Happy to share that this beautiful work by @mudgal17.bsky.social in collaboration with the Weis lab @eth-dbiol.bsky.social, discovering a new membrane fusion mechanism in eukaryotes, is finally out in peer-reviewed form at @cp-molcell.bsky.social. www.cell.com/molecular-ce...

Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...

How did animal senses evolve? Max Coyle et al. used choanoflagellates to uncover TRPW, ancient ion channels predating animal somatosensory receptors. TRPW links microbial prey ecology to evolution of receptor structure, sensory organelles, & multicellular processing. www.biorxiv.org/content/10.6...

Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...

☄️New biosensor!☄️ We present Meteor, our GFP-based methionine optical reporter, which can be used to measure methionine dynamics across scales, from subcellular to organisms like C elegans! Plasmids will be deposited with Addgene. www.biorxiv.org/content/10.6...

Science really takes a village. Thrilled to share this with my friend @dudinlab.bsky.social, and with our brilliant and fearless teams, our collaborators around the world and our mentors - in my case a special shoutout to Buzz Baum, Jan Ellenberg and @monicabettencourt.bsky.social. 1/2

Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!

What membrane properties do cells maintain through regulation of lipid metabolism? In a new paper, we identify intrinsic curvature stress as one such parameter and show how different (eukaryotic) cell types employ different lipids to do that www.cell.com/cell-reports...

Excited to share the first study from the Morstein Lab on a new approach that enables selective editing, tagging, and visualization of mammalian lipids www.biorxiv.org/cgi/content/... #chembio #lipidtime @caltech.edu @caltechcce.bsky.social @harayamajrlab.bsky.social @logan-tenney.bsky.social

Beyond proteins and DNA, #lipids are emerging as key players in nuclear biology - shaping nuclear envelope dynamics, mechanosensing, gene regulation and genome stability. Our new Perspective highlights recent advances, open questions, and future directions 👉 journals.biologists.com/jcs/article/...

Why do nucleoli adopt irregular shapes despite their liquid-like nature? Sara Cuylen-Häring and colleagues find that Ki-67 mediates this irregularity by tethering chromatin at the surface and creating internal chromatin invaginations link.springer.com/article/10.1...

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density. Lipid-CLEM, now out in @natcellbio.nature.com brought to you by @mathilda95.bsky.social changes that: www.nature.com/articles/s41...

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations. www.nature.com/articles/s41...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance? www.nature.com/articles/s41... More info 👇

I've been waiting for this Titeca et al. story from Anne-Claude Gavin's lab to come out: A systematic, comprehensive analysis of lipid transfer protein cargo selection, a truly massive undertaking. What a time to work in lipid biology. Cool stuff every few days. www.nature.com/articles/s41...

Tom70-mediated mitochondria-nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis https://www.biorxiv.org/content/10.1101/2025.11.20.689567v1

Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...

This opening statement made me actually open and read the paper. You all should, too. It's a wonderful piece of work. Thought-provoking in the best sense. It may very well be that Yamuna & team have found a proxy measurement for local metabolic activity. Which would be a game changer.

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. www.biorxiv.org/lookup/conte...

this is amazing they show some compelling evidence for 3' to 5' translation #RNASky #RNABiology 🧪 www.biorxiv.org/content/10.6...

Joe Shen’s and Zaza Gelashvili’s work on the role of the ER in nuclear membrane mechanotransduction finally came out in a journal!

And another Asgard paper. Cells in motion! Wow! www.biorxiv.org/content/10.1...

Preprint alert! It is my great pleasure to announce the first manuscript from the lab, a story that started @gmivienna.bsky.social and was mainly accomplished by the intrepid @gesahoffmann.bsky.social at @mpi-mp-potsdam.bsky.social. A brief thread with our findings www.biorxiv.org/content/10.1...

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

And the saga continues! Our collaborative work with outstanding Justin Korfhage & Thomas Melia’s lab in PNAS shows that ATG2A transfers triglycerides and does so bidirectionally! An exciting twist in our understanding of lipid transport. Definitely worth a deep read: www.pnas.org/doi/10.1073/...

How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1

Is it a flagellate? A tiny ball with tentacles? Contamination in my ciliate culture? NEW SUPERGROUP OF EUKARYOTES? Yes to all 4! Meet Solarion - just out in #Nature doi.org/10.1038/s415... Huge congrats to Marek Valt, Cepicka Lab & the star team! Very happy to be part of this project. #ProtistsOnSky

Great work from the lab of @jojdavies.bsky.social Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions www.cell.com/cell/fulltex...

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

And just when you thought things were settling down, the enigmatic Asgard archaea have another surprise in store! Cell cycle/life cycle stage-specific internal compartments with almost no eukaryote-derived clues as to how they might function. Beautiful tomography and microscopy - congrats all 🤩

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

How is epigenetic information inherited? We found that CDCA7 proteins are critical players in the inheritance of DNA methylation at CG sites in plants, and this is true both in the lab and in the wild. How does this work? 🧵👇

Curious about my main PhD work?!🔬🌱 Please have a look on @biorxivpreprint.bsky.social biorxiv.org/content/10.1101/2025.11.04.686542v1 Connecting auxin-autophagy-development

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice) www.cell.com/cell-metabol...

Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

Very happy and lucky to continue my scientific journey as a postdoc in the Sumara Lab! 🌞

Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction. www.nature.com/articles/s41...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Excited to share the preprint from my postdoc work @ellenberglab.bsky.social! 🌟 During mitotic exit, cells rebuild thousands of nuclear pores within minutes. How do tiny holes expand to selective channels, and how is this coordinated with the nuclear envelope remodeling? 🔗 doi.org/10.1101/2025...

ICYMI: New Online! Structure, function and assembly of nuclear pore complexes

New preprint from the lab! Please check it out. 🚨 Have you ever wondered how cells decide when it’s time to divide? So did we! www.biorxiv.org/content/10.1...

For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began go.nature.com/3JyRV4S

big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...