Toni Gabaldón
@tonigabaldon.bsky.social
📤 787
📥 313
📝 131
pinned post!
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
17 days ago
10
263
135
reposted by
Toni Gabaldón
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
17 days ago
10
263
135
reposted by
Toni Gabaldón
BIST-Barcelona Institute of Science and Technology
11 days ago
🦠 How did our cells originate? A study by
@gabaldonlab.bsky.social
at
@irbbarcelona.org
&
@bsc-cns.bsky.social
suggests cellular complexity emerged gradually over millions of years, rather than from a single evolutionary event. 📝 Published in
@nature.com
#BISTCommunity
👉
bist.eu/a-study-by-i...
0
9
6
Monday 15th of June at 12:30 I will be giving a talk at the Faculty of Sciences of
#Tetouan
(Morocco). I will be talking about our recent work on the emergence of drug resistance and new pathogenic species from environmental sources in
#Candida
related yeasts.
13 days ago
0
4
1
Very proud of Islam, who performed part of her thesis with us at
@irbbarcelona.org
. Has been a pleasure to attend the defence, and has been my first chance to visit Morocco.
add a skeleton here at some point
14 days ago
0
3
1
reposted by
Toni Gabaldón
Comparative genomics group IRB-BSC Barcelona (PI: Toni Gabaldón)
14 days ago
Congratulations to our new Doctor, Islam Ahaik who obtained her PhD today at the Faculty o Sciences in Tetouan.
0
3
2
reposted by
Toni Gabaldón
Mathieu M.J.E. Rebeaud
15 days ago
Gene ancestries reveal diverse microbial associations during eukaryogenesis Fantastic paper from
@microbiobits.bsky.social
@tonigabaldon.bsky.social
and colleagues.
www.nature.com/articles/s41...
loading . . .
Gene ancestries reveal diverse microbial associations during eukaryogenesis - Nature
Phylogenomic reconstruction of the proteome of the last eukaryotic common ancestor sheds light on the origin of eukaryotes, indicating an important role of horizontal transfer of genes from diverse ba...
https://www.nature.com/articles/s41586-026-10639-9
0
5
3
reposted by
Toni Gabaldón
Ricard Solé
14 days ago
This theoretical approach (previously in this
@pnas.org
s.org
paper by
@nigelgoldenfeld.bsky.social
and Carl Woese
www.pnas.org/doi/abs/10.1...
) seems consistent with the recent work by
@tonigabaldon.bsky.social
on the complex paths towards the emergence of LUCA.
0
18
4
reposted by
Toni Gabaldón
ICREA Community
14 days ago
I si l'origen de les nostres cèl·lules no és com ens pensàvem? 🦠🤔 Un estudi liderat pel
#RecercaireICREA
@tonigabaldon.bsky.social
(
@irbbarcelona.org
@bsc-cns.bsky.social
) ha descrit el rol de bacteris i virus gegants en l’origen de les cèl·lules complexes. 👇🏼
www.lavanguardia.com/ciencia/2026...
loading . . .
Descubren cómo se formó la célula de la que descienden todos los animales y plantas
Científicos de Barcelona revelan un episodio clave de la evolución de la vida en la Tierra ocurrido hace 2.000 millones de años
https://www.lavanguardia.com/ciencia/20260610/11561050/descubren-como-formo-celula-descienden-todos-animales-plantas.html
0
8
5
reposted by
Toni Gabaldón
Ricard Solé
15 days ago
How did complex cells emerge? In this groundbreaking paper,
@tonigabaldon.bsky.social
& co show that eukaryotes arose through multiple waves of ancient genetic exchange involving diverse bacteria (& giant viruses!) revealing a far more complex origin than we imagined.
www.nature.com/articles/s41...
5
152
62
reposted by
Toni Gabaldón
Ismael Mingarro
16 days ago
Y si la aparición d las células eucariotas no hubiera sido tan sencilla como pensábamos? Gran trabajo
@tonigabaldon.bsky.social
🙌🏻🙌🏻🙌🏻🥂🍾
www.expansion.com/directivos/e...
loading . . .
Científicos españoles describen un intrincado puzzle genético microbiano que originó la vida celular compleja
El origen y el proceso por el que surgieron las células eucariotas es aún una de las grandes preguntas de la biología desde que Lynn Margulis* propusiera que la mitocondria...
https://www.expansion.com/directivos/estilo-vida/salud/2026/06/10/6a2909c6e5fdea0b688b4593.html
0
6
3
reposted by
Toni Gabaldón
Alex de Mendoza
16 days ago
Funny to get quoted on a pun about the origin of eukaryotes being a bit of a promiscuous relationship in the 🇪🇸 press, but glad to help communicate
@tonigabaldon.bsky.social
& his team's fatnastic work, which highlights the importance of giant viruses 👾 in eukaryotic origins
@nature.com
. Congrats!
add a skeleton here at some point
2
12
3
www.elconfidencial.com/tecnologia/c...
loading . . .
Un 'ménage à trois' celular: un equipo español revoluciona lo que sabíamos del origen de la vida
El gran salto evolutivo por el que surgieron las células complejas que nos conforman sigue siendo un enigma. Una nueva investigación con el supercomputador de Barcelona revela que hay más actores implicados de los que pensábamos
https://www.elconfidencial.com/tecnologia/ciencia/2026-06-10/origen-de-la-vida-celulas-investigacion-espanola-nature_4370387/
16 days ago
0
3
2
reposted by
Toni Gabaldón
Science Media Centre España
17 days ago
🦠Un estudio español en @Nature replantea el origen de nuestras células como una historia de alianzas microbianas 🗨️Alex de Mendoza: "El proceso de formación de los eucariotas no fue una relación monógama de dos organismos, sino más tipo ménage à trois"
sciencemediacentre.es/un-estudio-e...
0
7
4
www.ara.cat/ciencia-medi...
loading . . .
Què som i d'on venim? Un estudi català reescriu la història de la vida complexa
Investigadors de l'IRB i el BSC reconstrueixen l'origen dels eucariotes i apunten que són fruit de donacions genètiques microbianes de milions d'anys
https://www.ara.cat/ciencia-medi-ambient/d-venim-estudi-catala-reescriu-historia-vida-complexa_1_5764281.html
16 days ago
0
4
1
reposted by
Toni Gabaldón
STCmicrobeblog
16 days ago
"Thus, the prokaryotic-to-eukaryotic transition was probably a gradual and complex process, with a constant flow of HGT from diverse sources."
#SymbioSky
add a skeleton here at some point
0
9
2
reposted by
Toni Gabaldón
Science Media Centre España
24 days ago
🦠Los restos de Ötzi, el ‘hombre de hielo’, albergan microorganismos modernos y antiguos 🗨️ Toni Gabaldón: "Los microbios, incluidas las levaduras, se abren camino en ambientes tan extremos como las temperaturas por debajo de 0"
sciencemediacentre.es/los-restos-d...
0
5
1
reposted by
Toni Gabaldón
Lzvolk
17 days ago
Fantastic paper. Esp challenging the typical binary process of genesis or transition. Just as the first cells as we know them were possibly survivors of multitudes of attempts that did not survive to evolve. The origin of cellular life was not simple; neither was evolution to multiple cell types.
add a skeleton here at some point
1
6
3
reposted by
Toni Gabaldón
Anna Papageorgiou
17 days ago
The origin of complex cells may have been far messier than we thought!
add a skeleton here at some point
0
4
2
reposted by
Toni Gabaldón
Patricia Ruiz Guevara
17 days ago
"Entender el origen de la vida nos ayuda a explicar el mundo en que vivimos, incluida nuestra propia existencia", dice
@tonigabaldon.bsky.social
, autor principal del estudio. También impulsa otras investigaciones y abre la puerta a "posibilidades que no imaginamos". Los superordenadores ayudan 💻 🦠👇🏼
loading . . .
Un 'ménage à trois' celular: un equipo español revoluciona lo que sabíamos del origen de la vida
El gran salto evolutivo por el que surgieron las células complejas que nos conforman sigue siendo un enigma. Una nueva investigación con el supercomputador de Barcelona revela que hay más actores implicados de los que pensábamos
https://www.elconfidencial.com/tecnologia/ciencia/2026-06-10/origen-de-la-vida-celulas-investigacion-espanola-nature_4370387/
0
6
3
reposted by
Toni Gabaldón
Alfonso Valencia
17 days ago
Una investigación fundamental sobre el origen y evolución de la vida. La investigación básica - apoyada en la supercomputacion- entra en temas que parecería imposibles abordar hace unos años. Bravo por Toni y su grupo!!
