Merlin Crossley
@merlincrossley.bsky.social
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Lecturer, researcher in CRISPR gene editing, epigenetics etc, and university administrator
www.nature.com/articles/s41...
Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease
#crispr
#epigenetics
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Removal of promoter CpG methylation by epigenome editing reverses HBG silencing - Nature Communications
DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening...
https://www.nature.com/articles/s41467-025-62177-z
11 days ago
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Came across a plant with many 4 and 5 leaf clovers. Is this common?
#4leafclovers
#fourleafclovers
#5leafclovers
11 days ago
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Several friends urged me to write about the non-Dire Wolves, so I have. But my piece is really about the fact that you can trust the process of science but not individuals or teams. Loyalty to teams is a major factor that causes misinformation to persist:
crossleylab.wordpress.com/2025/04/28/2...
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Non-Dire Wolves and the Process of Science
Science works but it requires unwavering adherence to a system. The pollution that is misinformation is science’s enemy. As G.K. Chesterton said “If you leave a white post alone it will soon …
https://crossleylab.wordpress.com/2025/04/28/2164/
5 months ago
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Like the leaves that fall from the trees, such are the generations of men
5 months ago
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The UNSW Bilby has dressed up for Easter
5 months ago
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I’ve never noticed this before but it looks like I’ve been living near the house of the dragon
5 months ago
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“[If] it looks like a dire wolf and acts like a dire wolf, I'm going to call it a dire wolf,” Beth Shapiro, Colossal's chief science officer, told Wired. Oh no - I think my dog might be a Dire Wolf!
5 months ago
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Across Australia the amount of black on the back of Magpies varies dramatically. In Sydney their backs are almost completely black.
6 months ago
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Friday is blog day at
#UNSW
Today the Woolly Mouse but this is more a comment on the different pressures in public and private research and different leadership styles - big visions versus realistic plans
#woollymammoth
#leadership
#universities
#biotech
crossleylab.wordpress.com/2025/03/22/t...
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To deal in hope – the Woolly Mouse
Having big goals can be inspiring. Napoleon famously quipped “A leader is a dealer in hope.” He urged his people to aim for the impossible to achieve the maximum. Apparently, this is effectiv…
https://crossleylab.wordpress.com/2025/03/22/to-deal-in-hope-the-woolly-mouse/
6 months ago
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Good to know that Tawny Frogmouths are still in the neighbourhood
7 months ago
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Urban fossils: elm and beech, Canberra
7 months ago
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Possums are great. Australia has such wonderful urban wildlife. You just have to be a little nocturnal to really appreciate it though!
7 months ago
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Birds are very comfortable on the UNSW campus. The ibis looks like it’s about to deliver a lecture!
8 months ago
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Some people think that in the modern age art is dead. But behold, it’s thriving on the street of Inner West neighbourhoods in Sydney
9 months ago
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We found these eggs 6 weeks ago - and now all 14 have hatched into cute little stink bugs.
#insects
in Australia
9 months ago
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It’s amazing how much variation there is in frangipani flowers - in our neighbourhood in Sydney it’s considered the pinker the better
9 months ago
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The authorities have stepped in to support and prop up this tree - the only problem is I think it’s one of those weeping varieties so all efforts may be in vain
9 months ago
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Street art in Parramatta
9 months ago
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This type of public clock is all you need - 6 hours and one hand, providing enough information for most occasions
9 months ago
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An Eastern Water Skink gingerly welcomes the New Year in Sydney
9 months ago
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Tis the time to be merry
9 months ago
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Xmas in Sydney
9 months ago
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Natural Christmas decorations in Sydney
9 months ago
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Christmas in Australia
9 months ago
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Happy Xmas everyone
9 months ago
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Thou shalt not pass - St Andrew’s Cross spider, celebrating Christmas in Sydney
9 months ago
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you reached the end!!
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