Marintia Nava-García
@marintianava.bsky.social
📤 456
📥 663
📝 9
Passionate about cell biology. PhD @ViennaBiocenter. Currently doing a postdoc at IGBMC.
reposted by
Marintia Nava-García
James Olzmann
5 days ago
Sooo happy to share our new paper in
@nature.com
“CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with
@arrudalab.bsky.social
, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...
loading . . .
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature
CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...
https://www.nature.com/articles/s41586-025-10064-4
6
81
37
reposted by
Marintia Nava-García
Sarah Cohen
14 days ago
Cells come in many shapes and sizes, with diverse physiological functions. But how do
#organelles
and their interaction networks remodel during
#differentiation
of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13
add a skeleton here at some point
4
81
38
reposted by
Marintia Nava-García
Jeremy Baskin
about 2 months ago
Thrilled to share our latest study, led by
@reikatei.bsky.social
, in
@natchembio.nature.com
! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
loading . . .
Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology
Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.
https://www.nature.com/articles/s41589-025-02104-x
7
156
68
reposted by
Marintia Nava-García
André Nadler
about 2 months ago
I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days.
www.nature.com/articles/s41...
loading . . .
Systematic analyses of lipid mobilization by human lipid transfer proteins - Nature
Nature - Systematic analyses of lipid mobilization by human lipid transfer proteins
https://www.nature.com/articles/s41586-025-10040-y
0
25
11
reposted by
Marintia Nava-García
bioRxiv Cell Biology
3 months ago
Tom70-mediated mitochondria-nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis
https://www.biorxiv.org/content/10.1101/2025.11.20.689567v1
0
6
2
reposted by
Marintia Nava-García
Gautam Dey
2 months ago
Thanks
@jcellsci.bsky.social
for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/
@alebenoit.bsky.social
@eelcotromer.bsky.social
@fritzlaylin.bsky.social
journals.biologists.com/jcs/article/...
loading . . .
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
https://journals.biologists.com/jcs/article/138/24/jcs264348/370175/Evolutionary-cell-biology-comes-of-age
0
83
38
reposted by
Marintia Nava-García
André Nadler
3 months ago
This opening statement made me actually open and read the paper. You all should, too. It's a wonderful piece of work. Thought-provoking in the best sense. It may very well be that Yamuna & team have found a proxy measurement for local metabolic activity. Which would be a game changer.
add a skeleton here at some point
2
32
10
reposted by
Marintia Nava-García
Alice Ting
3 months ago
New work describes our efforts to achieve CRISPR editing of the mitochondrial genome.
www.biorxiv.org/lookup/conte...
loading . . .
Towards CRISPR-based editing of the mitochondrial genome in yeast
Mitochondria, which evolved from symbiotic bacteria, possess their own genomes (mtDNA) and support independent transcription and translation within the organelle. Given the essential role of mtDNA in ...
https://www.biorxiv.org/lookup/content/short/2025.12.09.693232v1
1
41
10
reposted by
Marintia Nava-García
Gal Haimovich ☣ 🧪🔬🎗
3 months ago
this is amazing they show some compelling evidence for 3' to 5' translation
#RNASky
#RNABiology
🧪
www.biorxiv.org/content/10.6...
loading . . .
3' to 5' Translation of Circular RNAs?
For decades, the 5' to 3' direction of translation has been a central dogma of molecular biology. Here we present evidence that eukaryotic circular RNAs (circRNAs) can serve as templates for 3' to 5' ...
https://www.biorxiv.org/content/10.64898/2025.12.08.692888v1
2
26
15
reposted by
Marintia Nava-García
Philipp Niethammer
3 months ago
Joe Shen’s and Zaza Gelashvili’s work on the role of the ER in nuclear membrane mechanotransduction finally came out in a journal!
loading . . .
Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction
Nature Cell Biology - Shen, Gelashvili and Niethammer developed an inner nuclear membrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer.
https://rdcu.be/eTQHX
2
19
5
reposted by
Marintia Nava-García
Buzz Baum
3 months ago
And another Asgard paper. Cells in motion! Wow!
www.biorxiv.org/content/10.1...
loading . . .
Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota)
Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion, and spatially organized signalling pathways. Asgard archaea (phylum Promethearchaeota...
https://www.biorxiv.org/content/10.1101/2025.11.30.690169v1?rss=1
1
40
14
reposted by
Marintia Nava-García
Marco Incarbone
3 months ago
Preprint alert! It is my great pleasure to announce the first manuscript from the lab, a story that started
@gmivienna.bsky.social
and was mainly accomplished by the intrepid
@gesahoffmann.bsky.social
at
@mpi-mp-potsdam.bsky.social
. A brief thread with our findings
www.biorxiv.org/content/10.1...
loading . . .
AGO5 restricts virus vertical transmission in plant gametophytes
The propagation of a viral infection from a host parent to its progeny is known as vertical transmission, or seed transmission in plants. It allows viral infections to rapidly spread locally via polle...
https://www.biorxiv.org/content/10.1101/2025.11.28.691182v1
2
77
39
reposted by
Marintia Nava-García
Javier Espadas
3 months ago
New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...
loading . . .
Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...
https://www.biorxiv.org/content/10.1101/2025.11.28.690958v1
1
81
41
reposted by
Marintia Nava-García
Abdou Rachid Thiam
3 months ago
And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport. Definitely worth a deep read:
www.pnas.org/doi/10.1073/...
add a skeleton here at some point
0
31
18
reposted by
Marintia Nava-García
Jana Helsen
3 months ago
How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉
doi.org/10.1038/s41586-025-09779-1
8
184
92
reposted by
Marintia Nava-García
Johana Rotterova
3 months ago
Is it a flagellate? A tiny ball with tentacles? Contamination in my ciliate culture? NEW SUPERGROUP OF EUKARYOTES? Yes to all 4! Meet Solarion - just out in
#Nature
doi.org/10.1038/s415...
Huge congrats to Marek Valt, Cepicka Lab & the star team! Very happy to be part of this project.
#ProtistsOnSky
5
119
47
reposted by
Marintia Nava-García
Carmelo Ferrai
4 months ago
Great work from the lab of
@jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
loading . . .
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts between individual motifs within cis-regulatory elements and reveal a unified model of biophysically mediated enhan...
https://www.cell.com/cell/fulltext/S0092-8674(25)01178-X
0
15
8
reposted by
Marintia Nava-García
Juanma García-Arcos
4 months ago
Launching
celldynamicslab.com
, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
loading . . .
Main - Cell Dynamics and Fragmentation Lab
The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...
https://celldynamicslab.com
14
73
36
reposted by
Marintia Nava-García
Gautam Dey
4 months ago
And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function. Beautiful tomography and microscopy - congrats all 🤩
add a skeleton here at some point
1
44
11
reposted by
Marintia Nava-García
Buzz Baum
4 months ago
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
8
162
53
reposted by
Marintia Nava-García
Tanmay Bharat
4 months ago
An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
10
387
192
reposted by
Marintia Nava-García
Pierre Bourguet
4 months ago
How is epigenetic information inherited? We found that CDCA7 proteins are critical players in the inheritance of DNA methylation at CG sites in plants, and this is true both in the lab and in the wild. How does this work? 🧵👇
add a skeleton here at some point
2
45
16
reposted by
Marintia Nava-García
Caterina Giannini
4 months ago
Curious about my main PhD work?!🔬🌱 Please have a look on
@biorxivpreprint.bsky.social
biorxiv.org/content/10.1101/2025.11.04.686542v1
Connecting auxin-autophagy-development
add a skeleton here at some point
2
21
7
reposted by
Marintia Nava-García
Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦
4 months ago
🚨Our collaboration with
@centriolelab.bsky.social
&
@gautamdey.bsky.social
is out today in
@cp-cell.bsky.social
We show that
#Expansion
#Microscopy
is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky
#SciComm
#SciSky
www.cell.com/cell/fulltex...
loading . . .
15
215
109
reposted by
Marintia Nava-García
Gioele La Manno
5 months ago
🧠 The Lipid
#Brain
Atlas is out now! If you think
#lipids
are boring and membranes are all the same, prepare to be surprised. Led by
@lucafusarbassini.bsky.social
with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
7
283
121
reposted by
Marintia Nava-García
André Nadler
5 months ago
Lipid imaging on the cover of
@nature.com
! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article:
www.nature.com/articles/s41...
9
166
43
reposted by
Marintia Nava-García
Eric Topol
5 months ago
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
loading . . .
Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits c...
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00388-2
7
146
45
reposted by
Marintia Nava-García
Thibaut Brunet
5 months ago
Latest from ours:
www.cell.com/cell-reports...
This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
10
244
111
Very happy and lucky to continue my scientific journey as a postdoc in the Sumara Lab! 🌞
add a skeleton here at some point
5 months ago
0
16
1
reposted by
Marintia Nava-García
Yale Cell Biology
5 months ago
Did you know that all nuclear pore complexes (NPCs) are not the same?
@luskinglab.bsky.social
propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction.
www.nature.com/articles/s41...
loading . . .
Nuclear mechanics as a determinant of nuclear pore complex plasticity - Nature Cell Biology
In this Review, Lusk et al. discuss emerging insights into nuclear pore complex variability with regard to composition and dilation state, and propose nuclear mechanics as a key determinant of driving...
https://www.nature.com/articles/s41556-025-01768-w
0
17
7
reposted by
Marintia Nava-García
Itay Budin
6 months ago
Very excited to share new work out today in
@natchembio.nature.com
on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n)
www.nature.com/articles/s41...
loading . . .
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
https://www.nature.com/articles/s41589-025-02021-z
7
163
76
reposted by
Marintia Nava-García
Wanlu Zhang
6 months ago
Excited to share the preprint from my postdoc work
@ellenberglab.bsky.social
! 🌟 During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗
doi.org/10.1101/2025...
loading . . .
Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis
Nuclear envelope (NE) reformation after mitosis is essential for daughter cell viability and requires tightly coordinated nuclear pore complex (NPC) assembly and nuclear membrane reformation. To revea...
https://doi.org/10.1101/2025.09.08.674396
0
12
3
reposted by
Marintia Nava-García
Nature Reviews Molecular Cell Biology
6 months ago
ICYMI: New Online! Structure, function and assembly of nuclear pore complexes
loading . . .
Structure, function and assembly of nuclear pore complexes
Nature Reviews Molecular Cell Biology, Published online: 09 September 2025; doi:10.1038/s41580-025-00881-wRecent near-atomic structures of the nuclear pore complex provide insights into its assembly and function — how it acts as a selective permeability barrier, regulates nucleocytoplasmic transport such as mRNA export, and integrates mechanical forces experienced by the cell and nucleus.
https://bit.ly/4nqUQv1
0
4
1
reposted by
Marintia Nava-García
Jorge Ferreira
6 months ago
New preprint from the lab! Please check it out. 🚨 Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
loading . . .
Chromosome condensation mechanically primes the nucleus for mitosis
Timely and accurate transition into mitosis is essential to preserve genome integrity and avoid chromosome segregation errors. This transition depends on spatial and temporal activity patterns of the ...
https://www.biorxiv.org/content/10.1101/2025.09.01.673438v1
3
37
13
reposted by
Marintia Nava-García
Nature
6 months ago
For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began
go.nature.com/3JyRV4S
loading . . .
How did life get multicellular? Five simple organisms could have the answer
Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.
https://go.nature.com/3JyRV4S
4
132
55
reposted by
Marintia Nava-García
Clausen Lab
6 months ago
big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology.
rdcu.be/eBGJv
loading . . .
Quantitative imaging of lipid transport in mammalian cells
Nature - Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.
https://rdcu.be/eBGJv
1
58
21
reposted by
Marintia Nava-García
André Nadler
6 months ago
Out today in
@nature.com
: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
31
345
153
reposted by
Marintia Nava-García
Journal of Cell Biology
7 months ago
Heffler and
@LammerdingLab.bsky.social
discuss recent studies from the
@schliekerlab.bsky.social
(
doi.org/10.1083/jcb....
) and
@hennelab.bsky.social
(
doi.org/10.1016/j.ce...
) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum.
rupress.org/jcb/article/...
0
25
11
reposted by
Marintia Nava-García
Milena Schuhmacher
7 months ago
We are hiring! If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland! More information on
www.epfl.ch/labs/gr-schu...
loading . . .
Open positions
GR-SCHUHMACHER
https://www.epfl.ch/labs/gr-schuhmacher/open-positions/
0
37
34
reposted by
Marintia Nava-García
Gautam Dey
7 months ago
Want to acquire
#ExM
images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With
@dudinlab.bsky.social
@embl.org
@biology-unige.bsky.social
@moorefound.bsky.social
loading . . .
1
105
57
reposted by
Marintia Nava-García
Christian Fankhauser
8 months ago
Remarkable paper explaining how sea slugs maintain chloroplasts obtained by kleptoplasty active for many month & eventually digest them for resources
www.cell.com/cell/fulltex...
loading . . .
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2900637-3
0
84
37
reposted by
Marintia Nava-García
Journal of Cell Biology
9 months ago
New study showing the development of pan-Expansion Microscopy by Morgan et al.
@luskinglab.bsky.social
to reveal the molecular composition and structural plasticity of individual nuclear pore complexes including LINC complex-dependent dilation.
rupress.org/jcb/article/...
loading . . .
0
30
11
reposted by
Marintia Nava-García
Gregor Mendel Institute of Molecular Plant Biology
9 months ago
Congratulations to Marintia Nava on the completion of her PhD! Marintia, a researcher in the Dagdas Lab, presented her dissertation titled “Characterization of a novel selective autophagy pathway for protein quality control in Arabidopsis thaliana” during her PhD defense.
0
13
2
reposted by
Marintia Nava-García
Matthias C. Rillig
10 months ago
Wow: check it out; these fungi distribute their chromosomes across different nuclei! Normally each nucleus has a complete set of all chromosomes. Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science
www.science.org/doi/10.1126/...
loading . . .
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered...
https://www.science.org/doi/10.1126/science.abn7811?utm_source=sfmc&utm_medium=email&utm_content=alert&utm_campaign=SCIeToc&et_rid=35361117&et_cid=5616351
0
55
28
reposted by
Marintia Nava-García
11 months ago
✍️Our collaborative project with the
@becklab.bsky.social
(
@mpibp.bsky.social
) and the Kräusslich lab who applied innovative ultrastructural analyses to analyze nuclear pores in Nup133-/- embryonic stem cells and neural progenitors is now out
@naturecomms.bsky.social
! 🔗
www.nature.com/articles/s41...
loading . . .
Nuclear pores safeguard the integrity of the nuclear envelope - Nature Cell Biology
Taniguchi et al. structurally analyse nuclear pore complex architecture in situ during differentiation, which is associated with mechanical constraints on the nuclear envelope. They link nuclear pore ...
https://www.nature.com/articles/s41556-025-01648-3
2
15
8
reposted by
Marintia Nava-García
Beck Laboratory
11 months ago
(1/3) Together with the labs of Valerie Doye
@vdoye.bsky.social
and Hans-Georg-Kräusslich, we analyzed NPC structure in Nup133 null mESCs. We found heterogenous NPCs featuring non-canonical symmetries and missing subunits. Now online
@naturecellbiology.bsky.social
.
www.nature.com/articles/s41...
1
72
24
reposted by
Marintia Nava-García
CIBSS – Centre for Integrative Biological Signalling Studies
12 months ago
It’s
#InternationalWomensDay
tomorrow! We took the occasion to talk to molecular biologist & CIBSS leadership team member
@kraftlabfr.bsky.social
about
#Equality
,
#CultureChange
and the power of mentoring and supportive networks in science. 📖 Read the full interview here:
kurzlinks.de/ndwd
0
16
10
reposted by
Marintia Nava-García
André Nadler
12 months ago
Are lipids actively sorted during clathrin mediated endocytosis like proteins?
@mathilda95.bsky.social
addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...
2
114
47
reposted by
Marintia Nava-García
Suayb Üstün
12 months ago
Wow! The Proteasome generates antimicrobial peptides that directly affect bacterial membranes
#proteostasis
www.nature.com/articles/s41...
loading . . .
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
https://www.nature.com/articles/s41586-025-08615-w
0
27
11
reposted by
Marintia Nava-García
Austin E. Y. T. Lefebvre
about 1 year ago
Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in
@naturemethods.bsky.social
! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
loading . . .
4
188
84
Load more
feeds!
log in