1
4
1
reposted by
Toni Gabaldón
Cristina Muñoz Pinedo
17 days ago
No wonder it’s complicated to understand immune responses. We are part bacteria part virus too, more than we thought! Congrats superToni and Gabaldón lab
add a skeleton here at some point
0
9
1
reposted by
Toni Gabaldón
Iñaki Ruiz-Trillo
17 days ago
1/7 We often picture eukaryogenesis as a symbiosis between two lineages: an archaeal host & the ancestor of mitochondria. But what if the origin of eukaryotes emerged within a much more complex microbial ecosystem? A fascinating study from
@tonigabaldon.bsky.social
et al. explores exactly this. 🧵
add a skeleton here at some point
1
21
9
reposted by
Toni Gabaldón
Patricia Ruiz Guevara
17 days ago
¿De dónde venimos? El gran salto evolutivo del que surgieron las células complejas que nos conforman es un enigma. Un estudio de
@irbbarcelona.org
y
@bsc-cns.bsky.social
revela que hay más actores implicados de los que pensábamos El 'ménage à trois' celular 👉
www.elconfidencial.com/tecnologia/c...
1
7
8
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis.
doi.org/10.1038/s415...
17 days ago
10
263
135
reposted by
Toni Gabaldón
Adam Rutherford
18 days ago
Doing a PhD is not simply generating data. It’s learning how to be a scientist. It’s teaching and science communication, and writing, and presenting and FUCKING THINKING.
8
288
39
reposted by
Toni Gabaldón
Robin Z
23 days ago
Possibly the best way to phish academics would be to just send them email that looks like a request to review an article and embed your malware in the "decline to review" link
9
248
44
I’ll be participating this year. Discussing the wonders of DNA sequencing over a “scientific coffee” with interested citizens. Come and join us!
add a skeleton here at some point
about 1 month ago
1
7
2
De camino a Bilbao donde partiparé en
#SEIMC2026
con una ponencia sobre virulencia, resistencia, y adaptación en hongos patógenos.
www.seimc2026.org
about 1 month ago
0
3
1
reposted by
Toni Gabaldón
Javier Santoyo
7 months ago
MeTAline: enabling reproducible and scalable metagenomic analyses.
#MetagenomicAnalysis
#ShotgunMetagenomics
#Snakemake
#Containers
#HPC
#Bioinformatics
#Genomics
#NARgenomicsAndBioinformatics
🧪🧬 🖥️
academic.oup.com/nargab/artic...
0
4
2
reposted by
Toni Gabaldón
IRB Barcelona
about 1 month ago
✨ Join us at
#IRBBarcelona
Open Day! 📅 Saturday, May 30 A day of science, discovery, and hands-on activities for all ages. 🎟️ Sign up and don’t miss it! 👉 https://bit.ly/4ddD7VA
#ExperimentaIRB
loading . . .
Vine a la Jornada de Portes Obertes de l'IRB Barcelona!
L’any passat va ser brutal... 😍🔬 Vam descobrir plegats com la ciè...
https://youtu.be/TnDI1DIHStg
0
6
5
reposted by
Toni Gabaldón
Comparative genomics group IRB-BSC Barcelona (PI: Toni Gabaldón)
about 1 month ago
Once more our group was present in the nice FEBS advanced course
#hfp2026
at La Colle. With presentations and posters by
@tonigabaldon.bsky.social
Mrina, and Vlad. As always the conference was great! Thank you to the organizers!
0
6
1
reposted by
Toni Gabaldón
Saioa Manzano-Morales
about 1 month ago
Interested in Asgard archaea?
@tonigabaldon.bsky.social
and I wrote a small blog post on our most recent paper about these fascinating group of prokaryotes and their genome dynamics:
go.nature.com/4uPLY5W
loading . . .
