FAK Inhibition Remodels the Metastatic ECM and Restores CD8+ T Cell Trafficking and Immunosurveillance https://www.biorxiv.org/content/10.64898/2026.01.21.700837v1

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs). Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬 Details in thread 🧵👇 #ScienceSky #Postdoc #AcademicJobs Please RT🫶

Mark your calendars, the Signaling by Adhesion Receptors GRC is June 7 - 12, 2026. We have a terrific program that balances developmental biology, cell polarity, and adhesion and signaling. Please spread the word! www.grc.org/signaling-by...

📱Is the origin of animals comparable to the origin of the smartphones? Yes! See our new review in @embojournal.org where we show how important it was the new "Operating System" (animalOS)for animals to evolve! with @ricardsole.bsky.social, Nick and Elena @ibe-barcelona.bsky.social @csic.es @prbb.org

Excited to share our new preprint! and the surprising finding that the second integrin-binding site (IBS2) does not bind integrin. IBS2 can be better explained as talin-talin interactions mediated via a cryptic talin-binding site in R11. We also show a new role for vinculin as a mechano-chaperone

KANK2 plays a dual role – dictating cells when to move and when to stick! @vibhasingh.bsky.social covers recent work from Nikolina Stojanović & colleagues – includes a lovely discussion with the author team. #preLight ⬇️ prelights.biologists.com/highlights/k...

Looking for an easy-to-use yet physiologically relevant system to study cancer cell invasion? In our new preprint we use decellularized mouse tissues to model organ-specific invasion, preserving native ECM properties and recapitulating metastatic organotropism! www.biorxiv.org/content/10.6...

🧪Our special issue "𝐂𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐚𝐧𝐝 𝐌𝐨𝐥𝐞𝐜𝐮𝐥𝐚𝐫 𝐀𝐬𝐩𝐞𝐜𝐭𝐬 𝐨𝐟 𝐌𝐞𝐜𝐡𝐚𝐧𝐨𝐛𝐢𝐨𝐥𝐨𝐠𝐲 𝐨𝐟 𝐭𝐡𝐞 𝐄𝐱𝐭𝐫𝐚𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐌𝐚𝐭𝐫𝐢𝐱" (Curr Opin Biomed Eng, Vol.37 Mar 2026) is out 🎉 🔬Thanks to all authors, may this spark cross‑disciplinary collaboration! www.sciencedirect.com/science/arti... #Mechanobiology #ECMatrix #Biomaterials

FlowVision: @guijacquemet.bsky.social @johannaivaska.bsky.social et al describe a fast label-free live imaging approach revealing key principles of cancer cell arrest on endothelial monolayers–such as flow dynamics & CD44 interaction with matrix hyaluronic acid link.springer.com/article/10.1...

Roza Masalmeh, @margaretframe.bsky.social & co uncover a FAK–ROCK-driven mechanism that links #ExtracellularMatrix mechanical cues to the rewiring of energy #metabolism, affecting mitochondrial function and malignant behaviour. #mitochondria #cancer Read doi.org/10.1242/dmm....

Talin didn’t evolve for integrins... integrins evolved for talin 🤯 pN force coupling via talin is ancient, conserved from amoebae to humans; signaling came later. Read this amazing paper here 👇🏽 www.nature.com/articles/s41...

We are very happy to share our latest work exploring the role of newly synthetized integrin-α5 using RUSH. We found that a subset goes to the PM via unconventional secretion! Big thanks to all involved! Read more at doi.org/10.1083/jcb.... @mathildemathieu.bsky.social @martina-lerche.bsky.social

Xingchen Li, Christoph Ballestrem, et al. @mcrcellmatrix.bsky.social show that multidomain interactions between talin and tensin3 regulate #integrin activity, fibrillar #adhesion formation, #fibronectin assembly, and mechanosensitive tensin3 phase separation. rupress.org/jcb/article/...

We finally made it over here ! And excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! www.cell.com/cell-reports...

Congratulations to Drs. Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, recipients of the 2025 Nobel Prize in Physiology or Medicine. Brunkow and Ramsdell—cell biologists by training—prove once again: it’s all about the cell.

Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social

Our paper is on the cover of @cp-devcell.bsky.social . Image: embryonic murine salivary-gland explants stained for fate determinants; p63 (cyan) and HES1 (yellow). Thanks to everyone involved. doi.org/10.1016/j.de...

Interested in doing exciting research on #epithelial #plasticity in the #kidney or #intestine? Then please check out our recent job ads for #PhD and #Postdoc positions! www.nature.com/naturecareer... www.nature.com/naturecareer... www.nature.com/naturecareer... www.nature.com/naturecareer...

Mathematical models are essential tools for exploring the complex interplay between #cancer cells and their environment, but require expertise and abundant data to develop. Lance Munn & Rakesh Jain suggest that #AI is leading the way towards the next wave of tumor models 🧪 plos.io/4ofREUk

New in @jcellsci.bsky.social, Cancer Center member Alexandra Naba, PhD co-develops MatriCom, a web app + R package to decode cell–ECM communication from single-cell RNA-Seq data. Funded by the NIH and the NCI. #CancerResearch #CanSky Read more here: bit.ly/4m9aUS3

Happy to share our work on the role of biomechanical PULSATILITY on lung vessels. Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️‍🩹 www.biorxiv.org/content/10.1...

Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes https://go.nature.com/3Z6mJ1X

The cellular dance that splits vessels Really appreciate this insightful commentary by Dr. Lance Munn on our recent paper @pnas.org using Microvessel-On-A-Chip to model the pillariogenesis during early #IntussusceptiveAngiogenesis 😎 pnas.org/doi/abs/10.1073/pnas.2508260122

EpiSci - Hi there! Our review “Mechanotransduction in stem cells” is finally published. With @carstenschulte4.bsky.social we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/

1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist. cshperspectives.cshlp.org/content/earl...

Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules! We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!

Xiao, G. et al. (2025). Intratumor HIF-1a modulates production of a cachectic ligand to cause host wasting. Cell Insight. doi: 10.1016/j.cellin.2025.100247. PMID: 40336592

Improved Tumor Blood Flow Enhances the Abscopal Effect: Preclinical Assessment in Mice Treated with Combined Radiation and PD-1 Blockade Therapy https://www.biorxiv.org/content/10.1101/2025.05.04.652150v1

new out in Nature www.nature.com/articles/s41...

📣 Publication in @nature.com A new class of molecules capable of killing #cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed by scientists at Institut Curie, @cnrs.fr and @inserm.fr Read publication 👉 www.nature.com/articles/s41...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution We are excited to present our latest work published in @natcomms.nature.com www.nature.com/articles/s41...

Representing the TME working group, @megeblad.bsky.social just presented a mesmerizing talk about the role of #neutrophils and their DNA traps inside vessels at the necrotic and peri necrotic niches and their role in metastasis A true eye opener!!! #AACR25 @theaacr.bsky.social

Ludwig @harvard.edu’s Rakesh Jain, recipient of the #AACR2025 Award for Lifetime Achievement in Cancer Research, told the tale of his 4-decade journey from proposing the vascular normalization hypothesis to seeing it applied today to treat multiple cancers. bit.ly/3Egq1bv

KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi @ipparis.bsky.social @polytechniqueparis.bsky.social

Also in Issue 7: - Research Highlights on ATG9A INVs, airway epithelia & Formin 3 - JCS–David Stephens Prize - Emmanuel Derivery @deriverylab.bsky.social Interview - Regulation of cell migration by ECM mechanics - Data exploration in quantitative #cellbio journals.biologists.com/jcs/issue/13...

Just published!🎉 Excited to present Pickering lab's work on @pnas.org #IntussusceptiveAngiogenesis-On-A-Chip🤩 For 1st time in vitro, we rebuilt multicellular pillars composed of #EndothelialCells crossing a pressurized, flowing channel🤓 Kudos to our stellar Sabrina🌟 www.pnas.org/doi/10.1073/...

Functions & application of circRNAs in #VascularAging & aging-related vascular diseases miR sponge Linear mRNA translation Interact with epigenetic/transcriptional machinery Form R-loop on host gene Protein-coding #JNanobiotech 2025 jnanobiotechnology.biomedcentral.com/articles/10....

#REVIEW 🚨 Fibroinflammation contributes to tumour initiation, growth and metastasis. Zebin Xiao & Ellen Puré outline the complexity of cancer-associated fibroinflammation and provide insights on therapeutically targeting this. @upenn.edu#REVIEW 👀 ⬇️

A #collagen IV fluorophore knock-in toolkit reveals trimer diversity in #Celegans basement membranes. A new toolkit from Sandhya Srinivasan, David Sherwood and colleagues @duke-university.bsky.social: rupress.org/jcb/article/... #Development #Adhesion #Disease #Migration #motility

In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

Fibrosis: cross-organ biology and pathways to development of innovative drugs www.nature.com/articles/s41... rdcu.be/eejqi This new Review highlights core pathways active in fibrotic conditions across organs, and proposes strategies to improve the translation of potential antifibrotic drugs

Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪 plos.io/3DRtAEW

Researchers led by Ludwig @fbm-unil.bsky.social’s @lbejarano.bsky.social & @johannajoyce.bsky.social analyzed individual cells of the blood-brain barrier across brain tissue, primary brain tumors & brain metastases, creating a vascular atlas to guide the design of new therapies. bit.ly/4bFqwYY

"The end of the genetic paradigm of cancer" - a provocative piece in @plosbiology.org from Sui Huang, Ana Soto & Carlos Sonnenschein: "We expect that the diminishing returns from the ceaselessly growing databases of somatic mutations... may soon reach a pivot point" journals.plos.org/plosbiology/...

Interesting. Includes two leukocyte integrin subunits.

Proteins that allow water to move in and out of cells help shape the development of new blood vessels. buff.ly/Sl19tgH

Congratulations to Ludwig @unil.bsky.social’s Douglas Hanahan on being honored with the 2025 Pezcoller [email protected] International Award for Extraordinary Achievement in Cancer Research for his seminal contributions to the field. Learn more here: bit.ly/3DGCnt6 #CanSky #OncoSky

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...