🚨Excited to share our new paper where we find that in situ ECM stiffening of mature mammary acini induces BM loss, FN deposition & invasion through α3β1/α5β1–FAK→Piezo1 axis—linking integrin switching to MSCs and epithelial remodelling. Led by the amazing Kabilan Sakthivel tinyurl.com/stnczkc6

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Just learned that Frank Stahl (of the Meselson and Stahl DNA replication experiment ("the most beautiful experiment in biology") died at the beginning of April, to no fanfare. Here's a lovely video of them reminiscing: www.youtube.com/watch?v=7-tn...

The feeling when you get back to the lab after a week at a gordon conference - totally inspired and energised after hearing incredible science and meeting amazing people. Thank you @tanentzapflab.bsky.social and @sarawickstrom.bsky.social for GRC Fibronectin, Integrins and related molecules.

Fantastic surprise to have Reinhard Fässler visit Lund to talk about kindlins, integrins and mitosis.

Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺. Apply now👇 tinyurl.com/4mby45hf

Seems like a good time to share and appreciate this incredible window to future cancer treatments and the opportunities ahead (and also appreciate its journey from test tubes to bacteria to cell culture to animal models to covid vaccine and now to this-) www.nature.com/articles/s41...

So many heartbreaking stories right now coming from the US. Joe was a post-doc fellow here at WCMM Lund University and moved back to Fort Collins for family and career. www.cbsnews.com/colorado/new...

Dear federal scientists: If you have been affected by the probationary firings and would be willing to speak with Science, please reach out to me by email ([email protected]) or on Signal. We can guarantee annonymity.

Big first for our lab on Friday as Wesley became its first PhD graduate. Congrats Wesley and a big thanks to an amazing committee including @bengoult.bsky.social (opponent), @sciezgin.bsky.social , Gunilla Westergren-Thorsson, Catharina Hagerling and Daniel Engelbertsen.

🚨🚨🚨Come and join us at the Wallenberg Center for Molecular Medicine- tenure track positions in broad areas of 1)basic research and 2)advanced therapy in regenerative medicine. 🚨Deadline Feb 10th. DM me if you have any questions lu.varbi.com/en/what:job/... lu.varbi.com/en/what:job/...

Amazing and beautiful work as usual from @alushinlab.bsky.social

I am very excited to (delayed) share our preprint which has been led by Kabilan Sakthivel on mechanisms by which ECM stiffening of normal 3D tissues in their native environment drives invasive phenotypes www.biorxiv.org/content/10.1...

For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...

Are you working on #ECM or mechanobiology in the mammary gland or in breast cancer? Together with Jason Northey we are guest editing a collection on the topic for the Journal of Mammary gland biology and Neoplasia. Submission of articles is now open! link.springer.com/collections/...

This is a scientific life changing experience-

Hey PIs, do your trainees need to learn light microscopy and image analysis? Send them to us! Financial aid is available. meetings.cshl.edu/coursesinten...

Crazy!- A rare case of malignant tumor transplantation from patient to surgeon: www.nejm.org/doi/full/10....

Sakthivel K, et al. {beta}1 Integrin-FAK-Piezo1 signalling axis drives in-situ stiffening mediated ECM remodelling and invasion of 3D breast epithelium. bioRxiv posted 8 January 2025 doi:10.1101/2025.01.07.631639. www.biorxiv.org/content/10.1...

In all seriousness,use CiteAb and Antibodypedia, look for KO/KD validated antibodies, best - recombinant, second best - monoclonal, and if possible do your own KO/KD controls, or induction by ligand/small molecule,if not - compare hyperexpressing with low expressing cells (from depmap/protein atlas)

Pre-announcing the 10th Biennial European CellMech conference organized in Leuven 🇧🇪 from September 30th to October 3rd, 2025. cellmech2025.org Save the date !

We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at: @dev-journal.bsky.social @jcellsci.bsky.social @jexpbiol.bsky.social @dmmjournal.bsky.social @biologyopen.bsky.social @the-node.bsky.social @prelights.bsky.social @focalplane.bsky.social

The GRC scam emails are getting quite good, huh?

Seems like a good time to post this: Our centre is recruiting a tenure-track PI with focus on basic research into regenerative medicine and disease mechanisms. Excellent start-up package, colleagues & infrastructure in a fantastic college town.Other useful links below lu.varbi.com/en/what:job/...

I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added go.bsky.app/5Gzo7oZ