How the closest relatives of eukaryotes grew a larger genome
Asgard archaea have emerged as key organisms to understand eukaryogenesis. Among their many fascinating features is their atypically large genomes. Here, we dive deep into Asgard genome evolution to u...
https://go.nature.com/4uPLY5W
0
34
10
reposted by
Toni Gabaldón
Comparative genomics group IRB-BSC Barcelona (PI: Toni Gabaldón)
about 1 month ago
#post
Read our "behind the paper" blog post on our latest publication on
#Asgard
phylogenomics to get a starter on the significance of our findings. by
@microbiobits.bsky.social
and
@tonigabaldon.bsky.social
Enjoy 👇
communities.springernature.com/posts/how-th...
0
3
2
Was a pleasure to participate as an invited speaker at the 7th retreat of the Biology Dept of university of Padova!. This have me the chance to visit the oldest preserved botanical garden.
about 1 month ago
1
6
1
reposted by
Toni Gabaldón
Comparative genomics group IRB-BSC Barcelona (PI: Toni Gabaldón)
about 2 months ago
#paper
Echinocandin-resistant Nakaseomyces glabratus can retain fitness across host niches. This could help explain breakthrough infections. FKS requirements are niche-specific: FKS1/FKS2 support gut colonization, while FKS2 is key for systemic infection.
journals.asm.org/doi/10.1128/...
loading . . .
Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during in...
The increasing rate of drug-resistant microbes stands as one of the major public health threats facing modern medicine (1). The severity of the emerging threat of drug resistance is more profound for ...
https://journals.asm.org/doi/10.1128/aac.01801-25?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
0
2
1
reposted by
Toni Gabaldón
Comparative genomics group IRB-BSC Barcelona (PI: Toni Gabaldón)
2 months ago
#ESCMIDGlobal2026
is over. The group participated with oral presentations from Hrant Hovhannisyan (computational multiplexing optimization) and
@tonigabaldon.bsky.social
(evolutionary genomics of
#Candida
), there was a lot of learning and networking.
0
3
2
reposted by
Toni Gabaldón
EvolDir
2 months ago
📣 EvolDir is now managed by
@eseb.bsky.social
! We are delighted to be taking the reins and express our gratitude to both Brian Golding who began this service to the community in the mid-1980s and to
@rdmpage.bsky.social
who ran this account until now 👏 You can now find evoldir here:
evoldir.net
2
176
92
reposted by
Toni Gabaldón
Yassen Tcholakov
2 months ago
This is the cool stuff: phage steering - using phages to force evolutionary trade-offs in pathogen! Sounds a bit Science-fictiony but there's now clinical studies on small groups of patients!
#ESCMIDGlobal2026
1
6
1
reposted by
Toni Gabaldón
Krutika Kuppalli, MD FIDSA
2 months ago
“The Year in Clinical Micro” at
#ESCMIDGlobal2026
🔬 Take-home message: Culture-free diagnostics + AI are transforming ID & AST —faster, increasingly accurate, and moving us toward earlier targeted therapy and smarter antibiotic use. Not quite perfect yet—but clearly the future
1
5
1
reposted by
Toni Gabaldón
Ismael Mingarro
2 months ago
Demà 📅 20 d'abril presentem a la📍SalaDarwin el documental 🎦
#UnSafariAlPleistoceno
dirigit per
#AlejandroArtés
i assessorat per l'investigador
#PedroPiñero
@biologiques-uv.bsky.social
director del jaciment Quibas (Abanilla, Múrcia), q recrea la serra fa 1 milió d'anys
www.uv.es/uvweb/biolog...
loading . . .
Projecció del curtmetratge ‘Un safari al Pleistoceno’’, un viatge al sud-est peninsular de fa un milió d'anys
El pròxim 20 d'abril de 2026 a les 18.00 hores a la Sala Charles Darwin del Campus de Burjassot Paterna es projectarà el documental ‘Un safari al Pleistoceno’, un curtmetratge pioner que recrea el pai...
https://www.uv.es/uvweb/biologicas/ca/novetats/projeccio-curtmetratge-safari-pleistoceno-viatge-sud-est-peninsular-fa-milio-anys-1285923198745/Novetat.html?id=1286480653888
1
7
3
Will be at
#ESCMIDGlobal2026
for the next days. Looking forward to meet colleagues and present our work on
#Candida
add a skeleton here at some point
2 months ago
0
2
1
reposted by
Toni Gabaldón
Cameron Thrash
3 months ago
Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication
www.nature.com/articles/s41...
#jcampubs
loading . . .
Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication - Nature Communications
The genomes of Asgard archaea, the closest prokaryotic relatives to eukaryotes, are larger than those of other archaea and contain multiple genes seemingly acquired from bacteria. Here, Manzano-Morales and Gabaldón quantify gene duplication, loss, and transfer events in Asgard genomes, showing that gene duplications, rather than horizontal gene transfers, are the primary drivers behind the increased genome sizes.
https://www.nature.com/articles/s41467-026-71534-5
0
12
5
reposted by
Toni Gabaldón
Zorro guardapavos
3 months ago
'Asgard archaea' no solo sigue siendo un nombre chulo, además están mostrando más y más maneras en las que parecen una forma transicional entre procariotas y eucariotas
add a skeleton here at some point
1
3
2
reposted by
Toni Gabaldón
IRB Barcelona
3 months ago
🔬 New #FAQ drops key insights on Barcelona's #AfricanSwineFever outbreak from
@gabaldonlab.bsky.social
: They've sequenced the outbreak strain's genome and compared it with known variants to trace origins and characteristics. ➡️ https://shorturl.at/P02ME #ASF
@tonigabaldon.bsky.social
1
4
3
reposted by
Toni Gabaldón
Molecular Systems Biology
3 months ago
fitness costs are associated with acquired antifungal resistance in N. glabratus, and these trade-offs can be targeted by drugs as shown by
@gabaldonlab.bsky.social
➡️
link.springer.com/article/10.1...
0
5
5
reposted by
Toni Gabaldón
Comparative genomics group IRB-BSC Barcelona (PI: Toni Gabaldón)
3 months ago
#Paper
Our new study on
#Asgard
archaea is out in Nature Communications. We find a distinctive evolutionary pattern: widespread
#HGT
, but genome expansion mainly through gene duplication. An interesting window into the origins of
#eukaryotic
complexity.
www.nature.com/articles/s41...
loading . . .
Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication - Nature Communications
The genomes of Asgard archaea, the closest prokaryotic relatives to eukaryotes, are larger than those of other archaea and contain multiple genes seemingly acquired from bacteria. Here, Manzano-Morale...
https://www.nature.com/articles/s41467-026-71534-5
0
19
9
We put together this FAQ on the African swine fever outbreak in Barcelona, based on current evidence. My group helped sequence the outbreak strain and compare it with other
#ASFV
virus genomes to explore its origins and features.
#AfricanSwineFever
www.pig333.com/articles/fre...
loading . . .
Frequently asked questions about the ASF virus detected in Barcelona
The virus detected in Barcelona is ASF genotype II and has been classified in a new genetic group: #29.
https://www.pig333.com/articles/frequently-asked-questions-about-the-asf-virus-detected-in-barcelona_22333/
3 months ago
0
6
1
reposted by
Toni Gabaldón
Friday 6th March at 12:00 I'll be speaking at the
@irbbarcelona.org
seminar series. "Deadly yeasts: unexpected origins and foreseeable future" 👇
www.irbbarcelona.org/en/events/de...
4 months ago
0
8
2
Friday 6th March at 12:00 I'll be speaking at the
@irbbarcelona.org
seminar series. "Deadly yeasts: unexpected origins and foreseeable future" 👇
www.irbbarcelona.org/en/events/de...
4 months ago
0
8
2
As part of
@bsc-cns.bsky.social
participation at the
#MWC26
and
#4YN
I will be presenting our applications of using hashtag#IA for the early diagnosis of colorectal cancer from fecal microbiome profiles (#MiCRC) Come and meet me on the 4th March at our booth
x4hpc.cat/mwc26/agenda...
loading . . .
Agenda - BSC MWC 2026 Agenda
Explore BSC's agenda for 4YFN 2026, featuring key events and presentations on cutting-edge technology and innovations. Discover what’s next at the Mobile World Congress.
https://x4hpc.cat/mwc26/agenda/?agenda=2
4 months ago
0
3
1
Load more
feeds!
log in