1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! events.ibecbarcelona.eu/embl-ibec-co...

Tomorrow at @ISTAresearch.bsky.social in Vienna at 4:30 PM I will show and discuss how shapes can emerge (and disappear) from mixture of microtubules and molecular motors. #morphogenesis

🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel tinyurl.com/stnczkc6

The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...

We are offering a super exciting project to develop new ways of targeting metastatic cancer cells! Amazing supervisory team: Primary supervisor: Professor Joanna Loizou Associate supervisor: Professor Zoran Rankovic Secondary supervisor: Professor Victoria Sanz-Moreno @icr.ac.uk

Looking for a PhD for 2026? We have 2 projects in collaboration with Clare Bennett (UCL) looking at macrophage metabolism in breast cancer. Check them out! @cruk-cityoflondon.bsky.social www.colcc.ac.uk/2026-phd-pro... crukradnet.colcc.ac.uk/phd-students...

Don’t miss the exciting ISSCR Webinar: Integrating Biophysics into Stem Cell Biology next Tuesday October 14! The webinar features paired tandem talks that brings together experimentalists and theorists working at the interface of stem cell biology and biophysics. 1/2 www.isscr.org/upcoming-pro...

The Francis Crick Institute PhD programme recruitment is now live and our lab is recruiting. If you are interested in studying the role of the extracellular matrix in tissue dynamics during development and cancer please apply – link below. Please share. www.crick.ac.uk/careers-stud...

Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025! Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

Don’t miss the exciting ISSCR Digital Webinar: Integrating Biophysics into Stem Cell Biology on October 14,2025! Together with Windie Höfs we have organized this webinar that features paired tandem talks of experimentalists and theorists working at the interface of stem cell biology and biophysics!

Congrats to everyone including JCS @jcellsci.bsky.social Editor Megan King @luskinglab.bsky.social & Editorial Advisory Board members Dennis Discher, Miho Iijima, James Olzmann @olzmannlab.bsky.social, Kristen Verhey @kjverhey1.bsky.social‬ for becoming ASCB fellows ‬ www.ascb.org/society-news...

🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….

1/N What are the organizational principles underlying crossmodal cortical connections? We address this in this new preprint, led by @alexegeaweiss.bsky.social & ‪@bturner-bridger.bsky.social‬ in collab w/ ‪@petrznam.bsky.social‬ @crick.ac.uk www.biorxiv.org/content/10.1...

Paper accepted 🥳 Many congratulations @tobyandrews.bsky.social So proud of what you have achieved! Can’t wait to see what you do next... Onwards and upwards from here!

Data drop! We just released an updated list of anti-ECM antibodies curated from the #HumanBioMolecularAtlasProgram Organ Mapping Antibody Panels #OMAP and the 9th release of the Human Reference Atlas #HRA. Check it out: sites.google.com/uic.edu/matr...

Check out our latest preprint, which is the latest production from our long-lasting collaboration with Andrey Klymchenko > functionnalizing NPs with humanized antibodies (i.e. Trastuzumab). Work performed by @vmittelheisser.bsky.social & O.Lefebvre in my lab. www.biorxiv.org/content/10.1...

⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference! 🧪Share your exciting discoveries with us!! 📍Malta 🗓️Talk Deadline: July 10 🔗http://bit.ly/49sCfJp @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social

Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling

🚨 Second preprint of the week! We uncover the multiscale dynamics of active viscoelastic buckling in epithelia. We harness these mechanical instabilities for synthetic morphogenesis. Led by @onenimesa.bsky.social 🙌. Theory by Marino Arroyo etal. @ibecbarcelona.eu www.biorxiv.org/content/10.1...

Happy to be the next (and 1st female) @crg.eu director. The CRG always stood out to me, for its excellence in understanding life's principles, with implications for health and biodiversity, & its collaborative, open and innovative way of doing science. Thrilled to join its amazing community in 2026!

🧵Just out ! We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration. Here’s the story👇 authors.elsevier.com/c/1lM285Sx5g... Work done in @frelab.bsky.social at ‪ ‪ @institutcurie.bsky.social

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells. pubmed.ncbi.nlm.nih.gov/40419795/

We did it! 🎉 🍾🥂 Our Excellence Cluster Physics of Life (PoL) got renewed until 2032! I am so proud of our team and all the great work we did to achieve this.

Our work on lineage tracing with somatic epimutations is finally out in @nature.com! Check out the thread by @larsplus.bsky.social below. EPI-clone is a revolutionary technique for lineage tracing and it will immediately impact how we trace clones everywhere. Detailed protocols coming out soon!

Impressive work by @santoslab.bsky.social creating a 3D model of human amnion from hESCs! www.cell.com/cell/fulltex...

We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵

Thanks to @cancerresearchuk.org for featuring our work on stem cell plasticity in CRC: news.cancerresearchuk.org/2025/05/09/s...

Thanks to @tanentzapflab.bsky.social & @sarawickstrom.bsky.social, chairs of an excellent Fibronectin, Integrins & Related Molecules GRC & to @martina-lerche.bsky.social & @mchastney.bsky.social for chairing the GRS. We look forward to Kairbaan Hodivala-Dilke & Tom Barker's 2027 meeting!

'Centrosomes and cancer: balancing tumor-promoting and inhibitory roles' - It was so much fun writing this review with Renata Basto! Thanks for bringing me on board 🙏 Perfect timing to reflect on the field's most recent advances and open questions 👇 www.cell.com/trends/cell-...

A very useful review for everyone who wants to learn more about the importance of ECM viscoelasticity in mechanotransduction and (patho)physiology.

Thrilled to share our new review article! “The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44... #ECM #Mechanobiology #DevelopmentalBiology

In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro. journals.biologists.com/jcs/article/...

Peer review completed within 7 days! Paying peer reviewers! Yes, it's possible. Fast & Fair peer review by @biologyopen.bsky.social More innovation from @biologists.bsky.social Details here: www.biorxiv.org/content/10.1...

Nature research paper: Overlapping nuclear import and export paths unveiled by two-colour MINFLUX https://go.nature.com/4iRwmJm

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩. It is free, w/o registration, and it will be exciting.m! Follows from my series of lectures at CdF last fall.

I’m excited to share our latest research from the Musser Lab, published today in Nature. Using two-color 3D MINFLUX, we directly visualized nuclear import and export events through transport-active nuclear pores. (1/5) www.nature.com/articles/s41...

Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

Please spread widely 🙏, thank you ! Dear community, we are actively looking for the mouse 344SQ lung adenocarcinoma cell line (129sv background) ? We would also be interested in any other mouse tumor cell line in this background (129sv). Highly appreciated ! Thank you in advance

Unique opportunity to join the CytoMorpho Lab (in Paris ❤️) as a postdoc to work on the self-organization and polarization of reconstituted networks made of microtubules, motors and actin filaments in vitro. Experience required. Please Repost 🙏 thanks !

Really excited to present the results of a great collaboration between our group @poldresden.bsky.social and Elliot Hawkes at @ucsantabarbara.bsky.social, which were just published in @science.org. A mix of physics, biology and robotics! 🤖 😀 ▶️ www.science.org/doi/10.1126/...

Exciting work on ECM mechanosensing in cancer invasion! Congrats to Oscar, Vicky and all the authors. Thanks for having us on board!