Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

Super thrilled to see our review out! It was a great experience to put this together with @sameerthukral.bsky.social and @yuchiunwang.bsky.social. Use it as a primer to the field or as inspiration to brainstorm how rigidity transitions can bridge scales!

Final thanks to reviewers @amartinezarias.bsky.social @thibautbrunet.bsky.social & Cassandra Extavour and the editor @endofthepier.bsky.social. Quest for the mysteries of #cephalicfurrow and #Evolution_of_Morphogenesis continues (9/9) ‪

Our heroes: Bipasha Dey in my lab, Verena Kaul and @girishkalephd.bsky.social in Steffen's lab. PI search committees: be on the look out for Bipasha and Girish. They do wonders. But not after Bipasha does some additional cool things with Pavel. Stay tuned! (6/9)

Two distinct solutions, out-of-plane deformation and out-of-plane division, prevent mechanical instabilities. Our paper www.nature.com/articles/s41...; Pavel's and @bruvellu.bsky.social's with beautiful HCR in situ, lightsheet and @carldmodes.bsky.social's model www.nature.com/articles/s41... (5/9)

In Steffen's lab, @girishkalephd.bsky.social and Verena went out of their way to heroically sample much expanded range of fly phylogeny. #cephalicfurrow and lack there of split neatly along the divide of cyclorrhapha/non-cyclorrhapha. (4/9)

#cephalicfurrow forms and retracts to prevent tissue collision. Blocking it optogenetically not only causes buckling during #gastrulation, it also causes specific defects several hours after normal timeframe of retraction. More mysteries yet to be solved! (3/9)

Where to start? Beautifully concise, yet comprehensive N&V by @thibautbrunet.bsky.social www.nature.com/articles/d41... Essential reading from Pavel himself: tinyurl.com/4vurwar2 A thread of our bioRxiv from the other platform: tinyurl.com/46ceutx9 But read on for new stuff from revision! (2/9)

Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)