mechanisms underlying this protection have remained largely unknown. Read the paper here: www.nature.com/articles/s41...

This has been a great collaboration between @ajithvasanthan.bsky.social lab and mine @wehi-research.bsky.social led by Sara Quon and Adelynn Tang! Thanks to @elife.bsky.social editors and peer reviewers for the constructive process!

Excited to share the final version of our paper with @ajithvasanthan.bsky.social @petermaccc.bsky.social on the gene we discovered, Dreg1 @elife.bsky.social Here we probe a novel knockout to identity a specific role for Dreg1 in group 2 ILC development elifesciences.org/articles/109...

Pleased to collaborate with @rhyscienceallan.bsky.social @wehi-research.bsky.social on this exciting study exploring the function of the lncRNA Dreg1, published in @elife.bsky.social. We found that Dreg1 is critical for ILC2 development. @petermaccc.bsky.social elifesciences.org/reviewed-pre...

Excited to start the new year with our collaborative paper with @ajithvasanthan.bsky.social being published @elife.bsky.social -check it out! elifesciences.org/reviewed-pre...

A very fast moving area: we now have more post-CDK4/6 options than clear biological principles for choosing among them. Looking forward to discussing this at #SABCS25 @sabcs.bsky.social @elmayermd.bsky.social

Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

Thrilled to make the cover of @natimmunol.nature.com this month. A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social

Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability @sciimmunology.bsky.social www.science.org/doi/10.1126/...

I am excited to share our latest study by Sara Quon in collaboration with @ajithvasanthan.bsky.social entitled “The lncRNA Dreg1 is required for optimal ILC2 development” www.biorxiv.org/content/10.1...

NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models @nature.com @paulbeavis4.bsky.social www.nature.com/articles/s41...

Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL @petermaccc.bsky.social is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY! www.nature.com/naturecareer...

I am so excited to share our new publication on Nature Metabolism about the metabolic reprogramming in gamma delta T cells in response to inflammation. #gdt #immunometabolism Thanks for my research team in groups of @timsparwasser.bsky.social in Germany and Princeton @lydialynch.bsky.social 🙌🏻

CCR8+ decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy | Science Immunology www.science.org/doi/10.1126/...

Our paper is out! LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

Someone awesome in my circle shared some terrific news with me today but was hesitant to do so because of all that is going on in the science world. It may appear insensitive that you are celebrating when other colleagues are struggling but I entreat you to celebrate & share good news. 1/

If any American immunologists want to write an op-ed for @immunolcellbiol.bsky.social on the impact of the new executive orders, please contact me

Very excited about this collaborative study between @petermaccc.bsky.social @danielutzschneider.bsky.social and Kallies lab

Cool new study from the lab of my friend and collaborator @danielutzschneider.bsky.social in #ScienceImmunology showing that a common ID3+ precursor gives rise to stem-like memory and Tpex cells. Congrats to everyone involved!! @rickyjohnstone.bsky.social @petermaccc.bsky.social @onjcri.org.au

@ozsinglecell.bsky.social #OzSingleCell25 has a new website www.ozsinglecell.com See the current list of invited speakers and stay tuned for registration details. Sponsors reach out to [email protected]

Exciting new study from the Mathis group showing the features and functions of meningeal Tregs now in Science Immunology!!@https://www.science.org/doi/10.1126/sciimmunol.adu2910n

Tour de force! @metorrespadilla.bsky.social & team develop Smart-seq+5′ to map TSS in single embryos with unprecedented res revealing plethora of TE-driven transcripts in 5 mammal species. Some surprisingly old & conserved. Treasure trove of new biology for yrs to come! www.cell.com/cell/fulltex...

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP www.science.org/doi/10.1126/...

Here is link to Shixin's new paper: www.science.org/doi/epdf/10....

The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain) www.science.org/doi/10.1126/...

Jobortunities: Shortly advertising for 2 positions, both working on the Breast Cancer Atlas, in Sydney. - Wet lab research assistant: mol bio +/- pathology desirable - Comp. Research Assistant: scRNA-Seq, spatial transcriptomics and ML Details to follow, DM or email if you are a great fit.

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

Remodeling of Il4-Il13-Il5 locus underlies selective gene expression www.nature.com/articles/s41...

We have a new position for a bioinformatician / computational biologist exploring genomic and epigenomic features of #cfDNA to uncover new cancer biology. careers.petermac.org/job/MELBOURN...

Peter Mac is excited to join BlueSky! 🦋 We look forward to sharing ideas, fostering positivity, and connecting with you all as we work together to advance cancer care and research. Let’s inspire, collaborate, and make a difference!

Latest preprint from the lab! Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish www.biorxiv.org/content/10.1...

Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!