New from our lab @crick.ac.uk. Nascent proteins emerge from the human ribosome into a cytosol packed with hundreds of different molecular chaperones. Which chaperones recognise specific nascent chains, and what dictates their binding preferences? www.biorxiv.org/content/10.6...

🚨 New paper from our lab just published in Nature🚨 www.nature.com/articles/s41... Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone ✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Are you a clinician looking for a fully-funded postdoctoral research opportunity? Check out our postdoctoral career development fellowships for clinicians, and see how you can join our vibrant community: www.crick.ac.uk/careers-and-...

Join us!

We are #Hiring! Our lab is looking for a LabTech/Lab Manager! Take a look to our research here! physics-of-life.tu-dresden.de/team/pol-gro... Drop a line if you are interested to know more details! #labtech #labtechnician #biology #labtechnicians #labmanager #labwork #Xenopus #zebrafish #devbiol

Abstract deadline looming! Coming join us in June for a great meeting on developmental origins of paediatric cancers, including neuroblastoma organised by @tsakiridis.bsky.social and friends @childrenwithcancer.bsky.social #neuralcrest www.crick.ac.uk/whats-on/dev...

Join us at SMBE26! We are in a golden period for understanding the evolution of gene regulation.

Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin. Great collaboration with the Schuijers lab! 👉 nature.com/articles/s41...

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...

SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉 www.biorxiv.org/content/10.6...

So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this! And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social! www.cell.com/developmenta...

If you are interested in an interdisciplinary project connecting tissue mechanics, synthetic approaches and dev bio, this is the position for you! we are excited to get this colaboration started!!👇👇🤩🤓👇👇

Our next #ForceTalk is Prof Yanlan Mao @yanlanmao.bsky.social on "Coping with mechanical stress: tissue dynamics during development, homeostasis and repair" 🗓️ 26 Nov 2025 🕒 15:00 - 16:00 GMT Online & open to all 👉 www.kcl.ac.uk/events/force-talk-yanlan-mao #mechanobiology @kingsnmes.bsky.social

Very happy to share the beautiful cover of @cp-trendscancer.bsky.social that is designed based on our review article on #platelets and their role, usage and targeting in #cancer and its #therapy Link to the full issue : www.cell.com/issue/S2405-... @inserm.fr @unistra.fr

I am happy to announce that my group has an opening for a funded PhD position to explore the intersection between mechanobiology and inflammation in the intestine. Please see the attached advertisement below. Thanks for circulating and forwarding! www.srcsb.uni-stuttgart.de/news/New-ope...

🚨 Check out our new paper is now online in its final version!!! 🎉 👏 Congratulations @alejotorrescano.bsky.social who led the study + past & current team @labspagnoli.bsky.social + collaborators #VigilanteLab @kingslsm.bsky.social ➡️ doi.org/10.1126/scia... short 🧵 below & more acknowledgments ⤵️

Researchers at the Crick have discovered that mice lacking a specific gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans. www.crick.ac.uk/news/2025-11...

This research was led by @luiz90vasc.bsky.social and Shaina Chor Mei Huang with corresponding author @drmichaelway.bsky.social

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! events.ibecbarcelona.eu/embl-ibec-co...

Tomorrow at @ISTAresearch.bsky.social in Vienna at 4:30 PM I will show and discuss how shapes can emerge (and disappear) from mixture of microtubules and molecular motors. #morphogenesis

🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel tinyurl.com/stnczkc6

The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...

We are offering a super exciting project to develop new ways of targeting metastatic cancer cells! Amazing supervisory team: Primary supervisor: Professor Joanna Loizou Associate supervisor: Professor Zoran Rankovic Secondary supervisor: Professor Victoria Sanz-Moreno @icr.ac.uk

Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social www.colcc.ac.uk/2026-phd-pro... crukradnet.colcc.ac.uk/phd-students...

Don’t miss the exciting ISSCR Webinar: Integrating Biophysics into Stem Cell Biology next Tuesday October 14! The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2 www.isscr.org/upcoming-pro...

The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...

Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025! Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025! Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

Congrats to everyone including JCS @jcellsci.bsky.social Editor Megan King @luskinglab.bsky.social & Editorial Advisory Board members Dennis Discher, Miho Iijima, James Olzmann @olzmannlab.bsky.social, Kristen Verhey @kjverhey1.bsky.social‬ for becoming ASCB fellows ‬ www.ascb.org/society-news...

🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….

1/N What are the organizational principles underlying crossmodal cortical connections? We address this in this new preprint, led by @alexegeaweiss.bsky.social & ‪@bturner-bridger.bsky.social‬ in collab w/ ‪@petrznam.bsky.social‬ @crick.ac.uk www.biorxiv.org/content/10.1...

Paper accepted 🥳 Many congratulations @tobyandrews.bsky.social So proud of what you have achieved! Can’t wait to see what you do next... Onwards and upwards from here!

Data drop! We just released an updated list of anti-ECM antibodies curated from the #HumanBioMolecularAtlasProgram Organ Mapping Antibody Panels #OMAP and the 9th release of the Human Reference Atlas #HRA. Check it out: sites.google.com/uic.edu/matr...

Check out our latest preprint, which is the latest production from our long-lasting collaboration with Andrey Klymchenko > functionnalizing NPs with humanized antibodies (i.e. Trastuzumab). Work performed by @vmittelheisser.bsky.social & O.Lefebvre in my lab. www.biorxiv.org/content/10.1...

⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference! 🧪Share your exciting discoveries with us!! 📍Malta 🗓️Talk Deadline: July 10 🔗http://bit.ly/49sCfJp @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social

Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling

🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu www.biorxiv.org/content/10.1...

Happy to be the next (and 1st female) @crg.eu director. The CRG always stood out to me, for its excellence in understanding life's principles, with implications for health and biodiversity, & its collaborative, open and innovative way of doing science. Thrilled to join its amazing community in 2026!

🧵Just out ! We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration. Here’s the story👇 authors.elsevier.com/c/1lM285Sx5g... Work done in @frelab.bsky.social at ‪ ‪ @institutcurie.bsky.social

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells. pubmed.ncbi.nlm.nih.gov/40419795/

We did it! 🎉 🍾🥂 Our Excellence Cluster Physics of Life (PoL) got renewed until 2032! I am so proud of our team and all the great work we did to achieve this.

Our work on lineage tracing with somatic epimutations is finally out in @nature.com! Check out the thread by @larsplus.bsky.social below. EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere. Detailed protocols coming out soon!

Impressive work by @santoslab.bsky.social creating a 3D model of human amnion from hESCs! www.cell.com/cell/fulltex...

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