Thrilled to see this new preprint from Rupprecht lab out — happy I could contribute with my rotating rings. May the science keep spinning. 🔄✨

💡 Have you ever wondered how #circulating #tumor cells squeeze through narrow #capillaries during hashtag#metastasis ? 💥 We did, check out our latest publication just out #NatureMaterials: rdcu.be/eZHxJ

My PhD work showed that vimentin is not only a passive marker of EMT, but plays an active role in collective migration, controlling the mechanics of epithelial leader cells. I am grateful to my supervisors, Rene-Marc & Benoit Ladoux, as well as to all the co-authors. www.biorxiv.org/content/10.6...

Interesting work here…

Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions | Science Advances www.science.org/doi/10.1126/...

How do cells adapt their volumes when they proliferate and form a multicellular mass in 3D? If you have wondered about this or work with 3D in-vitro systems, then you will be happy to read our paper now on bioRxiv! www.biorxiv.org/content/10.1... See the thread 🧵 below for more information.

Perspective @jcb.org by Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...

How do cells move, divide, & sense their surroundings? The answer lies in the cytoskeleton--and when it malfunctions, cancer & birth defects follow. @alushinlab.bsky.social at @rockefeller.edu is developing new tools to probe this tiny, dynamic cell scaffolding. www.rockefeller.edu/news/38446-h...

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains 1/ doi.org/10.1101/2025...

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids journals.biologists.com/dev/article/...

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia. @sreejithsanthosh.bsky.social biorxiv.org/content/10.1...

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics. Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri! www.biorxiv.org/content/10.1...

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Preprint alert! We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength. doi.org/10.1101/2025...

Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof Carsten Grashoff now provides insight into the molecular details underlying the formation of the connections between epithelial cells. #Biology

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob. www.biorxiv.org/content/10.1...

For #zebrafish people - we have a joint @ZDMSociety @InfoIzfs webinar focused on single-cell tech coming up on February 20th. Featuring Yinan Wan, Jialin Liu and Loic Royer. Register here: www.izfs.org/education/we...

Epithelial tension controls intestinal cell extrusion | Science www.science.org/doi/10.1126/...

Beautiful story that combined mechanobiology, evolution, and the power of fly (opto)genetics to make sense of the cephalic furrow. It was a pleasure writing the News & Views. No doubt this is still just the beginning for the field of mechano-evo-devo! Hats off to all involved

Tsai, T. Y. C., Garner, R. M., & Megason, S. G. (2022). Adhesion-based self-organization in tissue patterning. Annual review of cell and developmental biology, #EpithelialMechanicsReview www.annualreviews.org/content/jour...

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

Always nice to see the field moving forward! Paper out from the White lab in @nature.com today! www.nature.com/articles/s41.... #Microtubules conferring #mechanical resistance to compression in melanoma cells > similar to our findings in @natcellbio.nature.com doi.org/10.1038/s415... ☝️

Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026). For more information, please contact: [email protected]

We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter. 🔗 www.nature.com/articles/s41... #biophysics #syntheticcell #softmatter

Luciano, M., Tomba, C., Roux, A., & Gabriele, S. (2024). How multiscale curvature couples forces to cellular functions. Nature Reviews Physics, #EpithelialMechanicsReview www.nature.com/articles/s42...

Excited to share our new publication in Nature Physics about the mechanical memory of morphology in confined migrating cells by @kyohalie.bsky.social 🥳 Super fun collab with @davidbrueckner.bsky.social and @gcharras.bsky.social 👏🏻 Enjoy the reading www.nature.com/articles/s41...

New Article! Fibrous polyisocyanide hydrogels for 3D cell culture applications

Brandstätter, T., Brückner, D. B., Han, Y. L., Alert, R., Guo, M., & Broedersz, C. P. (2023). Curvature induces active velocity waves in rotating spherical tissues. Nature Communications, www.nature.com/articles/s41... #EpithelialMechanics

Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis pubs.aip.org/aip/apb/arti...

One of the key aspects influencing morphogenesis is mechanics. We mapped the mechanical properties of living roots at the tissue and cellular levels using Brillouin microscopy and molecular rotors. www.biorxiv.org/content/10.1...

Why would anyone want to be a scientist? url: journals.biologists.com/jcs/article/...

Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

New paper! We find that fast matrix stress relaxation potentiates human monocyte 3D migration by generating protrusive forces and is dependent on the Cdc42-WASp axis. Thanks to our amazing collaborators👏! #viscoelasticity #mechanobiology @stanford-chemh.bsky.social www.pnas.org/doi/10.1073/...

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025! Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

More on collective behavior: Our new Annual Review of Biophysics piece - with the stellar Danielle Chase - explores how animals sense, share information, and make group decisions. In honeybees and beyond 🐝 www.annualreviews.org/content/jour...

Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️

📣 Physics & Life 2025 - last month to register! 📅 October 2nd-3rd 📍Institut Jacques Monod, Buffon amphitheater Registration and abstract submission are open until September 5th 🔗 phys-life-2025.sciencesconf.org?lang=en @sfp-physique.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social

Cell tracking is never perfect, and it's important to understand the types of errors your solution contains. Here is my stab at this: Divisualisations in @napari.org. github.com/bentaculum/d... You spin tracks out upwards from the playing video. Green edges are correct, FP in magenta, FN in cyan.

Something we’ve been working on recently: soft PDMS micropatterned channels for traction force microscopy during confined migration. If you’re interested in seeing cells crawl through them while we measure traction forces take a look at our recent preprint! www.biorxiv.org/content/10.1...

Microinterfaces in bicontinuous hydrogelsguide rapid 3D cell migration https://www.biorxiv.org/content/10.1101/2023.09.28.559609v1

Cole Allan and Ovijit Chaudhuri discuss how the mechanical and structural properties of the extracellular matrix regulate diverse motility mechanisms across 2D and 3D environments. journals.biologists.com/jcs/article/...

3D Chemotaxis Chip for Investigating Natural Killer Cell Migration Mechanisms https://www.biorxiv.org/content/10.1101/2025.04.21.649825v1

3D hydrogel platform with macromolecular actuators for precisely controlled mechanical forces on cancer cell migration www.nature.com/articles/s41...

Cool review of experimental/computational/theoretical tools for studying cell migration in a data-driven fashion! arxiv.org/abs/2309.00545

Deciphering Pre-existing and Induced 3D Genome Architecture Changes involved in Constricted Melanoma Migration https://www.biorxiv.org/content/10.1101/2024.08.21.609017v1

Microinterfaces in bicontinuous hydrogelsguide rapid 3D cell migration https://www.biorxiv.org/content/10.1101/2023.09.28.559609v1

Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process https://www.biorxiv.org/content/10.1101/2024.07.25.605064v1

It is with infinite sadness that we learned of the passing of Clarisse Orniacki. She joined @vdoye.bsky.social lab and defended her thesis in December 2022 and pursued her career with a postdoc in‬ @tedfon.bsky.social at McGill University in Montreal . Tribute 🔗 www.ijm.fr/tribute-to-c...