Hi bsky! How do cells coordinate fate with migration during development? 🐣 Turns out EMT doesn't just drive cell behaviour changes... it actively primes BMP signalling competence, creating a reciprocal coupling that drives collective invasion! (@bensteventon.bsky.social lab) tinyurl.com/2ncc8zap

We are excited to announce the first Eastern ☀️VGZT session for this season!✨🎉 📅Tomorrow, November 12th ⏰ 9:00 UTC / 9:00 GMT / 10:00 CET / 14:30 IST / 18:00 JST / 20:00 AEDT Our speakers are: 👉Sameer Thukral (on X: @SameerThukral6) 👉Axel Newton (on X: @AxelHNewton) See you on tomorrow☕️👋

Interested in polarity and mechanics during epithelial morphogenesis? Considering joining us! Students to be hired initially as Research Associates. Postdocs encouraged to obtain fellowship, and we help/train you to do that. Apply to tinyurl.com/y6x489t5. Deadline Dec 15. Please repost!

Excited to be traveling to meetings.embo.org/event/25-cyt... in Pune, India. Looking forward to seeing friends not seen in years and revisiting for the first time since 2020. My lab is recruiting. Those interested, let’s meet up there! (Look out for ads up here soon.)

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

Missing also @bipashadey29.bsky.social, but with @sameerthukral.bsky.social crashing the party, more than making up for it!

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More: www2.mrc-lmb.cam.ac.uk/john-gurdon-... #LMBNews

🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.

How nice! Mechanochemical feedback that shuts it self off below threshold. That is THE frontier of developmental mechanisms. Congrats!

Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social More info below ⬇️

Many thanks to @riken-bdr.bsky.social press team for publicizing our work.

A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis! Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)

Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨ “A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶 🔗 www.biorxiv.org/content/10.1... #devbio #biophysics 🧵⤵️

Super thrilled to see our review out! It was a great experience to put this together with @sameerthukral.bsky.social and @yuchiunwang.bsky.social. Use it as a primer to the field or as inspiration to brainstorm how rigidity transitions can bridge scales!

Thanks to @liamholt.bsky.social @fredchanglab.bsky.social for inspiration during the 2023 RIKEN symposium & @itaiyanai.bsky.social @nightsciencepod.bsky.social for encouraging us to blend day & night science,using a review not only to recap but also generate new perspectives!

From crowded cytoplasm to flowing tissues:how material properties changes across scales shaping development,especially during transitions? We provide primers on tissue scale & cytoplasmic rigidity,control parameters,new hypotheses on possible cross-scale feedback,linking scales rarely integrated.

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob. www.biorxiv.org/content/10.1...

A long-standing mystery in the development of fly embryos has been resolved go.nature.com/4nhVxaa

Nature research paper: Patterned invagination prevents mechanical instability during gastrulation go.nature.com/420lbIj

Nature research paper: Divergent evolutionary strategies pre-empt tissue collision in gastrulation go.nature.com/4m3exrU

Fascinating observations and beautiful physical modeling from our very own @tomokiishibashi.bsky.social and Tatsuo Shibata. Do check it out.

@bipashadey29.bsky.social we wouldn’t have pulled it off without you. So lucky to have you head our effort.

One of my all time favorite quotes, “Nothing in biology makes sense except in the light of evolution”, since the tender age of a skinny undergrad. (I’m still kind of skinny…) 🤣

Thanks so much, Juan. Steffen and I are very lucky to count you as our friend. We are rooting for you to bring #mechanobiology and #morphogenesis to the next level with #Brillouin microscopy and #proteomics with embryos.

We are excited to share our recent preprint on how tissue spreading guides extracellular matrix changes during early morphogenesis @gurdoninstitute.bsky.social

Forgot to tag @verenakaul.bsky.social. Verena’s following up on this brand new discovery of out of plane division, linking cell biology, tissue mechanics to evolution with Steffen. Stay tuned!

The #cephalic #furrow story from @yuchiunwang.bsky.social perspective. The saga is even longer than what’s in my thread. Worth reading 👇

Like "this is just the cephalic furrow. Why would you ask what it does?" Turns out, one needed an evolutionary approach. Congrats @bruvellu.bsky.social @paveltomancak.bsky.social @yuchiunwang.bsky.social et al and @endofthepier.bsky.social for shepherding this to publication!

The papers have been improved by reviewers @amartinezarias.bsky.social, @thibautbrunet.bsky.social & Cassandra Extavour. Thibaut synthesized the work beautifully in the #News_and_Views. None of that can happen without The Editor: @endofthepier.bsky.social (11/12) www.nature.com/articles/d41...

We had #four interdisciplinary teams, integrating dev-bio, evolution, tissue mechanics, and biophysical modeling, all going full throttle to understand the #CF. Still, it took more than 7 years to publish two papers back-to-back (10/12) www.nature.com/articles/s41... www.nature.com/articles/s41...

The important event for the genesis of the project was the mechanobiology conference @embl.org in 2022. My talk inspired Steffen Lemke to revisit the data on the distribution of #CF across the Dipteran phylogeny, revealing that it is an #evolutionary_novelty. Crucial insight! (8/12)

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

We started working together, and that meant that the powerful biophysical expertise of @yuchiunwang.bsky.social, Steffen's long-time collaborator under @hfspo.bsky.social, expanded the team. Bipasha Dey made some of the most complex experiments bridging dev-bio & tissue mechanics (9/12)

Tissue 'tectonic' collision is detrimental, but flies found two distinct solutions! Gratifying and grateful to be included in this collective effort, w/ Steffen Lemke, to crack the (or 'a') code of #cephalicfurrow, now out in @nature.com, all with @paveltomancak.bsky.social at the helm. (1/9)

Congratulations, Michael Dorrity and Anna Erzberger! The two EMBL Heidelberg group leaders have received ERC Starting Grants that will enable ambitious projects related to developmental timing and tissue self-organisation, respectively. Learn more: www.embl.org/news/awards-...

Dresden researchers @paveltomancak.bsky.social @bruvellu.bsky.social, Carl Modes, @cuencam15.bsky.social ‬ & colleagues published in @nature.com that a tissue fold in fruit fly embryos buffers mechanical stresses & may have evolved in response to mechanical forces. www.mpi-cbg.de/news-outreac...

Neue Studie von #UniHohenheim in #Nature: Fliegenembryonen nutzen raffinierte Strategien, um gefährliche Gewebespannungen auszugleichen. Mechanische Kräfte könnten damit ein Treiber der #Evolution sein. @springernature.com Mehr dazu: t1p.de/7qth2

Thrilled to share 🎉 I’m starting my lab at University of Zurich, DMLS as Assistant Professor (tenure track) from Jan 2026! The Neural MorphoGenomics & Developmental Dynamics Lab will be exploring how genes + morphogenesis shape brain development with organoids, imaging & spatial genomics 🧠🔬🧬

Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!

If you love cytoskeleton and tissue morphogenesis, have a read!

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...

Heartfelt obituary of Ben Shilo by Stas Shvartsman

FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz 💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚

We are searching for an enthusiastic scientist to join our team and establish annual killifish as a model system for early developmental biology and biophysics! @embl.org @embldbunit.bsky.social Apply here: embl.wd103.myworkdayjobs.com/EMBL/job/Hei... Please re-post 🙏

Thank you @the-node.bsky.social‬ for inviting me to write a 'Behind the Story' piece on our recent study! Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...

Lab Meeting with the Phng Lab Meet the lab of @phnglab.bsky.social, based @riken-bdr.bsky.social, Kobe, Japan. The lab is interested in vascular #morphogenesis, in particular, endothelial cell mechanobiology in #zebrafish 🐟 Find out more about the lab and what it's like working at RIKEN BDR: